Environmental pollution by new brominated flame retardants

• Project/Area Number: 19780239
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Boundary agriculture
• Research Institution: Ehime University
• Principal Investigator: ISOBE Tomohiko Ehime University, 上級研究員センター, 上級研究員 (50391066)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 環境汚染 / 臭素系難燃剤 / ヘキサブロモシクロドデカン / デトラブロモビスフェノールA / 生物濃縮 / スペシメンバンク / LC-MS / MS / テトラブロモビスフェノールA / LC-MS-MS

Research Abstract

ヘキサブロモシクロドデカン(HBCDs)やテトラブロモビスフェノールA(TBBPA)は使用量が増大している臭素系難燃剤であるが、環境・生態系汚染の実態は全く把握されていない。本研究では、HBCDsとTBBPAの高感度分析法を開発し、汚染の分布や蓄積特性、経時的推移を解析した。その結果、HBCDs汚染はアジア途上国よりも日本沿岸で顕在化していた。保存試料を用いて過去の汚染を復元したところ、HBCDs汚染は近年急激に深刻化していた。

Research Products

• [Journal Article] Organohalogen Contaminants in Striped Dolphins (Stenella coeruleoalba) from Japan : Present Contamination Status, Body Distribution, and Temporal Trends (1978-2003) (2009)
  • Author(s): Isobe, T., Ochi, Y., Ramu, K., Yamamoto, T., Tajima, Y., Yamada, T.K., Amano, M., Miyazaki, N., Takahashi, S., Tanabe, S
  • Journal Title: Marine Pollution Bulletin 58(3) Pages: 396-401
  • Peer Reviewed
• [Journal Article] Organohalogen compounds in human breast milk from mothers living in Payatas and Malate, the Philippines : Levels, accumulation kinetics and infant health risk (2009)
  • Author(s): Malarvannan, G., Kunisue, T., Isobe, T., Sudaryanto, A., Takahashi, S., Prudente, M., Subramanian, A., Tanabe, S
  • Journal Title: Environmental Pollution 157(6) Pages: 1924-1932
  • Peer Reviewed
• [Journal Article] Persistent Organochlorines in Human Breast Milk from Major Metropolitan Cities in India (2009)
  • Author(s): Devanathan, G., Subramanian, A., Someya, M., Sudaryanto, A., Isobe, T., Takahashi, S., Chakraborty, P., Tanabe, S
  • Journal Title: Environmental Pollution 157(1) Pages: 148-154
  • Peer Reviewed
• [Journal Article] Goiter-Like Changes in the Thyroid Gland of Mass Stranded Striped Dolphins (Stenella coeruleoalba) (2009)
  • Author(s): Makara, M., Tajima, Y., Yamada, T.K., Isobe, T., Takahashi, S., Tanabe, S., Shimada, A
  • Journal Title: Journal of Japan Veterinary Medical Association 62(2) Pages: 155-160
  • NAID: 10025575352
  • Peer Reviewed
• [Journal Article] Organohalogen contaminants in striped dolphins (Stenella coeruleoalba) from Japan: Present contamination status, body distribution and temporal trends (1978-2003) (2009)
  • Author(s): Tomohiko Isobe
  • Journal Title: Marine Pollution Bulletin 58 Pages: 396-401
  • Peer Reviewed
• [Journal Article] Organohalogen compounds in human breast milk from mothers living in Payatas and Mslate,_the Philippines: Levels,_accumulation kinetics and infant health risk (2009)
  • Author(s): Govindan Malarvannan
  • Journal Title: Environmental Pollution. 157 Pages: 1924-1932
  • Peer Reviewed
• [Journal Article] Levels and congener specific profiles of PBDEs in human breast milk from China : Implication on exposure sources and pathways (2008)
  • Author(s): Agus, S., Kajiwara, N., Tsydenova, O. V., Isobe, T., Yu, H., Takahashi, S. and Tanabe, S
  • Journal Title: Chemosphere 73(10) Pages: 1661-1668
  • Peer Reviewed
• [Journal Article] Time trends and transplacental transfer of perfluorinated compounds in melon-headed whales stranded along the Japanese coast in 1982, 2000/2001, and 2006 (2008)
  • Author(s): Hart, K., Kannan, K., Isobe, T., Takahashi, S., Yamada, T., Miyazaki, N. and Tanabe, S
  • Journal Title: Environmental Science and Technology 42(19) Pages: 7132-7137
  • Peer Reviewed
• [Journal Article] Spatial trends of polybrominated diphenyl ethers in avian species : Utilization of stored samples in the Environmental Specimen Bank of Ehime University (es-Bank) (2008)
  • Author(s): Kunisue, T., Higaki, Y., Isobe, T., Takahashi, S., Subramanian, An. And Tanabe, S.
