Studies of molecular mechanisms in satellite cell self-renewal
Project/Area Number |
19770189
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Developmental biology
|
Research Institution | The University of Tokyo |
Principal Investigator |
NAGATA Yosuke The University of Tokyo, 教養学部, 特任助教 (50401211)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,210,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
Keywords | 細胞・組織 / 移植・再生医療 / 再生医学 / 発生・分化 / シグナル伝達 / 筋衛星細胞 / 自己複製 / シグナル伝逹 |
Research Abstract |
Skeletal muscle stem cells, usually called satellite cells, play central roles in skeletal muscle repair and regeneration. The self-renewal of satellite cells supports a remarkable regenerative potential of skeletal muscle. In this research, it was demonstrated that formation of reserve cells, which are quiescent and undifferentiated C2C12 myogenic cells, were controlled by Grb2-Sos-Ras mediated signaling pathways, suggesting that skeletal muscle satellite cells are maintained as a result of quiescence of activated satellite cells via those signaling pathways.
|
Report
(4 results)
Research Products
(13 results)