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Studies on the regulation of apoptosis through the protein disulfide bond formation.

Research Project

Project/Area Number 19780079
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied biochemistry
Research InstitutionNational Institute for Longevity Sciences,NCGG

Principal Investigator

HOSONO Takashi  National Institute for Longevity Sciences,NCGG, アルツハイマー病研究部, 外来研究員 (80445741)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,790,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywords酸化ストレス / ジスルフィド結合 / アポトーシス / ジスルフイド結合
Research Abstract

酸化ストレスは、生体に様々な影響を及ぼすことが報告されているが、その直接的な標的タンパク質についての検討は少ない。本研究では、酸化ストレスによって誘導されるタンパク質のジスルフィド結合形成が、細胞周期の停止やアポトーシスの誘導を引き起こすこと、酸化ストレスの標的タンパク質としてβ-tubulin とthioredoxinを見出したこと、酸化ストレスが複数のタンパク質にジスルフィド結合形成を誘導することを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (15 results)

  • [Journal Article] Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells.2008

    • Author(s)
      Hosono T, Hosono-Fukao T, Inada K, Tanaka R, Yamada H, Iitsuka Y, Seki T, Hasegawa I, Ariga T.
    • Journal Title

      Carcinogenesis 29

      Pages: 1400-1406

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anticancer effects of diallyl trisulfide derived from garlic.2008

    • Author(s)
      Seki T, Hosono T, Hosono-Fukao T, Inada K, Tanaka R, Ogihara J, Ariga T.
    • Journal Title

      Asia Pac J Clin Nutr. 17 suppl1

      Pages: 249-252

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells.2008

    • Author(s)
      Takashi Hosono
    • Journal Title

      Carcinogenesis 29

      Pages: 1400-1406

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anticancer effects of diallyl trisulfide derived from garlic.2008

    • Author(s)
      Taiichiro Seki
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition 17

      Pages: 249-252

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ネギ属植物に含まれるsulfide類の構造と機能の違いについて2009

    • Author(s)
      飯塚裕司
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Diallyl trisulfide(DATS)によるヒト白血病細胞株のアポトーシス誘導機構2009

    • Author(s)
      稲田薫
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] ガーリック由来香気成分Diallyl trisulfideの分子標的の解析2009

    • Author(s)
      田中理江
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Diallyl trisulfide (DATS)によるヒト白血病細胞株のアポトーシス誘導機構2009

    • Author(s)
      稲田薫
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Diallyl trisulfideによるヒト単球性白血病細胞U937アポトーシス誘導 機構2008

    • Author(s)
      稲田薫
    • Organizer
      第31回日本分子生物学会年会第81回日本生化学会大会合同大会 (BMB2008)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Dialyl trisulfideによるヒト単球性白血病細胞U937アポトーシス誘導機構2008

    • Author(s)
      稲田薫
    • Organizer
      第31回日本分子生物学会年会 第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニンニク由来香気成分ジアリルトリスルフィドが誘導する各種白血病細胞株のアポトーシスについて2008

    • Author(s)
      田中理江
    • Organizer
      第23回日本香辛料研究会学術講演会
    • Place of Presentation
      金沢
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Diallyl trisulfideによる微小管形成阻害機構に関する研究2008

    • Author(s)
      山田晴久
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Diallyl trisulfideはヒト単球性白血病細胞U937にアポトーシスを誘導する2008

    • Author(s)
      稲田薫
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Diallyl trisulfideがヒト急性前骨髄球性白血病細胞に及ぼす影響2008

    • Author(s)
      嶌本麻衣子
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Anticancer effects of diallyl trisulfide derived from garlic.2007

    • Author(s)
      Seki T
    • Organizer
      International Conference on Food Factors for Health Promotion (ICoFF2007)
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-11-30
    • Related Report
      2008 Final Research Report
  • [Presentation] ガーリック香気成分diallyl trisulfideによるヒト大腸がん細胞株の増殖抑制機構の解析2007

    • Author(s)
      細野(深尾)友美
    • Organizer
      日本農芸化学会関東支部2007年度大会
    • Place of Presentation
      宇都宮
    • Year and Date
      2007-11-10
    • Related Report
      2008 Final Research Report
  • [Presentation] alk(en)yl trisulfide が大腸がん細胞株HT-29の細胞増殖と微小管に及ぼす影響2007

    • Author(s)
      細野(深尾)友美
    • Organizer
      第22回日本香辛料研究会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2007-09-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Anticancer effects of diallyl trisulfide derived from garlic.2007

    • Author(s)
      Seki T
    • Organizer
      10th Asian Congress of Nutrition (10th ACN)
    • Place of Presentation
      Taipei
    • Year and Date
      2007-09-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Structure-function relationship of alk(en)yl sulfides in the induction and suppression of drug-metabolizing enzymes.2007

    • Author(s)
      Fukao T
    • Organizer
      10th Asian Congress of Nutrition (10th ACN)
    • Place of Presentation
      Taipei
    • Year and Date
      2007-09-11
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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