  • Journal Title: Environmental Pollution 154(2) Pages: 272-282
  • Peer Reviewed
• [Journal Article] Brominated flame retardants in the environment of Asia-Pacific : an overview of spatial and temporal trends (2008)
  • Author(s): Kunisue, T., Takayanagi, N., Isobe, T., Tanabe, S., Ramu, K., Isobe, T. and Takahashi, S
  • Journal Title: Journal of Environmental Monitoring 10(2) Pages: 188-197
  • Peer Reviewed
• [Journal Article] Levels and body distribution of polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecanes (HBCDs) in freshwater fishes from the Yangtze River, China (2008)
  • Author(s): Xian, Q., Ramu, K., Isobe, T., Sudaryanto, A., Liu, X., Gao, Z., Takahashi, S., Yu, H. and Tanabe, S
  • Journal Title: Chemosphere 71(2) Pages: 268-276
  • Peer Reviewed
• [Journal Article] Regional trend and tissue distribution of brominated flame retardants and persistent organochlorines in raccoon dogs(Nyctereutes procyonoides) from Japan (2008)
  • Author(s): Takahashi, S., Nakatsu, S., Tsubota, T., Okumoto, K., Bushisue, S., Shindo, K. and Tanabe, S
  • Journal Title: Environmental Science & Technology 42(3) Pages: 685-691
  • Peer Reviewed
• [Journal Article] Levels and congener specific profiles of PBDEs in human breast milk from China: Implication on exposure sources and pathways (2008)
  • Author(s): Agus Sudaryanto
  • Journal Title: Chemosphere 73 Pages: 1661-1668
  • Peer Reviewed
• [Journal Article] Spatial trends of polybrominated diphenyl ethers in avian species: Utilization of stored samples in the Environmental Specimen Bank of Ehime University (es-Bank) (2008)
  • Author(s): Tatsuya Kunisue
  • Journal Title: Environmental Pollution 154 Pages: 272-282
  • Peer Reviewed
• [Journal Article] Time trends and transplacental transfer of perfluorinated compounds in melonheaded whales stranded alma the Japanese coast in 1982, 2001/2002, and 2006 (2008)
  • Author(s): Kimberly Hart
  • Journal Title: Environmental Science and Technology 42 Pages: 7132-7137
  • Peer Reviewed
• [Journal Article] Polybrominated Diphenyl Ethers and Hexabromocyclododecanes in Japanese Human Adipose Tissues (2008)
  • Author(s): Tomohiko Isobe
  • Journal Title: Proceedings of Interdisciplinary Studies on Environmental Chemistry-Biological Responses to Chemical Pollutants 73 Pages: 331-338
• [Journal Article] Spatial Distribution and Accumulation of Organohalogen Compounds in Human Breast Milk from the Philippines (2008)
  • Author(s): Govindan Malarvannan
  • Journal Title: Proceedings of Interdisciplinary Studies on Environmental Chemistry-Biological Responses to Chemical Pollutants 73 Pages: 339-347
• [Journal Article] Contamination Status of Brominated Flame Retardants (BFRs) In Baikal Seals (Pusa Sibirica) (2008)
  • Author(s): Tomohiko Isobe
  • Journal Title: Organohalogen Compounds 70 Pages: 1486-1489
  • Peer Reviewed
• [Journal Article] Academic and research programs for capacity development in Asia: Building an environmental chemistry network and its outcomes on persistent organic nollutants and related compounds (2008)
  • Author(s): Shin Takahashi
  • Journal Title: Organohalogen Compounds 73 Pages: 970-973
  • Peer Reviewed
• [Journal Article] Brominated Flame Retardants And Dioxins In Soils From Electronic Waste Recycling Sites In India (2008)
  • Author(s): Karri Rmau
  • Journal Title: Organohalogen Compounds 70 Pages: 2058-2061
