A comprehensive computational analysis of antigenic properties of influenza virus hemagglutinin

• Project/Area Number: 19780223
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: IGARASHI Manabu Hokkaido University, 人獣共通感染症リサーチセンター, 博士研究員 (10374240)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,600,000)
• Keywords: 人畜共通感染症 / インフルエンザ / ウイルス / 感染症 / 生体生命情報学 / 分子シミュレーション / 蛋白質 / 糖鎖

Research Abstract

ヒトに馴化したインフルエンザウイルスは、抗原性を毎年少しずつ変化させて、ヒトの免疫機構を巧みに回避し、流行を繰り返す。もし、この変異の過程を予測することが出来れば、インフルエンザを先回りして制御することが出来る。本研究では、計算科学的手法を用いてヒトインフルエンザウイルスの抗原変異に伴う抗原構造の変遷を解析し、将来いずれかのHA 亜型の鳥インフルエンザウイルスがヒトの新型インフルエンザウイルスとして出現した場合の予測方法を検討した。

Research Products

• [Journal Article] Cross-Protective Potential of a Novel Monoclonal Antibody Directed against Antigenic Site B of the Hemagglutininof Influenza A Viruses (2009)
  • Author(s): Reiko Yoshida, Manabu Igarashi, Hiroichi Ozaki, Noriko Kishida, Daisuke Tomabechi, Hiroshi Kida, Kimihito Ito, Ayato Takada
  • Journal Title: PLoS Pathog 5(3)
  • Peer Reviewed
• [Journal Article] バイオインフォマティクスを用いたインフルエンザウイルスヘマグルチニンの糖鎖付加ポテンシャルの予測 (2009)
  • Author(s): 五十嵐学, 伊藤公人, 高田礼人
  • Journal Title: Glycomicrobiology
• [Journal Article] Cross-Protective Potential of a Novel Monoclonal Antibody Directed against Antigenic Site B of the Hernagglutinin of Influenza A Viruses (2009)
  • Author(s): Reiko Yoshida
  • Journal Title: PLoS Pathog 5(3) Pages: 1000350-1000350
  • Peer Reviewed
• [Journal Article] バイオインフォマティクスを用いたインフルエンザウイルスヘマグルチニンの糖鎖付加ポテンシャルの予測 (2009)
  • Author(s): 五十嵐学
  • Journal Title: Glycomicrobiology Jan. 31 Pages: 4-4
• [Journal Article] Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin (2008)
  • Author(s): Manabu Igarashi, Kimihito Ito, Hiroshi Kida, and Ayato Takada
  • Journal Title: Virology 376 Pages: 323-329
  • Peer Reviewed
• [Journal Article] Heterosubtyoic Cross-Neutralization of Influenza A Viruses by a Novel Hemagglutination-Inhibiting Monoclonal Antibody (2008)
  • Author(s): Reiko Yoshida, Manabu Igarashi, Hiroshi Kida, and Ayato Takada
  • Journal Title: Options for the control of influenza VI Pages: 255-256
  • Peer Reviewed
• [Journal Article] Genetically destined potentials for N-linked glycosylation associated with antigenic changes of influenza virus hemagglutinin (2008)
  • Author(s): Manabu Igarashi, Kimihito Ito, Hiroshi Kida, and Ayato Takada
  • Journal Title: Options for the control of influenza VI Pages: 405-407
  • Peer Reviewed
• [Journal Article] Identification of the Molecular DeterminantsRequired for Duck H9N2 Influenza Virus Replication in Chicken (2008)
  • Author(s): Noriko Kishida, Manabu Igarashi, Norikazu Isoda, Kenji Minari, Yoshihiro Sakoda, Hiroshi Kida, and Ayato Takada
  • Journal Title: Options for the control of influenza VI Pages: 549-550
  • Peer Reviewed
• [Journal Article] Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin (2008)
  • Author(s): Manabu Igarashi
  • Journal Title: Virology 376 Pages: 323-329
  • Peer Reviewed
• [Journal Article] Heterosubtyoic Cross-Neutralization of Influenza A Viruses by a Novel Hemagglutination-Inhibiting Monoclonal Antibody (2008)
  • Author(s): Reiko Yoshida
  • Journal Title: Options for the control of influenza VI 1 Pages: 255-256
  • Peer Reviewed
• [Journal Article] Genetically destined potentials for N-linked glycosylation associated with antigenic changes of influenza virus hemagglutinin (2008)
  • Author(s): Manabu Igarashi
  • Journal Title: Options for the control of influenza VI 1 Pages: 405-407
  • Peer Reviewed
• [Journal Article] Identification of the Molecular Determinants Required for Duck H9N2 Influenza Virus Replication in Chickens (2008)
