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Interaction between the neuroepithelium and the motor neurons in zebrafish hindbrain

Research Project

Project/Area Number 19770204
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionNiigata University

Principal Investigator

WADA Hironor  Niigata University, 個体遺伝研究系, さきがけ研究員 (70322708)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords形態形成 / 細胞間相互作用 / 脳・神経 / 発生・分化 / シグナル伝達 / ゼブラフィッシュ / PCPパスウェイ / 側線 / 感丘
Research Abstract

We showed that the lateral line mechanosensory receptors, neuromasts, migrate across the epidermal cell layer, which resembles migration of the motor neurons across the neuroepithelial cell layer (Wada et al., 2008). By taking advantage of easy accessibility of the lateral line system, we revealed that the nueromast gives rise to new neuromast by a budding process. We also showed that the difference in morphogenesis of the underlying dermal bones would be sufficient to account for the corresponding difference in the lateral line pattern (Wada et al., 2010). These results suggest that the interaction between the neuromast cells and epidermal cells is important for pattern formation of the lateral line system.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008 2007 Other

All Journal Article (12 results) (of which Peer Reviewed: 5 results) Presentation (9 results)

  • [Journal Article] Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish.2010

    • Author(s)
      Wada H, Ghysen A, Satou C, Higashijima S, Kawakami K, Hamaguchi S, Sakaizumi M
    • Journal Title

      Dev. Biol. 340

      Pages: 583-594

    • Related Report
      2009 Final Research Report
  • [Journal Article] Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish2010

    • Author(s)
      Wada et al
    • Journal Title

      Developmental Biology 340

      Pages: 538-594

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Planar Cell Polarity (PCP) Pathway Genes for Neuronal Migration and Differentiation.2009

    • Author(s)
      Wada H, Okamoto H.
    • Journal Title

      Develop. Growth Differ. 51

      Pages: 233-240

    • Related Report
      2009 Final Research Report
  • [Journal Article] Roles of Non-canonical Wnt/PCP Pathway Genes in Neuronal Migration and Neurulation in Zebrafish.2009

    • Author(s)
      Wada H, Okamoto H.
    • Journal Title

      Zebrafish 6

      Pages: 3-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] Flamingo regulates epibody and convergent/extension movements through cell cohesive and signaling functions during zebrafish gastrulation.2009

    • Author(s)
      Carreira-Barbosa F, Kajita M, Morel V, Wada H, Okamoto H, Arias A, Fujita Y, Wilson S, Tada M
    • Journal Title

      Development 136

      Pages: 383-392

    • Related Report
      2009 Final Research Report
  • [Journal Article] Roles of Planar Cell Polarity (PCP) Pathway Genes for Neuronal Migration and Differentiation2009

    • Author(s)
      Wada and Okamoto
    • Journal Title

      Development, Growth & Differentiation 51

      Pages: 233-240

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Non-canonical Wnt/PCP Pathway Genes in Neuronal Migration and Neurulation in Zebrafish2009

    • Author(s)
      Wada and Okamoto
    • Journal Title

      Zebrafish (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of diverse lateral line patterns on the teleost caudal fin.2008

    • Author(s)
      Wada H, Hamaguchi S, Sakaizumi M
    • Journal Title

      Dev. Dyn. 237

      Pages: 2889-2902

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of diverse lateral line patterns on the teleost caudal fin2008

    • Author(s)
      Wada, et.al.
    • Journal Title

      Developmental Dynamics 237

      Pages: 2889-2902

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel mutations affecting axon guidance in zebrafish and a role for plexin signaling in the guidance of trigeminal and facial nerve axons.2007

    • Author(s)
      anaka H, Maeda R, Shoji W, Wada H, Masai I, Shiraki T, Kobayashi M, Nakayama R, Okamoto H.
    • Journal Title

      Development 134

      Pages: 3259-3269

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel mutations affecting axon guidance in zebrafish and a role for plexin signaling in the guidance of trigeminal and facial nerve axons2007

    • Author(s)
      Tanaka H, et. al.
    • Journal Title

      Development 134

      Pages: 3259-3269

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain.

    • Author(s)
      Ohata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S, Tsuboi T, Watabe S, Okamoto H
    • Journal Title

      Development 136

      Pages: 1653-63

    • Related Report
      2009 Final Research Report
  • [Presentation] 魚類における多様な側線パターンの形成機構2010

    • Author(s)
      和田浩則
    • Organizer
      第115回日本解剖学会シンポジウム
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 魚類における多様な側線パターンの形成機構。2010

    • Author(s)
      和田浩則
    • Organizer
      第115回日本解剖学会シンポジウム
    • Place of Presentation
      盛岡
    • Related Report
      2009 Final Research Report
  • [Presentation] 魚類における多様な側線パターンの形成機構2010

    • Author(s)
      和田浩則
    • Organizer
      第9回シンポジウム「水生動物の行動と神経系」
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Developmental mechanisms underlying diverse lateral line patterns in teleosts2009

    • Author(s)
      和田浩則
    • Organizer
      第42回日本発生生物学会シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 魚類側線パターンの種間多様性を制御する発生メカニズム2009

    • Author(s)
      和田浩則
    • Organizer
      NIG Zebrafish Meeting 2009
    • Place of Presentation
      三島
    • Year and Date
      2009-03-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Developmental mechanisms underlying diverse lateral line patterns in teleosts.2009

    • Author(s)
      Hironori Wada.
    • Organizer
      第42回日本発生生物学会・シンポジウム:「遺伝的多型性の発生学」
    • Place of Presentation
      新潟
    • Related Report
      2009 Final Research Report
  • [Presentation] Developmental mechanisms regulating species-specific lateral line patterns of the teleost caudal fin2008

    • Author(s)
      Wada et al
    • Organizer
      第41回日本発生生物学会
    • Place of Presentation
      徳島
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Planar Cell Polarity (PCP)遺伝子群の働きによって神経上皮細胞層が運動神経細胞の侵入を阻害するメカニズム。2007

    • Author(s)
      和田浩則、田中英臣、中山里実、岩崎 美樹、岡本仁
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会・合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Planar Cell Polarity(PCP)遺伝子群の働きによって神経上皮細胞層が運動神経細胞の侵入を阻害するメカニズム2007

    • Author(s)
      和田浩則, 他
    • Organizer
      第40回 日本発生生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-28
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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