  • Peer Reviewed
• [Journal Article] Screening Of Organohalogen Compounds Accumulated In Marine Mammals By Using GC-HRTOFMS (2008)
  • Author(s): Hidenori Matsukami
  • Journal Title: Organohalogen Compounds 70 Pages: 46-49
  • Peer Reviewed
• [Journal Article] Brominated Flame Retardants And Persistent Organic Pollutants In Indonesia: Assessment Of Human Exposure (2008)
  • Author(s): Agus Sudaryanto
  • Journal Title: Organohalogen Compounds 70 Pages: 2236-2239
  • Peer Reviewed
• [Journal Article] Assessment of brominated flame retardants in sediments from Asia : levels, profiles and temporal trends (2007)
  • Author(s): Sudaryanto, A., Ramu, K., Isobe, T., Minh, N. H., Agusa, T., Kajiwara, N., Takahashi, S., Iwata, H., Setiawan, I. E., Ilyas, M., Ismail, A., Min, B. Y., Matsumoto, K. and Tanabe, S
  • Journal Title: Organohalogen Compounds 69 Pages: 2744-2747
  • Peer Reviewed
• [Journal Article] Brominated flame retardants in raccoon dogs from Japan - a monitoring survey of wild terrestrial mammals (2007)
  • Author(s): Isobe, T., Takayanagi, N., Kunisue, T., Nakatsu, S., Tsubota, T., Okumoto, K., Bushisue, S., Shindo, K., Takahashi, S. and Tanabe, S
  • Journal Title: Organohalogen Compounds 69 Pages: 2732-2735
  • Peer Reviewed
• [Journal Article] Levels and temporal trends of brominated flame retardants (PBDEs and HBCDs) in Asian waters using archived samples from es-BANK, Ehime University, Japan (2007)
  • Author(s): Tanabe, S., Ramu, K., Isobe, T., Kajiwara, N., Takahashi, S., Jefferson, T. A. and Yamada, T. K
  • Journal Title: Organohalogen Compounds 69 Pages: 500-503
  • Peer Reviewed
• [Journal Article] Organohalogen compounds in deep sea organisms from East China Sea : levels, profiles, and fate (2007)
  • Author(s): Ramu, K., Kajiwara, N., Isobe, T., Takahashi, S., Miyasaka, H., Kubodera, T. and Tanabe, S
  • Journal Title: Organohalogen Compounds 69 Pages: 437-440
  • Peer Reviewed
• [Journal Article] Levels and distribution of organochlorine compounds and brominated flame retardants in fish from Laos (2007)
  • Author(s): Sudaryanto, A., Isobe, T., Agusa, T., Takahashi, S., Iwata, H., Nakamura, S., Takizawa, S. and Tanabe, S
  • Journal Title: Organohalogen Compounds 69 Pages: 55-58
  • Peer Reviewed
• [Journal Article] Polybrominated diphenyl ethers and persistent organochlorines in Japanese human adipose tissues (2007)
  • Author(s): Kunisue, T., Takayanagi, N., Isobe, T., Takahashi, S., Nose, M., Yamada, T., Komori, H., Arita, N., Ueda, N. and Tanabe, S
  • Journal Title: Environment International 33(8) Pages: 1048-1056
  • Peer Reviewed
• [Journal Article] Isomer specific determination of hexabromocyclododecanes (HBCDs) in small cetaceans from the South China Sea ? Levels and temporal variation (2007)
  • Author(s): Isobe, T., Ramu, K., Kajiwara, N., Takahashi, S., Lam, P. K. S., Jefferson, T. A., Zhou, K. and Tanabe, S
  • Journal Title: Marine Pollution Bulletin 54(8) Pages: 1139-1145
  • Peer Reviewed
• [Journal Article] Brominated flame retardants in raccoon dogs from Japan - a monitoring survey of wild terrestrial mammals. (2007)
  • Author(s): Isobe, T.
  • Journal Title: Organohalogen Compounds 69 Pages: 2732-2735
  • Peer Reviewed
• [Journal Article] Polybrominated diphenyl ethers and persistent organochlorines in Japanese human adipose tissues. (2007)
  • Author(s): Kunisue, T.