  • Author(s): Noriko Kishida
  • Journal Title: Options for the control of influenza VI 1 Pages: 549-550
  • Peer Reviewed
• [Presentation] インフルエンザウイルスHA遺伝子の塩基配列上に潜在する糖鎖付加ポテンシャルの解析 (2008)
  • Author(s): 五十嵐学, 他
  • Organizer: 第56回日本ウイルス学術集会
  • Place of Presentation: 岡山(岡山コンベンションセンター)
  • Year and Date: 2008-10-26
• [Presentation] Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin (2008)
  • Author(s): Manabu Igarashi, 他
  • Organizer: Taiwan-Japan AI Prevention and Control Conference
  • Place of Presentation: Taiwan(行政院農業委員会家畜衛生試験所)
  • Year and Date: 2008-05-02
• [Presentation] Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin (2008)
  • Author(s): Manabu Igarashi
  • Organizer: Taiwan-Japan AI Prevention and Control Conference
  • Place of Presentation: Taiwan(行政院膿業委員会家畜衛生試験所)
  • Year and Date: 2008-05-02
• [Presentation] 動物インフルエンザのグローバルサーベイランスと全ての亜型ウイルスライブラリーの構築 (2007)
  • Author(s): 梶原将大, 他
  • Organizer: 第55回日本ウイルス学術集会
  • Place of Presentation: 札幌(札幌コンベンションセンター)
  • Year and Date: 2007-10-23
• [Presentation] H5N1 インフルエンザウイルスの電荷依存的なヒト型レセプター認識 (2007)
  • Author(s): 山田晋弥, 他
  • Organizer: 第55回日本ウイルス学術集会
  • Place of Presentation: 札幌(札幌コンベンションセンター)
  • Year and Date: 2007-10-22
• [Presentation] H5N1インフルエンザウイルスの電荷依存的なヒト型レセプター認識 (2007)
  • Author(s): 山田 晋弥
  • Organizer: 第55回日本ウイルス学術集会
  • Place of Presentation: 札幌(札幌コンベンションセンター)
  • Year and Date: 2007-10-22
• [Presentation] アイテム集合間の相関変化検出によるインフルエンザウイルス遺伝子データの解析 (2007)
  • Author(s): 谷口剛, 他
  • Organizer: 第21回人工知能学会全国大会
  • Place of Presentation: 宮崎(ワールドコンベンションセンターサミット)
  • Year and Date: 2007-06-22
• [Presentation] Genetically destined potentials for N-linked glycosylation associated with antigenic changes of influenza virus hemagglutinin (2007)
  • Author(s): Manabu Igarashi, 他
  • Organizer: Options for the Control of Influenza VI
  • Place of Presentation: Canada (Metro Toronto Convention Centre)
  • Year and Date: 2007-06-18
• [Presentation] Heterosubtyoic Cross-Neutralization of Influenza A Virusesby a Novel Hemagglutination-Inhibiting Monoclonal Antibody (2007)
  • Author(s): Reiko Yoshida, 他
  • Organizer: Options for the Control of Influenza VI
  • Place of Presentation: Canada (Metro Toronto Convention Centre)
  • Year and Date: 2007-06-18
• [Presentation] Identification of the Molecular Determinants Required for Duck H9N2 Influenza Virus Replication in Chickens (2007)
  • Author(s): Noriko Kishida, 他
  • Organizer: Options for the Control of Influenza VI
  • Place of Presentation: Canada (Metro Toronto Convention Centre)
  • Year and Date: 2007-06-18
• [Presentation] Genetically destined potentials for N-linked glycosylation associated with antigenic changes of influenza virus hemagglutinin (2007)
  • Author(s): Manabu Igarashi
  • Organizer: Options for the Control of Influenza VI
  • Place of Presentation: Canada(Metro Toronto Convention Centre)
  • Year and Date: 2007-06-18
• [Presentation] Heterosubtyoic Cross-Neutralization of Influenza A Viruses by a Novel Hemagglutination-Inhibiting Monoclonal Antibody (2007)
  • Author(s): Reiko Yoshida
  • Organizer: Options for the Control of Influenza VI
  • Place of Presentation: Canada(Metro Toronto Convention Centre)
  • Year and Date: 2007-06-18
• [Presentation] Identification of the Molecular Determinants Required for Duck H9N2 Influenza Virus Replication in Chickens (2007)
  • Author(s): Noriko Kishida
  • Organizer: Options for the Control of Influenza VI
  • Place of Presentation: Canada(Metro Toronto Convention Centre)
  • Year and Date: 2007-06-18