Analysis of complement activation in MASP-deficient mice
Project/Area Number |
19770113
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Functional biochemistry
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Research Institution | Fukushima Medical University |
Principal Investigator |
IWAKI Daisuke Fukushima Medical University, 医学部, 助教 (10315492)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥3,930,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
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Keywords | 自然免疫 / 補体 / レクチン / セリンプロテアーゼ |
Research Abstract |
MASP-1 and MASP-2 are known to cleave some complement components and contribute to activation of the complement system. On the other hand, the function of MASP-3 remains unclear. To further clarify the roles of MASPs we generated and analyzed 3 types of MASP-deficient mice. In this study, we found a way to activate MASP-3 and the protease might be involved in activation of the alternative complement pathway.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway.2008
Author(s)
M. Takahashi, D. Iwaki, K. Kanno, Y. Ishida, J. Xiong, M. Matsushita, Y. Endo, S. Miura, N. Ishii, K. Sugamura, T. Fujita
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Journal Title
J. Immunol. 180
Pages: 6132-6138
Related Report
Peer Reviewed
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