  • Journal Title: Environment International 33 Pages: 1048-1056
  • Peer Reviewed
• [Journal Article] Regional trend and tissue distribution of brominated flame retardants and persistent organochlorines in raccoon dogs(Nyctereutes procyonoides)from Japan. (2007)
  • Author(s): Kunisue, T.
  • Journal Title: Environmental Science & Technology 42 Pages: 685-691
  • Peer Reviewed
• [Presentation] Contamination status of brominated flame retardants (BFRs) in Baikal seals (Pusas sibirica). Interdisciplinary Symposium on Environmental Sciences (2008)
  • Author(s): Isobe, T., Ochi, Y., Imaeda, D., Sakai, H., Hirakawa, S., Tsydenova, O., Amano, M., Petrov, E., Batoev, V., Iwata, H., Takahashi, S. and Tanabe, S
  • Organizer: To Establish an Asian Network of Environmental Researchers
  • Place of Presentation: Matsuyama, Japan
• [Presentation] Contamination status of brominated flame retardants (BFRs) in Baikal seals (Pusa sibirica) (2008)
  • Author(s): Isobe, T., Ochi, Y., Imaeda, D., Sakai, H., Hirakawa, S., Tsydenova, O., Amano, M., Petrov, E., Batoev, V., Iwata, H., Takahashi, S. and Tanabe, S
  • Organizer: 28th International Symposium on Halogenated Persistent Organic Pollutants (POPs)
  • Place of Presentation: Birmingham, United Kingdom
• [Presentation] Accumulation of polybrominated diphenyl ethers and hexabromocyclododecanes in mesenteric adipose tissue of Japanese (2008)
  • Author(s): Isobe, T., Oda, H., Takayanagi, N., Kunisue, T., Nose, M., Yamada, T., Komori, K., Takahashi, S. and Tanabe, S
  • Organizer: 5th SETAC World Congress
  • Place of Presentation: Sydney, Australia
• [Presentation] Contamination by brominated flame retardants in some wild and pet terrestrial mammals from Japan (2008)
  • Author(s): Isobe, T., Kunisue, T., Takayanagi, N., Nakatsu, S., Tsubota, T., Asakawa, M., Takahashi, S. and Tanabe, S
  • Organizer: 5th SETAC World Congress, Sydney
  • Place of Presentation: Australia
• [Presentation] 愛媛県興居島に座礁したスジイルカ(Stenella coeruleoalba)の有機ハロゲン化合物汚染の実態と過去復元 (2008)
  • Author(s): 磯部友彦・越智陽子・山本貴仁・高橋真・田辺信介
  • Organizer: 日本セトロジー研究会第19回(金沢)大会
  • Place of Presentation: 金沢市
• [Presentation] 日本国内の小型陸棲哺乳類における臭素系難燃剤汚染 (2008)
  • Author(s): 磯部友彦・国末達也・高柳望・中津賞・坪田敏男・浅川満彦・奥本啓祐・武士末純夫・進藤三幸・高橋真・田辺信介
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸市
• [Presentation] ヒト脂肪組織中のヘキサブロモシクロドデカン (2008)
  • Author(s): 磯部友彦・小田裕子・高柳望・国末達也・能勢真人・山田健人・小森浩章・有田典正・上田規史・高橋真・田辺信介
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸市
• [Presentation] Polybrominated diphenyl ethers and hexabromocyclododecanes in Japanese human adipose tissues (2008)
  • Author(s): Isobe, T., Oda, H., Takayanagi, N., Kunisue, T., Nose, M., Yamada, T., Komori, H., Arita, N., Ueda, N., Takahashi, S. and Tanabe, S.
