Asymmetric synthetic studies on jiadifenin, neurotrophic compound
| Project/Area Number |
19790027
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
HARADA Kenichi Tokushima Bunri University, 薬学部, 助教 (70441590)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,710,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 合成化学 / 有機合成化学 / ジアジフェニン / 神経栄養因子 / アルツハイマー病 / 神経突起伸展促進活性 / パラジウム触媒 / Tsuji-Trost反応 / 構造活性相関 / 神経突起伸展促進 / パラシウム触媒 / イリジウム触媒 / Mizoroki-Heck反応 |
|---|
| Research Abstract |
An efficient synthetic route for neurotrophic jiadifenin has been established. The key steps were Pd-catalyzed Mizoroki-Heck reaction for cyclopentene ring and successive Tsuji-Trost reaction and lactonization for center and lactone rings.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXR-agonists2009
Author(s)
H. Hioki, N. shima, K. Kawaguchi, K. Harada, M. Kubo, T. Esumi, T. Nishimaki-Mogami, J. Sawada, T. Hashimoto, Y. Asakawa, Y. Fukyama
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Journal Title
Bioorg. Med. Chem. Lett. 19
Pages: 738-741
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[Journal Article] Synthesis of (-)-talaumidin, a neurotrophic 2, 5-biaryl-3, 4-dimethyltetrahydrofuran lignan, and its stereoisomers2008
Author(s)
Y. Fukuyama, K. Harada, T. Esumi, D. Hojyo, Y. Kujime, N. Kubo, M. Kubo, H. Hioki
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Journal Title
Heterocycles. 76
Pages: 551-567
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