Regulation of tumor invasion and metastasis by matrix remodeling on the cell surface

• Project/Area Number: 19770108
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional biochemistry
• Research Institution: Osaka University
• Principal Investigator: MURAI Toshiyuki Osaka University, 医学系研究科, 助教 (20311756)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 酵素 / 癌 / 糖鎖

Research Abstract

癌細胞の細胞膜近傍領域で起こる細胞外マトリックスのリモデリングを、経時的に測定するための方法を確立した。本研究の成果を応用することにより、癌の浸潤・転移を制御する機構の解明のための道を拓くことに貢献できる。

Research Products

• [Journal Article] A simple assay for hyaluronidase activity using fluorescence polarization. (2008)
  • Author(s): Toshiyuki Murai and Hiroto Kawashima.
  • Journal Title: Biochemical and Biophysical Research Communications Vol.376 Pages: 620-624
  • Peer Reviewed
• [Journal Article] A simple assay for hyaluronidase activity using fluorescence polarization (2008)
  • Author(s): Murai, T., et.al.
  • Journal Title: Biochem. Biophys. Res. Commun 376 Pages: 620-624
  • Peer Reviewed
• [Presentation] Tools for analysis of cell adhesion molecules under physiological and pathological conditions. (2008)
  • Author(s): Toshiyuki Murai and Hiroto Kawashima.
  • Organizer: International Symposium on Micro-Nano Mechatronics and Human Science.
  • Place of Presentation: 名古屋大学
  • Year and Date: 2008-11-08
• [Presentation] Tools for analysis of cell adhesion molecules under physiological and pathological conditions (2008)
  • Author(s): Murai, T. et.al.
  • Organizer: International Symposium on Micro-Nano Mechatronics and Human Science
  • Place of Presentation: 名古屋大学
  • Year and Date: 2008-11-08