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Role of Lats2 in mammalian mitotic exit and cytokinesis.

Research Project

Project/Area Number 19770175
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionOsaka University

Principal Investigator

YABUTA Norikazu  Osaka University, 微生物病研究所, 助教 (10343245)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords細胞質分裂 / M期脱出 / Lats2 / Lats1 / Aurora / キナーゼ / リン酸化 / ノックアウトマウス / Aurora-A / 中心体
Research Abstract

細胞質分裂の制御異常は遺伝子的に非常に不安定な4倍体の形成を引き起こし、癌の悪性化を進行させる。本研究において、我々は独自の手法で単離し命名した癌抑制因子Lats2キナーゼがM 期キナーゼAurora-Aにより複数箇所リン酸化されて異なる分裂装置上へ局在し、新たな細胞質分裂のチェックポイント経路を構成していることを発見した。これらの成果は将来的に悪性癌の診断や治療に役立てられるものと期待できる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.2009

    • Author(s)
      Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson RO, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki EM, Nojima H, Rossant J, Nakao K, Niwa H, Sasaki H.
    • Journal Title

      Dev. Cell 16

      Pages: 398-410

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Hippo signaling pathway components Lats and Yap pat tern Tead4 activity to distinguish mouse trophectoderm from inner cell mass2009

    • Author(s)
      Nishioka, N., et.al.
    • Journal Title

      Developmental Cell (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lats2 is a negative regulator of myocyte size in the heart.2008

    • Author(s)
      Matsui Y, Nakano N, Shao D, Gao S, Luo W, Hong C, Zhai P, Holle E, Yu X, Yabuta N, Tao W, Wagner T, Nojima H, Sadoshima J.
    • Journal Title

      Circ. Res. 103

      Pages: 1309-1318

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lats2 is a negative regulator of myocyte size in the heart2008

    • Author(s)
      Matsui, Y., et.al.
    • Journal Title

      Circulation Research 103

      Pages: 1309-1318

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lats2 is an essential mitotic regulator required for the coordination of cell division.2007

    • Author(s)
      Yabuta N, Okada N, Ito A, Hosomi T, Nishihara S, Sasayama Y, Fujimori A, Okuzaki D, Zhao H, Ikawa M, Okabe M, Nojima H.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 19259-19271

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lats2 is an essential mitotic regulator required for the coordination of cell division.2007

    • Author(s)
      Yabuta, N., Okada, N., Ito, A., Hosomi, T., Nishihara, S., Sasayama, Y., Fujimori, A., Okuzaki, D., Zhao, H., Ikawa, M., Okabe, M., Nojima, H
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 19259-19271

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oleamide derivatives suppress the spontaneous metastasis by inhibiting connexin 26.2007

    • Author(s)
      Ohba, Y., Kanao, Y., Morita, N., Fujii, E., Hohrai, M., Takatsuji, M., Hirose, H., Miura, D., Watari, A., Yutsudo, M., Zhao, H., Yabuta, N., Ito, A., Kita, Y., Nojima, H.
    • Journal Title

      International Journal of Cancer 121

      Pages: 47-54

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of N-functional oleamide derivatives.2007

    • Author(s)
      Ohba, Y., Kanao, Y., Takatsuji, M., Ito, M., Yabuta, N., Nojima, H., Kita, Y.
    • Journal Title

      Tetrahedron 63

      Pages: 3754-3761

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Lats2はM期においてAurora-Aキナーゼによってリン酸化されて多様な局在を示す2008

    • Author(s)
      藪田紀一、岡田宣宏、野島博
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Lats1とLats2キナーゼは相互作用して機能を相補する2008

    • Author(s)
      佐藤愛、岡田宣宏、藪田紀一、野島博
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Lats2はM期においてAurora-Aキナーゼによってリン酸化されて多様な局在を示す2008

    • Author(s)
      藪田紀一
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同年会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lats1とLats2キナーゼは相互作用して機能を相補する2008

    • Author(s)
      佐藤愛
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同年会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aurora-Aによる多様なリン酸化はLats2のM期局在を制御する2008

    • Author(s)
      藪田紀一、岡田宣宏、野島博
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Aurora-Aによる多様なリン酸化はLats2のM期局在を制御する2008

    • Author(s)
      藪田紀一
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aurora-Aによるリン酸化はM期におけるLats2の多様な局在を制御する2008

    • Author(s)
      藪田紀一、岡田宣宏、野島博
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Aurora-Aによるリン酸化はM期におけるLats2の多様な局在を制御する2008

    • Author(s)
      藪田紀一
    • Organizer
      窮60回日本細胞生物学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Remarks] 所属研究室ホームページ

    • URL

      http://www.biken.osaka-u.ac.jp/lab/molgenet/

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/lab/molgenet/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/lab/molgenet/

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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