Investigation of molecular mechanisms of semaphorin signailing

• Project/Area Number: 19770174
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: TAKEGAHARA Noriko Osaka University, 微生物病研究所, 助教 (10444522)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 細胞内・細胞間情報伝達 / セマフォリン / 破骨細胞 / 免疫学 / 骨免疫学 / 細胞内シグナル伝達

Research Abstract

神経ガイダンス因子であるセマフォリン分子群は、近年、生体内において多彩な活性を有することが明らかとなっている。本研究ではセマフォリン分子群の主要な受容体分子Plexin-A1に着目し、その下流のシグナル伝達分子の機能解析を行うことにより、セマフォリン分子の有する多様な生物活性の機序の解明を試みた。細胞骨格の制御に関わる分子・Racの活性化因子であるFARP2がplexin-A1に会合し、破骨細胞の分化に関与することが明らかとなった。

Research Products

• [Journal Article] Involvement of Sema4A in the progression of experimental autoimmune myocarditis. (2008)
  • Author(s): Makino N, Toyofuku T, Takegahara N, (以下8名)
  • Journal Title: FEBS Lett. 582 Pages: 3935-40
  • Peer Reviewed
• [Journal Article] Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells. (2008)
  • Author(s): Toyofuku T, Yoshida J, Sugimoto T, Yamamoto M, Makino N, Takamatsu H, Takegahara N, (以下5 名)
  • Journal Title: Dev Biol. 321 Pages: 251-62
  • Peer Reviewed
• [Journal Article] Plexin-A4 negatively regulates T lymphocyte responses. (2008)
  • Author(s): Yamamoto M, Suzuki K, Okuno T, Ogata T, Takegahara N, (以下8 名)
  • Journal Title: Int Immunol. 20 Pages: 413-20
  • NAID: 10021240042
  • Peer Reviewed
• [Journal Article] Involvement of Sema4A in the progression of experimental autoimmune myocarditis (2008)
  • Author(s): Makino Nobuhiko
  • Journal Title: FEBS Letters 582 Pages: 3935-3940
  • Peer Reviewed
• [Journal Article] Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells (2008)
  • Author(s): Tovofuku Toshihiko
  • Journal Title: Developmental Biology 321 Pages: 251-262
  • Peer Reviewed
• [Journal Article] Plexin-A4 negatively regulates T lymphocytes responses (2008)
  • Author(s): Midori Yamamoto
  • Journal Title: Internal Immunology 20 Pages: 413-420
  • Peer Reviewed
• [Journal Article] Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. (2007)
  • Author(s): Suzuki K, Okuno T, Yamamoto M, Pasterkamp RJ, Takegahara N, (以下7 名)
  • Journal Title: Nature. 446 Pages: 680-4
  • Peer Reviewed
• [Presentation] Involvement of a guanine nucleotide exchange factor, FARP2, in osteoclastogenesis (2008)
  • Author(s): Takegahara Noriko
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-10
• [Presentation] Involvement of a guanine nucleotide exchange factor, FARP2, inosteoclastogenesis (2008)
  • Author(s): Takegahara Noriko
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-10
• [Presentation] A role of plexin-A4 in negative regulation of T cell responses (2007)
  • Author(s): Midori Yamamoto
  • Organizer: 日本免疫学会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-12-21