Regulation of chemokine involved in the inflammatory diseases in obesity by Japanese-style foods

• Project/Area Number: 19780096
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Kyoto University
• Principal Investigator: HIRAI Shizuka Kyoto University, 農学研究科, 産学官連携研究員 (90432343)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,670,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥2,500,000 (Direct Cost: ¥2,500,000)
• Keywords: 日本型食品 / 肥満 / 炎症 / MCP-1 / TNF-α / 脂肪細胞 / マクロファージ / ジオスゲニン / 食品 / ナリンゲニン類 / デビドロアビエチン酸

Research Abstract

糖尿病などの肥満に伴う炎症性疾患の発症メカニズムの解明と日本型食品由来成分によるその制御を目的に、野菜を中心とした日本型食品中より機能性成分を探索した。その結果、カレーの香辛料であるフェヌグリーク中のジオスゲニン、トマトの果皮に含まれるナリンゲニンカルコン、松樹脂に含まれるデヒドロアビエチン酸が脂肪組織の炎症反応を抑制する活性を持つことをそのメカニズムとともに明らかにした。さらにナスからは脂肪酸関連の新規候補物質を見出した。

Research Products

• [Journal Article] Auraptene, a citrus fruit compound, regulates gene expression as a PPARα agonist in HepG2 hepatocytes. (2008)
  • Author(s): Takahashi N, Kang MS, Kuroyanagi K, Goto T, Hirai S, Ohyama K, Lee JY, Yu R, Yano M, Sasaki T, Murakami S, Kawada T.
  • Journal Title: BioFactors 33 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Dietary regulation of nuclear receptors in obesity related metabolic syndrome (2008)
  • Author(s): Kawada T, Goto T, Hirai S, Kang MS, emura T, Yu R, Takahashi N.
  • Journal Title: Asia Pacific Journal of Clinical Nutrition 17 Pages: 126-130
  • Peer Reviewed
• [Journal Article] Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation (2008)
  • Author(s): Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T.
  • Journal Title: Biochemical and Biophysical Research Communications 369 Pages: 333-338
  • Peer Reviewed
• [Journal Article] Dietary,regulation of nuclear receptors in obesity-related metabolic syndrome (2008)
  • Author(s): Kawada T, Goto T, Hirai S, Kang MS, Uemura T, Yu R, Takahashi N.
  • Journal Title: Asia Pacific Journal of Clinical Nutrition 17 Pages: 126-130
  • Peer Reviewed
• [Journal Article] Auraptene, a citrus fruit compound, regulates gene expression as a PPARα agonist in HepG2 hepatocytes. (2008)
  • Author(s): Takahashi N, Kang MS, Kuroyanagi K, Goto T, Hirai S, Ohyama K, Lee JY, Yu R, Yano M, Sasaki T, Murakami S, Kawada T
  • Journal Title: BioFactors 33 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. (2008)
  • Author(s): Kang MS, Hirai S, Goto T, Kuroyanagi K, Lee JY, Uemura T, Ezaki Y, Takahashi N, Kawada T
  • Journal Title: Biochemical and Biophysical Research Communications 369 Pages: 333-338
  • Peer Reviewed
• [Journal Article] Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages (2007)
  • Author(s): Hirai S, Kim YI, Goto T, Kang MS, Yoshimura M, Obata A, Yu R, Kawada T.
  • Journal Title: Life Sciences 82 Pages: 1272-1279
  • Peer Reviewed
• [Journal Article] Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. (2007)
  • Author(s): Hirai S, Kim YI, Goto T, Kang MS, Yoshimura M, Obata A, Yu R, Kawada T
  • Journal Title: Life Sciences 81 Pages: 1272-1279
  • Peer Reviewed
• [Presentation] 肥満関連炎症性サイトカインに対するステロイドサポニン、ジオスゲニンの分泌抑制作用 (2008)
  • Author(s): 溝口典子, 平井静, 植村卓, 中野雄喜, 正野仁慈, 星野彰平, 柘植信昭, 鳴神寿彦, 高橋信之, 河田照雄
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分県大分市
