| Budget Amount *help |
¥3,210,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Research Abstract |
Skeletal muscle stem cells, usually called satellite cells, play central roles in skeletal muscle repair and regeneration. The self-renewal of satellite cells supports a remarkable regenerative potential of skeletal muscle. In this research, it was demonstrated that formation of reserve cells, which are quiescent and undifferentiated C2C12 myogenic cells, were controlled by Grb2-Sos-Ras mediated signaling pathways, suggesting that skeletal muscle satellite cells are maintained as a result of quiescence of activated satellite cells via those signaling pathways.
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