• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on the biological activity of furan fatty acids

Research Project

Project/Area Number 19780162
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fisheries chemistry
Research InstitutionUniversity of Shizuoka

Principal Investigator

WAKIMOTO Toshiyuki  University of Shizuoka, 薬学部, 講師 (70363900)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsフラン脂肪酸 / ミドリイガイ / 抗炎症活性
Research Abstract

Furan fatty acid is known as naturally occurring in various organisms but rare fatty acid. The elucidation of biological activity of furan fatty acid has been limited to antioxidant activity in vitro due to paucity of this fatty acid. In this study, isolation and semi-synthesis of this fatty acid were established, which enable us to disclose more potent anti-inflammatory activity of furan fatty acid than that of EPA.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008 2007

All Journal Article (18 results) (of which Peer Reviewed: 8 results) Presentation (12 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Modified Julia-Kocienski reaction promoted by means of m-NPT (Nitrophenyltetrazole) sulfone.2010

    • Author(s)
      Y. Sakai, K. Ikeuchi, Y. Yamada, T. Wakimoto, T. Kan
    • Journal Title

      Synlett 20

      Pages: 827-829

    • Related Report
      2009 Final Research Report
  • [Journal Article] Binding affinity of tea catechins for human serum albumin: characterization by high-performance affinity chromatography with immobilized albmin column.2010

    • Author(s)
      T. Ishii, K. Minoda, M. -J. Bae, T. Mori, Y. Uekusa, T. Ichikawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama
    • Journal Title

      Mol. Nutr. Food Res. 54

      Pages: 1-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Modified Julia-Kocienski Reaction promoted by means of m-NPT (Nitrop henyltetrazole) sulfone.2010

    • Author(s)
      Y.Sakia, K.Ikeuchi, Y.Yamada, T.Wakimaoto, T.Kan
    • Journal Title

      Synlett

      Pages: 827-829

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solid support synthesis of artificial phospholipids.2009

    • Author(s)
      T. Furuta, H. Onuki, M. Mochizuki, M. Ito, M. Inai, T. Wakimoto, T. Kan
    • Journal Title

      Synlett

      Pages: 3373-3377

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structure-activity relationship study onα1 adrenergic receptor antagonists from beer.2009

    • Author(s)
      T. Wakimoto, M. Nitta, T. Chiba, Y. Yiping, K. Tsuji, T. Kan, H. Nukaya, M. Ishiguro, M. Koike, Y. Yokoo, Y. Suwa
    • Journal Title

      Bioorg. Med. Chem. Lett. 19

      Pages: 5905-5908

    • Related Report
      2009 Final Research Report
  • [Journal Article] Quantitation of chafuroside A and B in tea leaves and isolation of prechafuroside A and B from oolong tea leaves.2009

    • Author(s)
      H. Ishida, T. Wakimoto, Y. Kitao, S. Tanaka, T. Miyase, H. Nuakaya
    • Journal Title

      J. Agric. Food. Chem. 57

      Pages: 6779-6786

    • Related Report
      2009 Final Research Report
  • [Journal Article] Regioselective synthesis of methylated epigallocatechin gallate via nitrobenxenesulfonyl (Ns) protectiong group.2009

    • Author(s)
      Y. Aihara, A. Yoshida, T. Furuta, T. Wakimoto, T. Akizawa, M. Konishi, T. Kan
    • Journal Title

      Bioorg. Med. Chem. Lett. 19

      Pages: 4171-4174

    • Related Report
      2009 Final Research Report
  • [Journal Article] Concise synthesis of chafuroside A and B.2009

    • Author(s)
      T. Furuta, M. Nakayama, H. Suzuki, H. Tajimi, M. Inai, H. Nukaya, T. Wakimoto, T. Kan
    • Journal Title

      Org. Lett. 11

      Pages: 2233-2236

    • Related Report
      2009 Final Research Report
  • [Journal Article] Solid support synthesis of artificial phospholipids.2009

    • Author(s)
      T.Furuta, H.Onuki, M.Mochizuki, M.Ito, M.Inai, T.Wakimoto, T.Kan
    • Journal Title

      Synlett

      Pages: 3373-3377

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship study on α 1 adrenergic receptor antangonists from beer.2009

    • Author(s)
      T.Wakimoto, M.Nitta, T.Chiba, Y.Yiping, K.Tsuji, T.Kan, H.Nukaya, M.Ishiguro, M.Koike, Y.Yokoo, Y.Suwa
    • Journal Title

      Bioorg.Med.Chem.Lett. 19

      Pages: 5905-5908

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitation of chafuroside A and B in tea leaves and isolation of prechafuroside A and B from oolong tea leaves.2009

    • Author(s)
      H.Ishida, T.Wakimoto, Y.Kitao, S.Tanaka, T.Miyase, H.Nuakaya
    • Journal Title

      J.Agric.Food.Chem. 57

      Pages: 6779-6786

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regioselective synthesis of methylated epigallocatechin gallate via nitrobe nxenesulfony1 (Ns) progectiong group.2009

    • Author(s)
      Y.Aihara, A.Yoshida, T.Furuta, T.Wakimoto, T.Akizawa, M.Konishi, T.Kan
    • Journal Title

      Bioorg.Med.Chem.Lett. 19

      Pages: 4171-4174

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concise synthesis of chafuroside A and B.2009

    • Author(s)
      T.Furuta, M.Nakayama, H.Suzuki, H.Tajimi, M.Inai, H.Nukaya, T.Wakimoto, T.Kan
    • Journal Title

      Org.Lett. 11

      Pages: 2233-2236

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereocontrolled total synthesis of (-)-myriocin.2008

