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Design and synthesis of non-proteinogenic amino acids and peptide foldamers by anodic functionalizaton

Research Project

Project/Area Number 19790017
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionNational Institute of Health Sciences (2008)
Nagasaki University (2007)

Principal Investigator

DEMIZU Yosuke  National Institute of Health Sciences, 有機化学部, 研究官 (90389180)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords非天然型アミノ酸 / ペプチド / 電極酸化 / フォールダマー / N-オキシル / 電極反応 / 酸化反応 / 環状アミン
Research Abstract

新たな構造特性と機能を併せ持つ新規な人工タンパク質の創製には、天然に存在しない人工アミノ酸を用いることが有用である。本研究では人工アミノ酸の効率的合成とその利用を目的とし研究遂行した。その結果、入手容易な天然アミノ酸から有機化学的手法と電気化学的手法を駆使したハイブリット手法により、人工アミノ酸の効率的合成に成功した。また、合成したアミノ酸とその誘導体は、酸化触媒として機能することを明らかとした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (70 results)

All 2008 2007 Other

All Journal Article (36 results) (of which Peer Reviewed: 36 results) Presentation (9 results) Remarks (1 results) Patent(Industrial Property Rights) (24 results) (of which Overseas: 1 results)

  • [Journal Article] Convenient synthesis of enantiomerically enriched bicyclic proline and the corresponding N-oxyls2008

    • Author(s)
      Y. Demizu, H. Shiigi, H. Mori, K. Matsumoto, O. Onomura
    • Journal Title

      Tetrahedron: Asymmetry 19

      Pages: 2659-2665

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effecient kinetic resolution of racemic-aminoaldehydes by oxidation with NIS2008

    • Author(s)
      D. Minato, Y. Nagasue, Y. Demizu, O. Onomura
    • Journal Title

      Angew. Chem. Int. Ed 47

      Pages: 9458-9461

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative C-C bond cleavage of N-alkoxycarbonylated cyclic amines by sodium nitrite in trifluoroacetic acid2008

    • Author(s)
      O. Onomura, A. Moriyama, K. Fukae, Y. Yamamoto, T. Maki, Y. Matsumura, Y. Demizu
    • Journal Title

      Tetrahedron Lett 49

      Pages: 6728-6731

    • NAID

      120006982372

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regioselective protection of sugars catalyzed by dimethyltin dichloride2008

    • Author(s)
      Y. Demizu, Y. Kubo, H. Miyoshi, T. Maki, Y. Matsumura, N. Moriyama, O. Onomura
    • Journal Title

      Org. Lett 10

      Pages: 5075-5077

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regioselective introduction of electrophiles into piperidine derivatives at the 4-position2008

    • Author(s)
      O. Onomura, N. Fujimura, T. Oda, Y. Matsumura, Y. Demizu
    • Journal Title

      Heterocycles 76

      Pages: 177-182

    • NAID

      120006984129

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chiral azabicyclo-N-oxyls mediated enantioselective electrooxidation of sec-alcohols2008

    • Author(s)
      H. Shiigi, H.Mori, T. Tanaka, Y. Demizu, O. Onomura
    • Journal Title

      Tetrahedron Lett 49

      Pages: 5247-5251

    • NAID

      120006981658

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diastereoselective arylation of L-proline derivatives at the 5-position2008

    • Author(s)
      O. Onomura, P. G. Kirira, T. Tanaka, S. Tsukada, Y. Matsumura, Y. Demizu
    • Journal Title

      Tetrahedron 64

      Pages: 7498-7503

    • NAID

      120006981712

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric electrochemical oxidation of 1,2-diols, aminoalcohols and aminoaldehydes in the presenceof chiral copper catalyst2008

    • Author(s)
      D. Minato, H. Arimoto, Y. Nagasue, Y. Demizu, O. Onomura
    • Journal Title

      Tetrahedron 64

      Pages: 6675-6683

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High regioselective in electrochemical α-methoxylation of N-protected cyclic amines2008

    • Author(s)
      S. S. Libendi, Y. Demizu, Y. Matsumura, O. Onomura
    • Journal Title

      Tetrahedron 64

      Pages: 3935-3942

    • NAID

      120006981389

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst2008

    • Author(s)
      Y. Demizu, Y. Kubo, Y. Matsumura, O. Onomura
    • Journal Title

      Synlett

      Pages: 433-437

    • NAID

      120006982422

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls2008

    • Author(s)
      Y. Demizu, H. Shiigi, T. Oda, Y. Matsumura, O. Onomura
    • Journal Title

      Tetrahedron Lett 49

      Pages: 48-52

    • NAID

      120006981360

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computational study on secondary structure of oligopeptides containing α,α-disubstituted α-amino acids2008

