Interaction between the neuroepithelium and the motor neurons in zebrafish hindbrain
| Project/Area Number |
19770204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Niigata University |
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Principal Investigator |
WADA Hironor Niigata University, 個体遺伝研究系, さきがけ研究員 (70322708)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | 形態形成 / 細胞間相互作用 / 脳・神経 / 発生・分化 / シグナル伝達 / ゼブラフィッシュ / PCPパスウェイ / 側線 / 感丘 |
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| Research Abstract |
We showed that the lateral line mechanosensory receptors, neuromasts, migrate across the epidermal cell layer, which resembles migration of the motor neurons across the neuroepithelial cell layer (Wada et al., 2008). By taking advantage of easy accessibility of the lateral line system, we revealed that the nueromast gives rise to new neuromast by a budding process. We also showed that the difference in morphogenesis of the underlying dermal bones would be sufficient to account for the corresponding difference in the lateral line pattern (Wada et al., 2010). These results suggest that the interaction between the neuromast cells and epidermal cells is important for pattern formation of the lateral line system.
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Report
(4 results)
Research Products
(21 results)
