Studies on the mechanism of uptake and intracellular dynamics of nicotinic acid and nicotinamide in human cells
| Project/Area Number |
19780095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Mie University |
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Principal Investigator |
OGATA Shin Mie University, 大学院・生物資源学研究科, 助教 (70324556)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,960,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | ニコチン酸 / ニコチンアミド / NAD / 動物培養細胞 / PARP / Sirtuin / アフィニティビーズ / 免疫染色法 / ビタミン / アフィニティービーズ / PARP-1 / PARP-2 |
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| Research Abstract |
Nicotinic acid and nicotinamide are one of water-soluble vitamins and have various physiological functions in mammals. However, the mechanism of uptake and intracellular dynamics of nicotinic acid and nicotinamide are unknown. Especially, it was suggested that nicotinamide and its related compounds were localized in mitochondoria by immunostaing analyses. However, related factors were not identifiable.
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Report
(6 results)
Research Products
(50 results)