    • Author(s)
      M. Kurihara, Y. Sato, F. Kaneko, H. Okuda, M. Nagano, Y. Demizu, M. Doi, M. Tanaka, H. Suemune
    • Journal Title

      Peptide Science 2007

      Pages: 137-138

    • NAID

      10021906747

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls2008

    • Author(s)
      Demizu, Y. et al.
    • Journal Title

      Tetrahedron Letters 49

      Pages: 48-52

    • NAID

      120006981360

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst2008

    • Author(s)
      Demizu, Y. et al.
    • Journal Title

      Synlett

      Pages: 433-437

    • NAID

      120006982422

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High regioselective in electrochemical α-methoxylation of N-protected cyclic amines2008

    • Author(s)
      Samuel, S. S. et al.
    • Journal Title

      Tetrahedron 64

      Pages: 3935-3942

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric electrochemical oxidation of 1,2-diols, aminoalcohols and aminoaldehydes in the presence of chiral copper catalyst2008

    • Author(s)
      Minato, D. et al.
    • Journal Title

      Tetrahedron 64

      Pages: 6675-6683

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diastereoselective arylation of L-proline derivatives at the 5-position2008

    • Author(s)
      Onomura, O. et al.
    • Journal Title

      Tetrahedron 64

      Pages: 7498-7503

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chiral azabicyclo-N-oxyls mediated enantioselective electrooxidation of sec-alcohols2008

    • Author(s)
      Shiigi, H. et al.
    • Journal Title

      Tetrahedron Letters 49

      Pages: 5247-5251

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regioselective introduction of electrophiles into piperidine derivatives at the 4-position2008

    • Author(s)
      Onomura, O. et al.
    • Journal Title

      Heterocycles 76

      Pages: 177-182

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regioselective protection of sugars catalyzed by dimethyltin dichloride2008

    • Author(s)
      Demizu, Y. et al.
    • Journal Title

      Organic Letters 10

      Pages: 5075-5077

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative C-C bond cleavage of N-alkoxycarbonylated cyclic amines by sodium nitrite in trifluoroacetic acid2008

    • Author(s)
      Onomura, O. et al.
    • Journal Title

      Tetrahedron Letters 49

      Pages: 6728-6731

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effecient kinetic resolution of racemric-aminoaldehydes by oxidation with NIS2008

    • Author(s)
      Minato, D. et al.
    • Journal Title

      Angew. Chem. Int. Ed. 47

      Pages: 9458-9461

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convenient synthesis of enantiomerically enriched bicyclic proline and the corresponding N-oxyls2008

    • Author(s)
      Demizu, Y. et al.
    • Journal Title

      Tetrahedron : Asymmetry 19

      Pages: 2659-2665

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls2008

    • Author(s)
      Demizu, Y., et. al.
    • Journal Title

      Tetrahedron Letters 49

      Pages: 48-52

    • NAID

      120006981360

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst2008

    • Author(s)
      Demizu, Y., et. al.
    • Journal Title

      Synlett 3

      Pages: 433-437

    • NAID

      120006982422

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric tosylation of racemic 2-hydroxyalkanamides with chiral copper catalyst2007

    • Author(s)
      O. Onomura, M. Mitsuda, T. T. M. Nguyen, Y. Demizu
    • Journal Title

      Tetrahedron Lett 48

      Pages: 9080-9084

    • NAID

      120006981361

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric oxidation of 1,2-diols using N-bromosuccinimide in the presence of chiral copper catalyst2007

    • Author(s)
      O. Onomura, H. Arimoto, Y. Matsumura, Y. Demizu
    • Journal Title

      Tetrahedron Lett 48

      Pages: 8668-8672

    • NAID

      120006981362

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Copper complex catalyzed asymmetric monosulfonylation of meso-vic-diols2007

    • Author(s)
      Y. Demizu, K. Matsumoto, O. Onomura, Y. Matsumura
    • Journal Title

      Tetrahedron Lett 48

      Pages: 7605-7609

    • NAID

      120006981364

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipase-catalyzed kinetic resolution of cyclic trans-1,2-diols bearing a diester moiety: Synthetic application to chiral seven-membered ring α,α-disubstituted α-amino acid2007

    • Author(s)
      M. Tanaka, Y. Demizu, M. Nagano, M. Hama, Y. Yoshida, M. Kurihara, H. Suemune
    • Journal Title

      J. Org. Chem 72

      Pages: 7750-7756

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCM2007

    • Author(s)
      T. Maruyama, Y. Demizu, S. Kozai, M. Witvrouw, C. Pannecouque, P. J. Balzarini, R. Snoecks, G. Andrei, E. De Clercq
    • Journal Title