    • Author(s)
      M. Inai, T. Goto, T. Furuta, T. Wakimoto, T. Kan
    • Journal Title

      Tetrahedron: Asymmetry 19

      Pages: 2771-2773

    • Related Report
      2009 Final Research Report
  • [Journal Article] Total synthesis of (-)-Serotobenine.2008

    • Author(s)
      Y. Koizumi, H. Kobayashi, T. Wakimoto, T. Furuta, T. Fukuyama, T. Kan
    • Journal Title

      J. Am. Chem. Soc. 130

      Pages: 16854-16855

    • Related Report
      2009 Final Research Report
  • [Journal Article] Total Synthesis of(-)-Serotobenine2008

    • Author(s)
      Koizumi, Y. ; Kobayashi, H. ; Wakimoto, T. ; Furuta, T. ; Fukuyama, T. ; Kan, T.
    • Journal Title

      J. Am. Chem. Soc 130

      Pages: 16854-16855

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereocontrolled Total Synthesis of (-)-Myriocin2008

    • Author(s)
      Inai, M. ; Goto, T. ; Furuta, T. ; Wakimot o, T. ; Kan, T.
    • Journal Title

      Tetrahedron Asymmetry 19

      Pages: 2771-2773

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Determination of Two Active Compounds Bind to the Muscarinic M3 receptor in Beer.2007

    • Author(s)
      N. Yamaji, Y. Yokoo, T. Iwashita, A. Nemoto, M. Koike, Y. Suwa, H. Masuya, T. Wakimoto, K. Tsuji, H. Nukaya
    • Journal Title

      Alcohol Clin. Exp. Res. 31

    • Related Report
      2009 Final Research Report
  • [Presentation] Anti-inflammatory activity of furan fatty acid2009

    • Author(s)
      T. Wakimoto, H. Kondou, K. Tsuji, T. kan
    • Organizer
      The 5th Takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-05-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Anti-inflammatory activity of furan fatty acid2009

    • Author(s)
      脇本敏幸
    • Organizer
      The 5th takeda Science Foundation Symposium on PharmaSciences
    • Place of Presentation
      東京
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 緑イ貝中の抗炎症活性物質の探索2008

    • Author(s)
      脇本敏幸、近藤光、末永聖武、石田均司、辻邦郎、糠谷東雄
    • Organizer
      平成20年度日本水産学会春季大会
    • Place of Presentation
      静岡
    • Year and Date
      2008-03-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 緑イ貝中の抗炎症活性物質の探索2008

    • Author(s)
      脇本 敏幸
    • Organizer
      平成20年度 日本水産学会春季大会
    • Place of Presentation
      静岡
    • Year and Date
      2008-03-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 緑イ貝中の抗炎症活性成分の探索2008

    • Author(s)
      近藤光、脇本敏幸、末永聖武、石田均司、辻邦郎、糠谷東雄
    • Organizer
      日本薬学会年会128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 緑イ貝中の抗炎症活性物質の探索2008

    • Author(s)
      近藤 光
    • Organizer
      第128年会 日本薬学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 緑イ貝中の微量抗酸化性脂質と抗炎症作用について2007

    • Author(s)
      脇本敏幸
    • Organizer
      日本農芸化学会、中部支部第151回例会若手シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2007-11-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 緑イ貝中の微量抗酸化活性脂質と抗炎症作用について2007

    • Author(s)
      脇本 敏幸
    • Organizer
      日本農芸化学会中部支部第151回例会若手シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 緑イ貝中の抗炎症活性物質の探索2007

    • Author(s)
      脇本敏幸
    • Organizer
      第2回化学生態学研究会
    • Place of Presentation
      函館
    • Year and Date
      2007-07-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 緑イ貝中の抗炎症活性物質の探索2007

    • Author(s)
      脇本 敏幸
    • Organizer
      第2回 化学生態学研究会
    • Place of Presentation
      函館
    • Year and Date
      2007-07-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 緑イ貝中の抗炎症活性物質の探索2007

    • Author(s)
      脇本敏幸、末永聖武、石田均司、辻邦 郎、糠谷東雄
    • Organizer
      第21回海洋生物活性談話会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-05-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 緑イ貝中の抗炎症活性物質の探索2007

    • Author(s)
      脇本 敏幸
    • Organizer
      第21回 海洋生物活性談話会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 自己免疫疾患処置剤2007

    • Inventor(s)
      脇本敏幸
    • Industrial Property Rights Holder
      辻邦郎
    • Filing Date
      2007-08-20
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 高脂血症処置剤2007

    • Inventor(s)
      脇本敏幸
    • Industrial Property Rights Holder
      辻邦郎
    • Filing Date
      2007-08-20
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] フラン脂肪酸乃至はその誘導体を含有する皮膚外用剤2007

    • Inventor(s)
      脇本敏幸
    • Industrial Property Rights Holder
      辻邦郎
    • Filing Date
      2007-08-20
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 自己免疫疾患処置剤2007

    • Inventor(s)
      脇本敏幸
    • Industrial Property Rights Holder
      辻 邦郎
    • Filing Date
      2007-08-20
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 高脂血症処置剤2007

    • Inventor(s)
      脇本敏幸
    • Industrial Property Rights Holder
      辻 邦郎
    • Filing Date
      2007-08-20
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] フラン脂肪酸乃至はその誘導体を含有する皮膚外用剤2007

    • Inventor(s)
      脇本敏幸
    • Industrial Property Rights Holder
      辻 邦郎
    • Filing Date
      2007-08-20
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi