Molecular analysis of CaM kinase cascade in vertebrate embryogenesis
Project/Area Number |
19770110
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Functional biochemistry
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Research Institution | Kagawa University |
Principal Investigator |
SUEYOSHI Noriyuki Kagawa University, 農学部, 准教授 (90346635)
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Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,300,000 (Direct Cost: ¥2,300,000)
|
Keywords | CaMKP / CaMKP-N / apoptosis / zebrafish / CaM kinase |
Research Abstract |
多機能性CaMキナーゼを脱リン酸化して負に制御するCaMKPとCaMKP-Nをなくしたゼブラフィッシュ胚では、両酵素の発現部位と一致してアポトーシス(細胞の自殺)が観察された。このことは、脊椎動物の胚発生において、CaMキナーゼによるシグナル伝達経路が重要な役割を持つことを示す。CaMKPは基質であるCaMキナーゼによってリン酸化され、活性化された。一方でCaMKP-NはプロテアーゼによってC末を分解されることによって活性化された。
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Report
(3 results)
Research Products
(79 results)
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[Journal Article] Novel Ca2+/calmodulin-dependent protein kinase expressed in actively growing mycelia of the basidiomycetous mushroom Coprinus cinereus.2009
Author(s)
Kaneko, K., Yamada, Y., Sueyoshi, N., Watanabe, A., Asada, Y., Kameshita, I.
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Journal Title
Biochim. Biophys. Acta. 1790
Pages: 71-79
Related Report
Peer Reviewed
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[Journal Article] Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase.2009
Author(s)
Inoue, T., Okino, N., Kakuta, Y., Hijikata, A., Okano, H., Goda, H.M., Tani, M., Sueyoshi, N., Kambayashi, K., Matsumura, H., Kai, Y., Ito, M.
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Journal Title
J. Biol. Chem. 284
Pages: 9566-9577
Related Report
Peer Reviewed
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[Journal Article] Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase2009
Author(s)
Inoue, T., Okino ; N., Kakuta, Y., Hijikata, A., Okano, H., Goda, H.M. ; Tani, M., Sueyoshi, N., Kambayashi, K., Matsumura, H., Kai, Y, Ito, M.
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Journal Title
J. Biol. Chem 284
Pages: 9566-9577
Related Report
Peer Reviewed
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[Journal Article] Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1.2008
Author(s)
Kameshita, I., Sekiguchi, M., Hamasaki, D., Sugiyama, Y., Hatano, N., Suetake, I., Tajima, S., Sueyoshi, N.
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Journal Title
Biochem. Biophys. Res. Commun. 377
Pages: 1162-1167
Related Report
Peer Reviewed
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[Journal Article] Activation of SAD kinase by Ca2+/calmodulin-dependent protein kinase kinase.2008
Author(s)
Fujimoto, T., Yurimoto, S., Hatano, N., Nozaki, N., Sueyoshi, N., Kameshita, I., Mizutani, A., Mikoshiba, K., Kobayashi, R., Tokumitsu, H.
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Journal Title
Biochemistry 47
Pages: 4151-4159
Related Report
Peer Reviewed
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[Journal Article] Cyclindependent kinase-like 5 binds and phosphorylates DNA methyltransferase 12008
Author(s)
Kameshita, I., Sekiguchi, M., Hamasaki, D., Sugiyama, Y, Hatano, N., Suetake, I., Tajima, S., Sueyoshi, N.
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Journal Title
Biochem. Biophys. Res. Commun 377
Pages: 1162-1167
Related Report
Peer Reviewed
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[Journal Article] Activation of SAD kinase by Ca2+/calmodulindependent protein kinase kinase2008
Author(s)
Fujimoto, T., Yurimoto, S., Hatano, N., Nozaki, N., Sueyoshi, N., Kameshita, I., Mizutani, A., Mikoshiba, K., Kobayashi. R.. Tokumitsu, H.