      Nucleosides, Nucleotides & Nucleic Acids 26

      Pages: 1553-1558

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Controlling 310-helix and α-helix of short peptides in the solid state2007

    • Author(s)
      Y. Demizu, M. Tanaka, M. Nagano, M. Kurihara, M. Doi, T. Maruyama, H. Suemune
    • Journal Title

      Chem. Pharm. Bull 55

      Pages: 840-842

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 1,2-ジオール分子認識に基づく選択的分子変換反応2007

    • Author(s)
      松村功啓、尾野村治、出水庸介
    • Journal Title

      有機合成化学協会誌 第65巻

      Pages: 46-55

    • NAID

      10018578272

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Computational study on conformation of oligopeptides containing chiral cyclic α,α-disubstituted a-amino acids2007

    • Author(s)
      M. Kurihara, Y. Sato, W. Hakamata, H. Okuda, Y. Demizu, M. Nagano, N. Kawabe, M. Doi, M. Tanaka, H. Suemune
    • Journal Title

      Peptides 2006

      Pages: 546-547

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Side-chain chiral centers of amino acids and helical-screw handedness of their peptides2007

    • Author(s)
      M. Tanaka, M. Nagano, Y. Demizu, K. Anan, M. Kurihara, M. Doi, H. Suemune
    • Journal Title

      Peptides 2006

      Pages: 268-269

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secondary structure of heteropeptides using chiral cyclic α,α-disubstituted amino acids2007

    • Author(s)
      M. Nagano, M. Tanaka, Y. Demizu, M. Kurihara, M. Doi, H. Suemune
    • Journal Title

      Peptides 2006

      Pages: 476-477

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric tosylation of racemic 2-hydroxyalkanamides with chiral copper catalyst2007

    • Author(s)
      Onomura, O., et. al.
    • Journal Title

      Tetrahedron Letters 48

      Pages: 9080-9084

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chiral azabicyclo-N-oxyls and asymmetric oxidation of secondary alcohols mediated by them2008

    • Author(s)
      Demizu, Y.; Shiigi, H.; Mori, H.; Matsumoto, K.; Matsumura, Y.; Onomura, O
    • Organizer
      213th ECS Meeting
    • Place of Presentation
      Phoenix
    • Related Report
      2008 Final Research Report
  • [Presentation] 分子認識に基づくアルコール類の不斉トシル化2008

    • Author(s)
      出水庸介, ,満田勝, 松本和也, 松村功啓, 尾野村治
    • Organizer
      日本薬学会第128年会
    • Related Report
      2008 Final Research Report
  • [Presentation] Chiral azabicyclo-N-oxyls and asymmetric oxidation of secondary alcohols mediated by them2008

    • Author(s)
      Demizu, Y. et al.
    • Organizer
      The 213th ECS Meeting
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規キラルN-オキシルを用いる二級アルコールの不斉電極酸化2007

    • Author(s)
      出水庸介
    • Organizer
      第31回有機電子移動化学討論会
    • Place of Presentation
      鳥取
    • Year and Date
      2007-06-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Electrochemical oxidation of alcohols catalyzed by new organic mediators2007

    • Author(s)
      Demizu, Y.
    • Organizer
      211th ECS Meeting
    • Place of Presentation
      アメリカ
    • Year and Date
      2007-05-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 分子認識に基づくアルコール類の不斉トシル化2007

    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2007-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 分子認識に基づくキラル銅触媒を用いたアルコール類の不斉トシル化2007

    • Author(s)
      出水庸介
    • Organizer
      第1回若手交流合宿セミナー
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 新規キラルN-オキシンを用いる二級アルコールの不斉電極酸化2007

    • Author(s)
      出水庸介, 末続肇, 尾野村治, 松村功啓
    • Organizer
      第31回有機電子移動化学討論会
    • Place of Presentation
      鳥取
    • Related Report
      2008 Final Research Report
  • [Presentation] Electrochemical oxidation of alcohols catalyzed by new organic mediators2007

    • Author(s)
      Demizu, Y.; Oda, T.; Onomura, O.; Matsumura, Y
    • Organizer
      211th ECS Meeting
    • Place of Presentation
      Chicago
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.nihs.go.jp/doc/2shitu.html

    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 光学活性α-アシルオキシリン酸誘導体の製造方法2008

    • Inventor(s)
      尾野村冶, 出水庸介, 森山敦, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 森山敦, 岩崎史哲
    • Industrial Property Number
      2008-286370
    • Filing Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] ラムノシドエステル誘導体およびその製造方法2008

