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The molecular mechanism of the formation of myosin, actin and twitchin complex in bivalve catch muscle

Research Project

Project/Area Number 19780161
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fisheries chemistry
Research InstitutionMie University

Principal Investigator

FUNABARA Daisuke  Mie University, 大学院・生物資源学研究科, 准教授 (00335150)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsキャッチ筋 / トゥイッチン / ミオシン / アクチン / リン酸化 / 張力維持 / キャッチ収縮
Research Abstract

二枚貝キャッチ筋の張力維持機構を分子レベルで明らかにするために, キャッチ収縮制御タンパク質トゥイッチンの機能を解析した。非リン酸化状態のトゥイッチンは収縮タンパク質であるミオシンのループ2領域とアクチンのサブドメイン1領域に結合して3者で複合体を形成した。リン酸化状態のトゥイッチンでは複合体は形成しなかった。トゥイッチンはリン酸化によってその立体構造を変化させている可能性が分かった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (13 results)

  • [Journal Article] 二枚貝キャッチ運動の分子メカニズム2009

    • Author(s)
      舩原大輔
    • Journal Title

      溶接学会誌 78

      Pages: 25-29

    • NAID

      10025074379

    • Related Report
      2008 Final Research Report
  • [Journal Article] The occurrence of tissue-specific twitchin isoforms in the mussel Mytilus galloprovincialis.2008

    • Author(s)
      M. Kusaka, D. Ikeda, D. Funabara, S. Watabe.
    • Journal Title

      Fish. Sci. 74

      Pages: 677-686

    • NAID

      10020861307

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The occurrence of tissue-specific twitchin isoforms in the mussel Mytilus galloprovincialis2008

    • Author(s)
      Miho Kusaka, et. al.
    • Journal Title

      Fisheries Science (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unphosphorylated twitchin forms a complex with actin and myosin that may contribute to tension maintenance in catch.2007

    • Author(s)
      D. Funabara, C. Hamamoto, K. Yamamoto, A. Inoue, M. Ueda, R. Osawa, S. Kanoh, D. J. Hartshorne, S. Suzuki, S. Watabe.
    • Journal Title

      J. Exp. Biol. 210

      Pages: 4399-4410

    • NAID

      120000949468

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unphosphorylated twitchin forms a complex with actin and myosin that may contribute to tension maintenance in catch2007

    • Author(s)
      Daisuke Funabara, et. al.
    • Journal Title

      The Journal of Experimental Biology 210

      Pages: 4399-4410

    • NAID

      120000949468

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 二枚貝キャッチ筋トゥイッチンのリン酸化による立体構造の変化2009

    • Author(s)
      森井健太, 大澤里佳, 舩原大輔, 渡部終五, 加納哲
    • Organizer
      平成21年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学(東京都港区)
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Molecular Mechanism of Tension Maintenance in Catch Contraction in Invertebrate Smooth Muscle.2008

    • Author(s)
      D. Funabara, D. J. Hartshorne, S. Kanoh, S. Watabe.
    • Organizer
      第5回世界水産学会議
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2008-10-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Characterization of the Kinase Domain in Twitchin from Invertebrate Smooth Muscle.2008

    • Author(s)
      N. Morimoto, D. Funabara, S. Kanoh.
    • Organizer
      第5回世界水産学会議
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2008-10-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression Patterns of Paramyosin Gene in Molluscan Striated and Smooth Muscles.2008

    • Author(s)
      S. Rokubuichi, D. Funabara, S. Kanoh.
    • Organizer
      第5回世界水産学会議
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2008-10-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Characteristics of single cell isolated from molluscan smooth muscle osin Gene in Molluscan Striated and Smooth Muscles.2008

    • Author(s)
      T. Aoyama, D. Funabara, S. Kanoh.
    • Organizer
      第5回世界水産学会議
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2008-10-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular Mechanism of Tension Maintenance in Catch Contraction in Invertebrate Smooth Muscle2008

    • Author(s)
      D. Funabara, D. J. Hartshorne, S. Kanoh, S. Watabe
    • Organizer
      第5回世界水産学会議
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2008-10-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characterization of the Kinase Domain in Twitchin from Invertebrate Smooth Muscle2008

    • Author(s)
      N. Morimoto, D. Funabara, S .Kanoh
    • Organizer
      第5回世界水産学会議
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2008-10-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression Patterns of Paramyosin Gene in Molluscan Striated and Smooth Muscles2008

    • Author(s)
      S. Rokubuichi, D. Funabara, S. Kanoh
    • Organizer
      第5回世界水産学会議
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2008-10-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characteristics of single cell isolated from molluscan smooth muscle osin Gene in Molluscan Striated and Smooth Muscles2008

    • Author(s)
      T. Aoyama, D. Funabara, S. Kanoh
    • Organizer
      第5回世界水産学会議
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2008-10-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 二枚貝キャッチ筋ミオシン・アクチン・トゥイッチン複合体生成の熱力学的解析2008

    • Author(s)
      大澤里佳, 舩原大輔, 渡部終五, 加納哲
    • Organizer
      平成20年度日本水産学会春季大会
    • Place of Presentation
      東海大学(静岡県静岡市)
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 二枚貝キャッチ筋ミオシン・アクチン・トゥイッチン複合体生成の熱力学的解析2008

    • Author(s)
      舩原大輔
    • Organizer
      平成20年度日本水産学会春季大会
    • Place of Presentation
      静岡県静岡市
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] キャッチ筋twitchinのミオシンループ2領域とアクチンへの結合2008

    • Author(s)
      舩原大輔, 加納哲, David J. Hartshorne, 渡部終五
    • Organizer
      2008年生体運動研究合同班会議
    • Place of Presentation
      仙台市戦災復興記念館(宮城県仙台市)
    • Year and Date
      2008-01-08
    • Related Report
      2008 Final Research Report
  • [Presentation] キャッチ筋twitchinのミオシンループ2領域とアクチンへの結合2008

    • Author(s)
      舩原大輔
    • Organizer
      2008年生体運動研究合同班会議
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2008-01-08
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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