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Influence of co-culture with germ cellsthat exert on genomic imprinting of imprinted genes

Research Project

Project/Area Number 19770188
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionGunma University

Principal Investigator

HORII Takuro  Gunma University, 生体調節研究所, 助教 (00361387)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,750,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsインプリンティング / 刷り込み / 始原生殖細胞 / ES細胞 / EG細胞 / 生殖原基 / インプリンテング / 始原生細胞
Research Abstract

生殖細胞の性特異的なゲノムの刷り込みはマウスの場合、妊娠8.5-12.5日の間に生じる。しかし、そのような修飾が遺伝的に決まっているのか、周囲の環境によって決まるのか明らかではない。我々は妊娠8.5日目の始原生殖細胞より樹立した生殖幹細胞を異性の生殖原基と培養することで性特異的なゲノムの刷り込みを変化させることができるのか調べた。その結果、少なくとも8.5日目の始原生殖細胞由来生殖幹細胞ではすでに運命が決定されていることが分かった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Derivation of Embryonic Stem Cells from Mouse Tetraploid Embryos and Their Character2008

    • Author(s)
      Horii T, Kimura M, Morita S, Nagao Y, and Hatada I
    • Journal Title

      Biol Reprod. special issue

      Pages: 118-118

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Genomic Imprinting in Mouse Parthenogenetic Embryonic Stem Cells2008

    • Author(s)
      Horii T, Kimura M, Morita S, Nagao Y, Hatada I
    • Journal Title

      Stem Cells 26

      Pages: 79-88

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of Embryonic Stem Cells from Mouse Tetraploid Embryos and Their Character2008

    • Author(s)
      Horii T, Kimura M, Morita S, Yanagisawa E, Nagao Y, Hatada I
    • Journal Title

      Biology of Reproduction (Special issue)

      Pages: 118-118

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Genomic Imprinting in Mouse Parthenogenetic Embryonic Stem Cells.2008

    • Author(s)
      Horii T, Kimura M, Morita S, Nagao Y, Hatada I
    • Journal Title

      Stem Cells 26

      Pages: 79-88

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of imprints of parthenogenetic ES cells in murine chimeras2007

    • Author(s)
      Horii T, Kimura M Nagao Y and Hatada I
    • Journal Title

      Reprod. Fetil. Dev 19

      Pages: 228-228

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] マウス四倍体ES細胞の樹立とその性質2008

    • Author(s)
      堀居拓郎、木村美香、森田純代、柳澤永吉、長尾恭光、畑田出穂
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] Derivation of Embryonic Stem Cells from Mouse Tetraploid Embryos and Their Character2008

    • Author(s)
      Horii T, Kimura M, Morita S, Nagao Y, and Hatada I
    • Organizer
      The 41st Society for the study of reproduction
    • Place of Presentation
      Hawaii
    • Related Report
      2008 Final Research Report
  • [Presentation] Derivation of Embryonic Stem Cells from Mouse Tetraploid Embr yos and Their Character2008

    • Author(s)
      Horii T, Kimura M, Morita S, Yanagisawa E, Nagao Y, Hatada I
    • Organizer
      41th annual meeting society for the study of reproduction
    • Place of Presentation
      コナ、アメリカ合衆国
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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