    • Inventor(s)
      尾野村冶, 出水庸介, 久保裕紀, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 久保裕紀, 岩崎史哲
    • Industrial Property Number
      2008-192243
    • Filing Date
      2008-07-25
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] キシロシドエステル誘導体およびその製造方法2008

    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-075320
    • Filing Date
      2008-03-24
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 光学活性アミノ酸エステル誘導体、及び光学活性アミノアセタール誘導体の製造方法2008

    • Inventor(s)
      尾野村冶, 出水庸介, 山本博将
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 山本博将
    • Industrial Property Number
      2008-072911
    • Filing Date
      2008-03-21
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] グルコシドエステル誘導体およびその製造方法2008

    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-068124
    • Filing Date
      2008-03-17
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] ピラノシドジエステル化合物及びその製造方法2008

    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-057503
    • Filing Date
      2008-03-07
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 含窒素レドックス触媒2008

    • Inventor(s)
      松村功啓, 尾野村冶, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村冶, 出水庸介
    • Filing Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 脂肪族ジカルボン酸化合物の製造方法2008

    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-025594
    • Filing Date
      2008-02-05
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 光学活性モノスルホネート化合物の製造方法2008

    • Inventor(s)
      松村功啓, 尾野村冶, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村冶, 出水庸介
    • Patent Publication Number
      2008-290981
    • Acquisition Date
      2008-12-04
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] α、α-ジ置換環状含窒素化合物の製造方法2008

    • Inventor(s)
      松村功啓, 尾野村冶, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村冶, 出水庸介
    • Patent Publication Number
      2008-240106
    • Acquisition Date
      2008-10-09
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 光学活性ビスオキサゾリン-銅錯体を不斉触媒おするN-保護アミノアルコール化合物の不斉エステル化反応2008

    • Inventor(s)
      松村功啓, 尾野村冶, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村冶, 出水庸介
    • Patent Publication Number
      2008-037865
    • Acquisition Date
      2008-02-21
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 脂肪族ジカルボン酸化合物の製造方法2008

    • Inventor(s)
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-025594
    • Filing Date
      2008-02-05
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 含窒素レドックス触媒2008

    • Inventor(s)
      松村功啓, 尾野村治, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村治, 出水庸介
    • Filing Date
      2008-03-28
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ピラノシドジエステル化合物及びその製造方法2008

    • Inventor(s)
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-057503
    • Filing Date
      2008-03-07
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] グルコシドエステル誘導体およびその製造方法2008

    • Inventor(s)
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-068124
    • Filing Date
      2008-03-17
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 光学活性アミノ酸エステル誘導体、及び光学活性アミノアセタール誘導体の製造方法2008

    • Inventor(s)
      尾野村治, 出水庸介, 山本博将
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 山本博将
    • Industrial Property Number
      2008-072911
    • Filing Date
      2008-03-21
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] キシロシドエステル誘導体およびその製造方法2008

    • Inventor(s)
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-075320
    • Filing Date
      2008-03-24
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] ラムノシドエステル誘導体およびその製造方法2008

    • Inventor(s)
      尾野村治, 出水庸介, 久保裕紀, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 久保裕紀, 岩崎史哲
    • Industrial Property Number
      2008-192243
    • Filing Date
      2008-07-25
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 光学活性α-アシルオキシリン酸誘導体の製造方法2008

    • Inventor(s)
      尾野村治, 出水庸介, 森山敦, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 森山敦, 岩崎史哲
    • Industrial Property Number
      2008-286370
    • Filing Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 光学活性モノスルホネート化合物の製造方法2008

    • Inventor(s)
      松村功啓, 尾野村治, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村治, 出水庸介
    • Patent Publication Number
      2008-290981
    • Acquisition Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] α, α-ジ置換環状含窒素化合物の製造方法2008

    • Inventor(s)
      松村功啓, 尾野村治, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村治, 出水庸介
    • Patent Publication Number
      2008-240106
    • Acquisition Date
      2008-10-09
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 光学活性ビスオキサゾリン-銅錯体を不斉触媒とするN-保護アミノアルコール化合物の不斉エステル化反応2008

    • Inventor(s)
      松村功啓, 尾野村治, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村治, 出水庸介
    • Patent Publication Number
      2008-037865
    • Acquisition Date
      2008-02-21
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 光学活性α-スルホニルオキシカルボン酸アミド誘導体及びそれらの製造方法2007

    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2007-265700
    • Filing Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 光学活性α-スルホニルオキシカルボン酸アミド誘導体及びそれらの製造方法2007

    • Inventor(s)
      尾野村治、出水庸介、岩崎史哲
    • Industrial Property Rights Holder
      尾野村治、出水庸介、岩崎史哲
    • Industrial Property Number
      2007-265700
    • Filing Date
      2007-10-11
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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