A study for proper usage of medical device-Control a release of plasticizer-
| Project/Area Number |
19790040
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
ITO Rie Hoshi University, 薬学部, 助教 (90398892)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,540,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 代替可塑剤 / 医療機器 / 暴露量評価 / リスク評価 |
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| Research Abstract |
Tris(2-ethylhexyl)trimellitate (TOTM) is used as an alternative plasticizer of polyvinyl chloride (PVC) medical devices. A method for the determination of TOTM released from PVC medical devices into intravenous preparations was developed, which uses liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition, the effect of sterilization, especially gamma-ray sterilization, on the amount of TOTM release from PVC was studied. When our method was applied to the determination of TOTM released from unsterilized and gamma-ray-sterilized PVC tubes, we found that a higher concentration of TOTM was released from the unsterilized PVC tube than from the gamma-ray-sterilized one. No degradation peak was observed when the gamma-ray irradiated sample was analyzed.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Effect of gamma-ray irradiation on degradation of di(2-ethylhexyl)phthalate in polyvinyl chloride sheet.2009
Author(s)
Ito R, Miura N, Ushiro M, Kawaguchi M, Nakamura H, Iguchi H, Ogino J, Oishi M, Wakui N, Iwasaki Y, Saito K, Nakazawa H
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Journal Title
Int. J. Pharm. 376(1-2)
Pages: 213-218
Related Report
Peer Reviewed
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[Journal Article] Determination of tris(2-ethylhexyl)trimellitate released from PVC tube by LC-MS/MS.2008
Author(s)
Ito R, Miura N, Iguchi H, Nakamura H, Ushiro M, Wakui N, Nakahashi K, Iwasaki Y, Saito K, Suzuki T, Nakazawa H
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Journal Title
Int. J. Pharm. 360(1-2)
Pages: 91-95
Related Report
Peer Reviewed
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