  • Organizer: International Symposium on Biological responses to Chemical Pollutants : Toward Establishing an Asian Network of Environmental Toxicology
  • Place of Presentation: Matsuyama, Japan
• [Presentation] 安定同位体比を用いた相模湾深海生態系の解析と臭素系難燃剤の蓄積特性 (2008)
  • Author(s): 豊島沙織
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸市
• [Presentation] GC-HRTOFMSによる海棲哺乳類中に蓄積した有機ハロゲン化合物の検索 (2008)
  • Author(s): 松神秀徳
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸市
• [Presentation] 臭素系難燃剤(BFR)によるアジア途上国都市ゴミ集積場の土壌汚染 (2008)
  • Author(s): 江口哲史
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸市
• [Presentation] Distribution of brominated flame retardants in sediments and their bioaccumulation in biota from Jakarta Bay, Indonesia (2008)
  • Author(s): Agus Sudaryanto
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸市
• [Presentation] Levels and patterns of brominated flame retardants in soils from electronic waste recycling sites in India (2008)
  • Author(s): Karri Ramu
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸市
• [Presentation] Contamination status of organochlorine pollutants in human milk from Vietnamese e-waste recycling sites (2008)
  • Author(s): Nguyen Minh Tue
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸市
• [Presentation] 有機ハロゲン化合物による東北沖深海生物の汚染実態の解明 (2008)
  • Author(s): 忍穂井智子
  • Organizer: 第17回環境化学討論会
  • Place of Presentation: 神戸市
• [Presentation] 愛媛県興居島に座礁したスジイルカ(Stenellla coeruleoalba)の有機ハロゲシ化合物汚染の実態と過去復元 (2008)
  • Author(s): 磯部友彦
  • Organizer: 日本セトロジー研究会第19回
  • Place of Presentation: 金沢市
• [Presentation] Contamination by brominated flame retardants in some wild and pet terrestrial mammals from Japan (2008)
  • Author(s): Tomohiko Isobe
  • Organizer: 5^<th> SETAC World Congress
  • Place of Presentation: Sydney, Australia
• [Presentation] Contamination status of brominated flame retardants (BFRs) in Baikal seals (Pusa sibirica) (2008)
  • Author(s): Tomohiko Isobe
  • Organizer: 28^<th> International Symposium on Halogenated Persistent Organic Pollutants (POPs)
  • Place of Presentation: Birmingham, UK
• [Presentation] Polybrominated diphenyl ethers and hexabromocyclododecanes in Japanese human adipose tissues. (2008)
  • Author(s): Isobe, T.
  • Organizer: International Symposium on Biological responses to Chemical Pollutants
  • Place of Presentation: Matsuyama, Japan
• [Presentation] Brominated flame retardants in raccoon dogs from Japan ? a monitoring survey of wild terrestrial mammals (2007)
  • Author(s): Isobe, T., Takayanagi, N., Kunisue, T., Nakatsu, S., Tsubota, T., Okumoto, K., Bushisue, S., Shindo, K., Takahashi, S. and Tanabe, S
  • Organizer: DIOXIN 2007 International Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] 有機塩素化合物および臭素系難燃剤によるスジイルカの汚染実態と蓄積特性 (2007)
  • Author(s): 磯部友彦・越智陽子・Ramu, K.・山本貴仁・高橋真・田辺信介
  • Organizer: 第16回環境化学討論会
  • Place of Presentation: 北九州市
• [Presentation] Contamination Status and Body Distribution of Organohalogen Compounds in Striped Dolphins (Stenella Coeruleoalba) Stranded at Gogo-shima Island, Matsuyama, Japan (2007)
  • Author(s): Isobe, T., Ochi, Y., Ramu. K., Yamamoto, T., Takahashi, S., Tanabe, S
  • Organizer: 4th International Workshop on Brominated Flame Retardants
  • Place of Presentation: Amsterdam, The Netherlands
• [Presentation] Contamination Status and Body Distribution of Organohalogen Compounds in Striped Dolphins(Stenella Coeruleoalba) Stranded at Gogo-shima Island, Matsuyama, Japan (2007)
  • Author(s): Isobe, T.
  • Organizer: 4th International Workshop on Brominated Flame Retardants
  • Place of Presentation: Amsterdam, The Netherlands
• [Presentation] Brominated flame retardants in raccoon dogs from Japan - a monitoring survey of wild terrstrial mammals. (2007)
  • Author(s): Isobe, T.
  • Organizer: DIOXIN 2007 International Symposium
  • Place of Presentation: Tokyo, Japan
• [Book] 分子で読む環境汚染 (2009)
  • Author(s): 鈴木聡編著
  • Publisher: 東海大学出版会