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Elucidation of molecular mechanisms of a multifunctional cytokine GBP in host defense

Research Project

Project/Area Number 19770123
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionHokkaido University

Principal Investigator

AIZAWA Tomoyasu  Hokkaido University, 大学院・先端生命科学研究院, 准教授 (40333596)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords構造生物学 / 生体防御 / サイトカイン / ペプチド / NMR / 立体構造
Research Abstract

チョウやガの仲間である鱗翅目昆虫、アワヨトウから発見された多機能サイトカインGBP は、血球の活性化などの生体防御や幼虫の成長に関連して重要な役割を担っていると推定されるが、その分子レベルでの作用機構については未知の点が多く残されている。GBP の各種変異体を調整し、その立体構造と活性の関係について検討を行うことで、昆虫の寄生に伴う成長抑制や、創傷や感染と関連した血球の働き等に関して興味深い成果を得ることに成功した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (6 results)

  • [Journal Article] A Novel Peptide Mediates Aggregation and Migration of Hemocytes From an Insect2009

    • Author(s)
      Nakatogawa S
    • Journal Title

      Current biology (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Structure of a Novel Insect Peptide Explains Its Ca(2+) Channel Blocking and Antifungal Activities2008

    • Author(s)
      Kouno T
    • Journal Title

      Biochemistry (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The structure of a novel insect peptide explains its Ca2+ channel blocking and antifungal activities2007

    • Author(s)
      T. Kouno, M. Mizuguchi, H. Tanaka, P. Yang, Y. Mori, H. Shinoda, K. Unoki, T. Aizawa, M. Demura, K. Suzuki, and K. Kawano
    • Journal Title

      Biochemistry 46

      Pages: 13733-13741

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif2007

    • Author(s)
      N. Fujitani, T. Kouno, T. Nakahara, K. Takaya, T. Osaki, S. Kawabata, M. Mizuguchi, T. Aizawa, M. Demura, S. Nishimura, and K. Kawano
    • Journal Title

      J. Pept. Sci 13

      Pages: 269-279

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural approach to a novel tandem repeat DNA-binding domain, STPR, by CD and NMR2007

    • Author(s)
      S. Saito, T. Aizawa, K. Kawaguchi, T. Yamaki, D. Matsumoto, M. Kamiya, Y. Kumaki, M. Mizuguchi, S. Takiya, M. Demura, and K. Kawano
    • Journal Title

      Biochemistry 46

      Pages: 1703-1713

    • Related Report
      2008 Final Research Report
  • [Journal Article] The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif2007

    • Author(s)
      Fujitani N
    • Journal Title

      J. Pept. Sci. 13

      Pages: 269-279

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Approach to a Novel Tandem Repeat DNA-Binding Domain, STPR, by CD and NMR2007

    • Author(s)
      S. Saito
    • Journal Title

      Biochemistry 46

      Pages: 1703-1713

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel peptide mediates aggregation and migration of hemocytes from an insect

    • Author(s)
      S. Nakatogawa, Y. Oda, M. Kamiya, T. Kamijima, T. Aizawa, K. D. Clark, M. Demura, K. Kawano, M. R. Strand and Y. Hayakawa
    • Journal Title

      Curr. Biol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 昆虫由来成長阻害因子Growth-blocking peptide(GBP)の寄生によるC 末端残基伸長が生体膜相互作用と活性に与える影響2008

    • Author(s)
      梅津喜崇,相沢智康,武藤香織,山本宏子, 神谷昌克,熊木康裕,水口峰之,出村誠,早川洋一,河野敬一
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Final Research Report
  • [Presentation] 昆虫由来成長阻害因子Growth-blocking peptide(GBP)の寄生によるC末端伸長が生体膜相互作用と活性に与える影響2008

    • Author(s)
      梅津喜崇
    • Organizer
      第31回目本分子生物学会年会・第81回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] 成長阻害因子GBPのC 末端残基伸長が構造と活性に与える影響2007

    • Author(s)
      梅津喜崇,相沢智康,武藤香織,山本宏子, 神谷昌克,熊木康裕,水口峰之,出村誠,早川洋一,河野敬一
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山国際会議場
    • Related Report
      2008 Final Research Report
  • [Presentation] 成長阻害因子growth-blocking peptide(GBP)のC末端残基伸長部分による生体膜相互作用が立体構造と活性に与える影響2007

    • Author(s)
      梅津喜崇,相沢智康,武藤香織,山本宏子, 神谷昌克,熊木康裕,水口峰之,出村誠,早川洋一, 河野敬一
    • Organizer
      第7回日本蛋白質科学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2008 Final Research Report
  • [Presentation] 成長阻害因子growth-blocking peptide (GBP)のC末端残基伸長部分による生体膜相互作用が立体構造と活性に与える影響2007

    • Author(s)
      梅津 喜崇
    • Organizer
      第7回日本蛋白質科学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2007 Annual Research Report
  • [Presentation] 成長阻害因子GBPのC末端残基伸長が構造と活性に与える影響2007

    • Author(s)
      梅津 喜崇
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山国際会議場
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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