Studies on relationships between structure and function of RNA aptamer and non-coding RNA that related to diseases.
| Project/Area Number |
19770133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Yokohama City University |
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Principal Investigator |
OHYAMA Takako Yokohama City University, 国際総合科学研究科, 客員研究員 (70433191)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | 多剤耐性 / non-cording RNA / NMR / Vault RNA / 抗がん剤 |
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| Research Abstract |
C型肝炎ウィルスの遺伝子の翻訳を特異的に阻害するRNAアプタマー、多剤耐性株の出現に関連するノンコーディングRNA、の2つの機能性RNAの立体構造と機能の相関をNMRにより解析した。多剤耐性株の出現に関連するノンコーディングRNAについては、薬剤との結合を検出し、その結合は連続した芳香環またはシクロヘキサン化学構造を認識していることを明らかとした。
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Structural analysis of Musashi-RNA complex on the basis of long-range structural information2008
Author(s)
Ohyama, T., Furukawa, A., Mashima, T., Sugiyama, T., Ohgara, S., Yamazaki, T., Imai, T., Okano, H., Nagata, T. and Katahira, M.
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Journal Title
Nucleic Acids Symp. Ser. No. 52
Pages: 193-194
Related Report
Peer Reviewed
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[Journal Article] Interactions with RNA/DNA of proteins involved in the regulation of transcription, translation and telomere elongation.2007
Author(s)
Ohyama T, Furukawa A, Miyoshi T, Takada Y, Ohgara S, Hiratsuka K, Imai T, Okano H, Nakagama H, Nagata T, Katahira M.
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Journal Title
Nucleic Acids Symp Ser (Oxf). (51)
Pages: 77-78
Related Report
Peer Reviewed
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