The defensive mechanisms mediated by Toll-like receptors in canine uterus
| Project/Area Number |
19780233
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KIDA Kayoko Osaka Prefecture University, 生命環境科学研究科, 助教 (50405362)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,540,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Toll-likeレセプター / 感染防御 / イヌ / 子宮 / 発情周期 / イヌ子宮蓄膿症 / 自然免疫 / TLR / defensin / SLPI / 生殖器感染 / TLR4 / TLR2 / IL-8 / 細菌感染 |
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| Research Abstract |
The gene expression of Toll-like receptors (TLRs), that recognize the pathogen-associated molecular patterns (PAMP) and induce immune and inflammatory responses, and their signal pathway molecules were investigated in the canine endometrium. During estrous cycle, they didn't have most changes. However, when the endometrium was stimulated by PAMP, IL-6 and IL-8 mRNA (a kind of inflammatory cytokines) tended to more increase at estrus than at diestrus. It is possible that the immune and inflammatory responses induced by the stimulation of bacterial pathogen may change during the estrous cycle although TLR and their signal pathway molecules gene expression don't change.
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Report
(4 results)
Research Products
(4 results)
