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Study on synergistic effect of flavonoids and other compounds on availability of flavonoids in vivo

Research Project

Project/Area Number 19780092
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionTohoku University

Principal Investigator

NAKAGAWA Kiyotaka  Tohoku University, 大学院・農学研究科, 准教授 (80361145)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,350,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsエピガロカテキンガレート / カフェイン / フラボノイド / 吸収代謝 / 抱合化 / 生理機能向上 / 茶カテキン / 高感度分析法
Research Abstract

We had previously developed a method of food flvonoids. By using the method, in this study, we investigated whether food constituents (e.g., caffeine) affects the bioavailability of flavonoids in vivo. As results, a higher concentration of flavonoid (i.e., catechin) was observed when catechin and caffeine were co-administered to humans. The result provides new insight into the synergistic effect of flavonoids and other compounds on availability of flavonoids in vivo.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Effect of co-administration of tea epigallocatechin-3-gallate (EGCG) and caffeine on absorption and metabolism of EGCG in human.2009

    • Author(s)
      K. Nakagawa, K. Nakayama, M. Nakamura, P. Sookwong, T. Tsuduki, H. Niino, F. Kimura, T. Miyazawa
    • Journal Title

      Biosci. Biotech. Bioch. 73

      Pages: 2014-2017

    • NAID

      10027545591

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 栄養生理作用解明のための食品と生体成分の分析法開発.2009

    • Author(s)
      仲川清隆
    • Journal Title

      日本栄養・食糧学会誌 62

      Pages: 113-121

    • NAID

      10024794854

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of co-administration of tea epigallocatechin-3-gallate(EGCG)and caffeine on absorption and metabolism of EGCG in human2009

    • Author(s)
      K.Nakagawa, K.Nakayama, M.Nakamura, P.Sookwong, T.Tsuduki, H.Niino, F.Kimura, T.Miyazawa
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry 73

      Pages: 2014-2017

    • NAID

      10027545591

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 栄養生理作用解明のための食品と生体成分の分析法開発2009

    • Author(s)
      仲川清隆
    • Journal Title

      日本栄養・食糧学会誌 62

      Pages: 113-121

    • NAID

      10024794854

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin.2007

    • Author(s)
      Nakagawa K, Ibusuki D, Suzuki Y, Yamashita S, Higuchi O, Oikawa S, Miyazawa T.
    • Journal Title

      J. Lipid Res. 48(12)

      Pages: 2779-2787

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 栄養生理作用解明のための食品と生体成分の分析法開発

    • Author(s)
      仲川清隆
    • Journal Title

      日本栄養・食糧学会誌 (印刷中)

    • NAID

      10024794854

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高速液体クロマトグラフ-質量分析装置による脂質分析と栄養・食糧研究への活用2009

    • Author(s)
      仲川清隆
    • Organizer
      4th JOCS-ILSI Japan Joint Symposium 2009
    • Place of Presentation
      東京
    • Year and Date
      2009-11-07
    • Related Report
      2009 Final Research Report
  • [Presentation] 高速液体クロマトグラフー質量分析装置による脂質分析と栄養・食糧研究への活用2009

    • Author(s)
      仲川清隆
    • Organizer
      4th JOCS-ILSI Japan Joint Symposium 2009
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生物産業創成を視野に入れた食品・生体成分の分析法開発2008

    • Author(s)
      仲川清隆
    • Organizer
      食品分析研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-10
    • Related Report
      2009 Final Research Report
  • [Presentation] 生物産業創成を視野に入れた食品・生体成分の分析法開発2008

    • Author(s)
      仲川清隆
    • Organizer
      食品分析研究会
    • Place of Presentation
      東洋大学(東京)
    • Year and Date
      2008-09-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin2007

    • Author(s)
      仲川清隆
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] カフェイン摂取によるラットとヒトのカテキン吸収動態の変化2007

    • Author(s)
      中村美穂, 仲川清隆, 新納仁, 角田隆巳, 宮澤陽夫
    • Organizer
      第61回栄養・食糧学会本大会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-18
    • Related Report
      2009 Final Research Report
  • [Presentation] カフェイン摂取によるラットとヒトのカテキン吸収動態の変化2007

    • Author(s)
      中村美穂
    • Organizer
      第61回栄養・食糧学会本大会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2007-05-18
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/kinoubunshi/index-j.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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