• [Presentation] 肥満関連炎症性サイトカインに対するステロイドサポニン、ジオスゲニンの分泌抑制作用 (2008)
  • Author(s): 溝口典子、平井静、植村卓、中野雄喜、正野仁慈、星野彰平、柘槙信昭、鳴神寿彦、高橋信之、河田照雄
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分県、大分市
• [Presentation] Inhibitory effect of naringenin chalcone on the inflammatory changes in the interaction between adipocytes and macrophages (2007)
  • Author(s): Hirai S, Kim YI, Goto T, Kang MS, Yoshimura M, Obata A, Kawada T.
  • Organizer: 3rd International Conference on Polyphenols and Health
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan
• [Presentation] Inhibitory effect of naringenin chalcone on the inflammatory changes in the interaction between adipocytes and macrophages (2007)
  • Author(s): Hirai S, Kim YI, Goto T, Kang MS, Kawada T
  • Organizer: 10th Asian Congress of Nutrition
  • Place of Presentation: Taipei International Convention Center, Taipei, Taiwan
• [Presentation] Inhibitory effect of naringenin chalcone on the inflammatory changes in the interaction between adipocytes and macrophages. (2007)
  • Author(s): Hirai S, Kim YI, Goto T, Kang MS, Kawada T
  • Organizer: 10th Asian Congress of Nutrition
  • Place of Presentation: Taipei International Convention Center, Taipei, Taiwan
• [Presentation] Inhibitory effect of naringenin chalcone on the inflammatory changes in the interaction between adipocytes and macrophages. (2007)
  • Author(s): Hirai S, Kim YI, Goto T, Kang MS, Yoshimura M, Obata A, Kawada T
  • Organizer: 3rd International Conference on Polyphenols and Health
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan
• [Book] Food Factors for Health Promotion "Genomics: 3.Genome science of lipid metabolism and obesity" (2009)
  • Author(s): Nobuyuki Takahashi, Tsuyoshi Goto, Shizuka Hirai, Taku Uemura, Teruo Kawada
  • Publisher: Karger
• [Book] 「Nutrigenomics and proteomics in nealth and Deseases. Food Factors and Gene Interactions.」 "4 Obesity and Nuclear Receptors : Effective Genomic Strategies in Functional Foods" "20 Isoprenols" (2009)
  • Author(s): Teruo Kawada, Tsuyoshi Goto, Shizuka Hirai, Rina Yu, Nobuyuki Takahashi
  • Publisher: Blackwell Publishing
• [Book] Tood Factors for Health Promotion」 "Genomics : 3.Genome science of lipid metabolism and obesity" (2009)
  • Author(s): Nobuyuki Takahashi, Tsuyoshi Goto, Shizuka Hirai, Taku Uemura, Teruo Kawada
  • Publisher: Karget
• [Book] Nutrigenomics and Proteomics in Health and Deseases: Food Factors and Gene Interactions, "4 Obesity and Nuclear Receptors: Effective Genomic Strategies in Functional Foods", "20 Isoprenols" (2008)
  • Author(s): Teruo Kawada, Tsuyoshi Goto, Shizuka Hirai, Rina Yu, Nobuyuki Takahashi
  • Publisher: Blackwell Publishing
• [Book] 肥満と脂肪エネルギー代謝-メタボリックシンドロームへの戦略-「第11章 肥満・メタボリックシンドロームと食品機能」 (2008)
  • Author(s): 平井静, 後藤剛, 柳梨娜, 高橋信之, 河田照雄
  • Publisher: 建帛社
• [Book] Functional Food 2 : 9 肥満と食品機能成分-脂肪細胞の特性とその形成制御機構 (2008)
  • Author(s): 平井 静, 柳梨娜, 河田照雄
  • Publisher: フジメディカル出版
• [Book] 肥満と脂肪エネルギー代謝-メタボリックシンドロームへの戦略-「第11章肥満・メタボリシクシンドロームと食品機能」 (2008)
  • Author(s): 平井静、後藤剛、柳梨娜、高橋信之、河田照雄
  • Publisher: 建帛社
• [Book] Functional Food 2:9肥満と食品機能成分-脂肪細胞の特性とその形成制御機構 (2008)
  • Author(s): 平井 静、柳 梨娜、河田照雄
  • Total Pages: 7
  • Publisher: フジメディカル出版