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Protein complex analysis for the Chromatin regulation and its functional network

Research Project

Project/Area Number 19770152
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Molecular biology
Research InstitutionNagoya City University

Principal Investigator

TAGAMI Hideaki  Nagoya City University, 大学院・システム自然科学研究科, 准教授 (70273216)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,790,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsヒストン / タンパク質複合体 / クロマチン制御 / 機能ネットワーク / ヒストン複合体
Research Abstract

本研究ではヒストン複合体解析を通してクロマチン形成の分子機構、および動的なクロマチン制御を介する細胞機能の解明を目指した。酵母をモデル系として、様々な条件下におけるヒストン複合体を精製し、ヒストン相互作用因子ネットワークとそのダイナミクス解析を行った。酵母やヒトのヒストン複合体を比較することでクロマチン形成の共通の分子基盤と戦略のバリエーションが示唆された。また、ヒストンシャペロンFACTが複製や転写だけでなく、よりグローバルにヒストンH2A/H2Bをクロマチンから解離させるという興味深い結果を得た。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results) Book (1 results)

  • [Journal Article] The HP1α-CAF-1-SetDB1 complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin2009

    • Author(s)
      Alejandra Loyola, Hideaki Tagami, Tiziana Bonaldi, Daniele Roche, Jean Pierre Quivy, Axel Imhof, Yoshihiro Nakatani, Sharon YR Dent, and Genevieve Almouzni
    • Journal Title

      EMBO Reports (accepted)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] HJURP, a key CENP-A-partner for maintenance and deposition of CENP-A at centromeres at late telophase/G12009

    • Author(s)
      Elaine M. Dunleavy, Daniele Roche, Hideaki Tagami, Nicolas Lacoste, Dominique Ray-Gallet, Yusuke Nakamura, Yataro Daigo, Yoshihiro Nakatani, Genevieve Almouzni-Pettinotti.
    • Journal Title

      Cell 137

      Pages: 487-497

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism and significance of specific proteolytic cleavage of Reelin2009

    • Author(s)
      Shiori Kohno, Takao Kohno, Yoshimi Nakano, Kenta Suzuki, Moe Ishii, Hideaki Tagami, Atsushi Baba and Mitsuharu Hattori
    • Journal Title

      Biochemical and Biophysical Research Communications 380

      Pages: 93-97

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism and significance of specific proteolytic cleavage of Reelin2009

    • Author(s)
      Shiori Kohno, et.al.
    • Journal Title

      Biochem Biophys Res Commun 380

      Pages: 93-97

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression2008

    • Author(s)
      Midori Shimada, Hiroyuki Niida, Doaa H. Zineldeen, Hideaki Tagami, Masafumi Tanaka, Hiroyuki Saito, and Makoto Nakanishi
    • Journal Title

      Cell 132

      Pages: 221-232

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chkl is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression2008

    • Author(s)
      Shimada, M., et. al.
    • Journal Title

      Cell 132

      Pages: 221-232

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An oncoprotein from the plant pathogen Agrobacterium has histone-chaperone-like activity2007

    • Author(s)
      Shinji Terakura, Yoshihisa Ueno, Hideaki Tagami, Saeko Kitakura, Chiyoko Machida, Hiroetsu Wabiko, Hiroji Aiba, Leon Otten, Hironaka Tsukagoshi, Kenzo Nakamura, and Yasunori Machida
    • Journal Title

      Plant Cell 19

      Pages: 2855-2865

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An oncoprotein from the plant pathogen Agrobacterium has histone-chaperone-like activity2007

    • Author(s)
      Terakura, S., et. al.
    • Journal Title

      Plant Cell 19

      Pages: 2855-2865

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規クロマチン因子Mlo2とヒストンH3/H4相互作用2009

    • Author(s)
      田上英明
    • Organizer
      遺伝研研究会「単細胞における複合システム系の連帯と統合」
    • Place of Presentation
      三島
    • Year and Date
      2009-03-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 新規クロマチン関連因子Mlo2とヒストンH3/H4相互作用2009

    • Author(s)
      保坂いづみ、田上英明
    • Organizer
      第26回染色体ワークショップ
    • Place of Presentation
      姫路
    • Year and Date
      2009-01-27
    • Related Report
      2008 Final Research Report
  • [Presentation] FACTは出芽酵母ヒストンH2A/H2Bダイナミクスを規定する2009

    • Author(s)
      田上英明、加藤麻希
    • Organizer
      第26回染色体ワークショップ
    • Place of Presentation
      姫路
    • Year and Date
      2009-01-26
    • Related Report
      2008 Final Research Report
  • [Presentation] FACTを介した酵母ヒストンH2A/H2Bダイナミクス2008

    • Author(s)
      田上英明
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 出芽酵母H2A-H2B複合体の分子解剖2008

    • Author(s)
      加藤麻希、田上英明
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Final Research Report
  • [Presentation] EACTを介した酵母ヒストンH2A/H2Bダイナミクス2008

    • Author(s)
      田上英明、加藤麻希
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酵母ヒストンH2A/H2Bから見るクロマチンダイナミクス2008

    • Author(s)
      田上英明
    • Organizer
      クロマチン研究会
    • Place of Presentation
      三島
    • Year and Date
      2008-10-22
    • Related Report
      2008 Final Research Report
  • [Presentation] FACT MEDIATES HISTONE H2A/H2B DYNAMICS IN YEAST2008

    • Author(s)
      Hideaki Tagami and Maki Kato
    • Organizer
      International Symposium on Chromosome Dynamics in Ise
    • Place of Presentation
      三重
    • Year and Date
      2008-05-28
    • Related Report
      2008 Final Research Report
  • [Book] 「S1マッピングによるRNA末端の決定」『RNA実験ノート』上無敵のバイオテクニカルシリーズ 稲田利文、塩見春彦 編2008

    • Author(s)
      田上英明
    • Publisher
      羊土社
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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