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Journal Title
Biochemistry 47
Pages: 4151-4159
Related Report
Peer Reviewed
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[Journal Article] Knockdown of nuclear Ca2+/calmodulin-dependent protein kinase phosphatase causes developmental abnormalities in zebrafish2007
Author(s)
Nimura, T., Sueyoshi, N., Ishida, A., Yoshimura, Y., Ito, M., Tokumitsu, H., Shigeri, Y., Nozaki, N., and Kameshita, I.
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Journal Title
Arch. Biochem. Biophys 457
Pages: 205-216
Related Report
Peer Reviewed
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[Journal Article] Inhibitors of the Ca2+/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N)2007
Author(s)
Sueyoshi, N., Takao, T., Nimura, T., Sugiyama, Y., Numano, T., Shigeri, Y., Taniguchi, T., Kameshita, I., Ishida, A.
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Journal Title
Biochem. Biophys. Res. Commun 363
Pages: 715-721
Related Report
Peer Reviewed
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[Journal Article] Involvement of Ca2+/calmodulin-dependent protein kinases in mycelial growth of the basidiomycetous mushroom, Coprinus cinereus2007
Author(s)
Kameshita, I., Yamada, Y., Nishida, T., Sugiyama, Y., Sueyoshi, N., Watanabe, A., Asada, Y.
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Journal Title
Biochim. Biophys. Acta 1770
Pages: 1395-1403
Related Report
Peer Reviewed
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[Journal Article] Expression, characterization, and gene knockdown of zebrafish doublecortin-like protein kinase2007
Author(s)
Shimomura, S., Nagamine, T., Nimura, T., Sueyoshi, N., Shigeri, Y., Kameshita, I.
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Journal Title
Arch. Biochem. Biophys 463
Pages: 218-230
Related Report
Peer Reviewed
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[Journal Article] Involvement of Ca^<2+>/calmodulin-dependent protein kinases in mycelialgrowth of the basidiomycetous mushroom, Coprinus cinereus.2007
Author(s)
Kameshita, I., Yamada, Y., Nishida, T., Sugiyama, Y., Sueyoshi, N.他
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Journal Title
Biochim. Biophys. Acta. 1770
Pages: 1395-1403
Related Report
Peer Reviewed
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[Presentation] Catalytic properties of zebrafish boublecortin-like protein kinase (zDCLK).2008
Author(s)
Shimomura, S., Nagamine, T., Nimura, T., Sueyoshi, N., Kameshita, I.
Organizer
11th IUBMB Conference
Place of Presentation
Athens,Greece
Year and Date
2008-07-01
Related Report
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[Presentation] Calmodulin-dependent protein kinase IV regulates insulin secretion under the glucotoxic condition in INS-1 rat insulinoma cell line.2008
Author(s)
Sugiyama, Y., Murao, K., Imachi, H., Sueyoshi, N., Ishida, I., Kameshita, I.
Organizer
11th IUBMB Conference
Place of Presentation
Athens,Greece
Year and Date
2008-07-01
Related Report
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[Presentation] Calmoduliri-dependent protein kinase IV regulates insulin secretion under the glucotoxic condition in INS-1 rat insulinoma cell line2008
Author(s)
Sugiyama, Y, Murao, K., Imachi, H., Sueyoshi, N., Ishida, I., Kameshita, I.
Organizer
11th IUBMB Conference
Place of Presentation
ギリシャ アテネ
Year and Date
2008-07-01
Related Report
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[Presentation] 緑膿菌由来の中性セラミダーゼのX線結晶構造解析と反応機構の解明2008
Author(s)
沖野望,井上豪,角田佳充,土方敦司,岡野浩幸,上林浩二,合田(問註所)初美,谷元洋,末吉紀行,松村浩由,甲斐泰,伊東信
Organizer
第31回日本分子生物学会年会第81回日本生化学会大会合同大会
Place of Presentation
神戸
Related Report
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