Development of an efficient and precise separation method for nano materials

• Project/Area Number: 19790031
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Physical pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: KATO Masaru The University of Tokyo, 大学院・薬学系研究科, 特任准教授 (30332943)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 分離科学 / ナノ物質 / ナノバイオ / 電気泳動 / クロマトグラフィー / βアミロイド / ナノカーボン / アルツハイマー病 / カーボンナノチューブ / 分離分析 / ラマン分光 / プローブ顕微鏡 / 創薬 / 分散

Research Abstract

ナノテクノロジーの進展により、優れたナノ物質が開発され注目を集めているが、高効率な分離精製法は報告されていなかった。我々は、カーボンナノチューブ(CNT)やアミロイドβなどのナノ物質の高精度な分離法を開発し、さらに分離したナノ物質1個の構造決定に成功した。分析法の開発と共に、溶媒に分散しないため分離することが難しいCNTを溶液や乾固した状態で安定に孤立分散させる方法を開発した。

Research Products

• [Journal Article] Streaming potential/current measurement system for investigation of liguid confined in extended-nano space. (2010)
  • Author(s): Kyojiro Morikawa, Kazuma Mawatari, Masaru Kato, Takehiko Tsukahara, Takehiko Kitamori
  • Journal Title: Lab Chip 10 Pages: 871-875
  • Peer Reviewed
• [Journal Article] Femto Liquid Chromatography with Atto-Liter Sample Separation in the Extended Nanospace Channel. (2010)
  • Author(s): Masaru Kato, Masanori Inaba, Takehiko Tsukahara, Kazuma Mawatari, Akihide Hibara, Takehiko Kitamori
  • Journal Title: Anal. Chem. 82 Pages: 543-547
  • Peer Reviewed
• [Journal Article] An Analytical System for Single Nanomaterials: Hyphenation of Capillary Electrophoresis with Raman Spectrometry or with Scanning Probe Microscopy for Individual Single-Walled Carbon Nanotube Analysis. (2009)
  • Author(s): Tatsuhiro Yamamoto, Yoichi Murakami, Jin Motoyanagi, Takanori Fukushima, Shigeo Maruyama, Masaru Kato
  • Journal Title: Anal. Chem. 81 Pages: 7336-7341
  • Peer Reviewed
• [Journal Article] Surfactant- Stabilized Single-Walled Carbon Nanotubes Using Triphenylene Derivatives Remain Individually Dispersion in Both Liquid and Dried Solid States. (2009)
  • Author(s): Tatsuhiro Yamamoto, Jin Motoyanagi, Yoichi Murakami, Yuhei Miyauchi, Shigeo Maruyama, Masaru Kato
  • Journal Title: Applied Physics Express 2 Pages: 55501-55501
  • NAID: 10025086237
  • Peer Reviewed
• [Journal Article] Development of a silica-based double network hydrogel for high-throughput screening of encapsulated enzymes. (2009)
  • Author(s): Masaru Kato, Naomi Shoda, Tatsuhiro Yamamoto, Reiko Shiratori, Toshimasa Toyo'oka
  • Journal Title: Analyst 134 Pages: 577-581
  • Peer Reviewed
• [Journal Article] An Analytical System for Single Nanomaterials : Hyphenation of Capillary Electrophoresis with Raman Spectrometry or with Scanning Probe Microscopy for Individual Single-Walled Carbon Nanotube Analysis (2009)
  • Author(s): T.Yamamoto, Y.Murakami, J.Motoyanagi, S.Maruyama, T.Fukushima, M.Kato
  • Journal Title: Analytical Chemistry 81 Pages: 7336-7341
  • Peer Reviewed
• [Journal Article] Improved bath sonication method for dispersion of individual single-walled carbon nanotubes using new triphenylene-based surfactant. (2008)
  • Author(s): Tatsuhiro Yamamoto, Yuhei Miyauchi, Jin Motoyanagi, Takanori Fukushima, Takuzo Aida, Masaru Kato, Shigeo Maruyama
  • Journal Title: Jap. J. Appl. Phys. 47 Pages: 2000-2004
  • Peer Reviewed
• [Journal Article] Improved bath sonication method for dispersion of individual single-walled carbon nanotubes using new triphenylene-based surfactant (2008)
  • Author(s): T. Yamamoto, Y. Miyauchi, J. Motoyanagi, T. Fukushima, T. Aida, M. Kato, S. Maruyama
  • Journal Title: Jap. J. Appl. Phys. 47 Pages: 2000-2004
  • Peer Reviewed
• [Journal Article] キャピラリー電気泳動を用いたアミロイド重合体の分離 (2008)
  • Author(s): 加藤大
  • Journal Title: 生物物理化学 52 Pages: 173-176
  • NAID: 10024589319
  • Peer Reviewed
• [Journal Article] Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation. (2007)
  • Author(s): Masaru Kato, Hiroyuki Kinoshita, Mitsue Enokita, Yukiko Hori, Tadafumi Hashimoto, Takeshi Iwatsubo, Toshimasa Toyo'oka
  • Journal Title: Anal. Chem. 79 Pages: 4887-4891
  • Peer Reviewed
• [Journal Article] Development of high efficient separation method for biomolecules (2007)
  • Author(s): M. Kato
  • Journal Title: Yakugaku Zasshi 127 Pages: 2015-2025
  • NAID: 110006546576
  • Peer Reviewed
• [Journal Article] Femto Liquid Chromatography with Atto-Liter Sample Separation in the Extended Nanospace Channel
  • Author(s): M.Kato, M.Inaba, T.Tsukahara, K.Mawatari, A.Hibara, T.Kitamori
  • Journal Title: Analytical Chemistry (in press)
  • Peer Reviewed
• [Presentation] 高性能分離分析法の開発とナノ物質への応用についての研究 (2009)
  • Organizer: 日本分析化学会第58年会
  • Place of Presentation: 札幌
• [Presentation] Development of a Silica-Organic Hydrogel for High-Throughput Screening (2009)
  • Organizer: BioNano2009
  • Place of Presentation: エーグル(スイス)
• [Presentation] キャピラリーゾーン電気泳動と走査型プローブ顕微鏡を用いたβアミロイドの重合反応の解析 (2008)
  • Author(s): 加藤大
  • Organizer: 第21回バイオメディカル分析科学シンポジウム
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2008-08-07
• [Book] 生体分子固定化マイクロチップ. inマイクロ・ナノ化学チップと医療・環境・バイオ分析 (2009)
  • Author(s): 加藤大
  • Publisher: 技術教育出版社
• [Remarks] ホームページ等
  • URL: http://park.itc.u-tokyo.ac.jp/CNBI/kato/index.html
• [Remarks]
  • URL: http://park.itc.u-tokyo.ac.jp/CNBI/kato/index.html
• [Patent(Industrial Property Rights)] ナノカーボン物質分散液とその製造方法、ナノカーボン物質構成体 (2008)
  • Inventor(s): 加藤大、丸山茂夫、相田卓三、福島孝典、山本竜広、宮内雄平
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Industrial Property Number: 2008-033640
  • Filing Date: 2008-02-14
• [Patent(Industrial Property Rights)] 分析方法、及び該分析方法に用いる装置 (2008)
  • Inventor(s): 加藤大、豊岡利正、加藤くみ子
  • Industrial Property Rights Holder: 科学技術振興機構
  • Acquisition Date: 2008-06-13