Search and biosynthesis of novel cyclic C35-terpenes produced by Mycobacterium
| Project/Area Number |
19780085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Niigata University |
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Principal Investigator |
SATO Tsutomu Niigata University, 自然科学系, 准教授 (80334655)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,750,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | テルペン / イソプレノイド / テルペン環化酵素 / Mycobacterium / マイコバクテリア / 生合成 |
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| Research Abstract |
2つの新規環状C35テルペンを発見した。また、環状C35 テルペンが直鎖状C35イソプレノイドの環化によって生合成されることを証明した。そのような証明が成されている天然物は他に例がない。M. chlorophenolicum とM. vanbaalenii から合計5種類のZ型プレニル鎖延長酵素遺伝子を見出した。M. vanbaalenii 由来の2種類は機能解析でき、各々主にC35 とC15 を生産することが判明した。
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid produced by VioABDE, and insight into VioC function2007
Author(s)
Shinoda, K., Hasegawa, T., Sato, H., Shinozaki, M., Kuramoto, H., Takamiya, Y., Sato, T., Nikaidou, N., Watanabe, T., and Hoshino, T
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Journal Title
Chem. Commun
Pages: 4140-4142
NAID
Related Report
Peer Reviewed
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[Journal Article] Biosynthesis of violacein:a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function.2007
Author(s)
Shinoda K, Hasegawa T, Sato H, Shinozaki M, Kuramoto H, Takamiya Y, Sato T, Nikaidou N, Watanabe T, Hoshino T.
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Journal Title
Chem. Commun. 2
Pages: 4140-4142
Related Report
Peer Reviewed
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