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The effect of novel vanadium compound VO(OPT) in brain ischemia-induced neurogenesis.

Research Project

Project/Area Number 19790045
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionTohoku University

Principal Investigator

SHIODA Norifumi  Tohoku University, 大学院・薬学研究科, 助手 (00374950)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords脳虚血 / 神経新生 / バナジウム化合物 / 認知機能 / Akt / ERK / 歯状回顆粒細胞 / 高次脳機能
Research Abstract

本研究の目的は、新規バナジウム化合物 VO(OPT) による脳虚血後の神経細胞新生促進作用のメカニズムと神経新生と認知機能改善効果の関わりを明らかにすることである。本研究において、バナジウム化合物の神経新生促進作用を確認した。VO(OPT) の特徴として新生ニューロンの産生数を増加させるだけでなく、新生ニューロンの移動・成熟にも影響することが示唆された。さらに、未成熟なニューロンのマーカーを用いて VO(OPT) により新生ニューロンの移動も促進されていることが明らかとなった。最終的に、行動薬理学的な解析によって、VO(OPT) により歯状回顆粒細胞下層で新生した神経細胞が学習・記憶形成に重要な役割を果たしていることが示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (96 results)

All 2009 2008 2007

All Journal Article (34 results) (of which Peer Reviewed: 30 results) Presentation (62 results)

  • [Journal Article] Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation2009

    • Author(s)
      Moriguchi S, Shioda N, Han F, Yeh JZ, Narahashi T, Fukunaga K
    • Journal Title

      Hippocampus (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats2009

    • Author(s)
      Bhuiyan MS, Shioda N, Fukunaga K
    • Journal Title

      Expert Opin Ther Targets 13

      Pages: 275-286

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice2009

    • Author(s)
      Han F, Nakano T, Yamamoto Y, Shioda N, Lu YM, Fukunaga K
    • Journal Title

      Brain Res 1265

      Pages: 205-214

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] DY-9760e Inhibits Endothelin-1-induced Cardiomyocyte Hypertrophy Through Inhibition of CaMKII and ERK Activities2009

    • Author(s)
      Lu YM, Shioda N, Han F, Kamata A, Shirasaki Y, Qin ZH, Fukunaga K
    • Journal Title

      Cardiovasc Ther 27

      Pages: 17-27

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of heart-type fatty acid binding protein in the brain function2009

    • Author(s)
      Motohashi K, Yamamoto Y, Shioda N, Kondo H, Owada Y, Fukunaga K
    • Journal Title

      Yakugaku Zasshi 129

      Pages: 191-195

    • NAID

      110007046096

    • Related Report
      2008 Final Research Report
  • [Journal Article] Activation of endothelial nitric oxide synthase by a vanadium compound ameliorates pressure overload-induced cardiac injury in ovariectomized rats2009

    • Author(s)
      Bhuiyan MS, Shioda N, Shibuya M, Iwabuchi Y, Fukunaga K
    • Journal Title

      Hypertension 53

      Pages: 57-63

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric oxide synthase and ameliorated by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a novel calmodulin antagonist.2009

    • Author(s)
      Lu YM, Han F, Shioda N, Moriguchi S, Shirasaki Y, Qin ZH, Fukunaga K
    • Journal Title

      Mol Pharmacol 75

      Pages: 101-112

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation2009

    • Author(s)
      Moriguchi S, Shioda N, Han F, Yeh JZ, Narahashi T, Fukunaga K.
    • Journal Title

      Hippocampus (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats2009

    • Author(s)
      Bhuiyan MS, Shioda N, Fukunag a K.
    • Journal Title

      Expert Opin Ther Targets 13

      Pages: 275-286

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice2009

    • Author(s)
      Han F, Nakano T, Yamamoto Y, Shioda N, Lu YM, Fukunaga K
    • Journal Title

      Brain Res (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DY-9760e Inhibits Endothelin-l-induced Cardiomyocyte Hypertrophy Through Inhibition of CaMKII and ERK Activities2009

    • Author(s)
      Lu YM, Shioda N, Han F, Kamata A, Shirasaki Y, Qin ZH, Fukunaga K.
    • Journal Title

      Cardiovasc Ther 27

      Pages: 17-27

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of heart-type fatty acid binding protein in the brain function2009

    • Author(s)
      Motohashi K, Yamamoto Y, Shioda N, Kondo H, Owada Y, Fukunaga K.
    • Journal Title

      Yakugaku Zasshi 129

      Pages: 191-195

    • NAID

      110007046096

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Activation of endothelial nitric oxide synthase by a vanadium compound ameliorates pressure overload-induced cardiac injury in ovariectomized rats2009

    • Author(s)
      Bhuiyan MS, Shioda N, Shibuya M, Iwabuchi Y, Fukunaga K.
    • Journal Title

      Hypertension 53

      Pages: 57-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric-oxide synthase and ameliorated by 3-[2-[4-(3-chloro-2-methylpheny1)-1-piperazinyl]ethyl]-5, 6-dimethoxyi ndazole (DY-9836). a novel calmodulin antagonist2009

    • Author(s)
      Lu YM, Han F, Shioda N, Moriguchi S, Shiraki Y, Qin zh, Fukunaga K
    • Journal Title

      Mol Pharmacol 75

      Pages: 101-112

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting protein kinase B/Akt signaling with vanadium compounds for cardioprotection2008

    • Author(s)
      Bhuiyan MS, Shioda N, Fukunaga K
    • Journal Title

      Expert Opin Ther Targets 12

      Pages: 1217-1227

    • Related Report
      2008 Final Research Report
  • [Journal Article] Novel therapeutic strategy for neurogenesis in the neurodegenerative disorders2008

    • Author(s)
      Fukunaga K, Shioda N, Morioka M, Han F
    • Journal Title

      Nippon Yakurigaku Zasshi 131

      Pages: 341-346

    • NAID

      10024382659

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia2008

    • Author(s)
      Shioda N, Han F, Morioka M, Fukunaga K
    • Journal Title

      Neuroscience 155

      Pages: 876-887

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein2008

    • Author(s)
      Bhuiyan MS, Takada Y, Shioda N, Moriguchi S, Kasahara J, Fukunaga K
    • Journal Title

      Cardiovasc Ther 26

      Pages: 10-23

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region J Neurochem2008

    • Author(s)
      Moriguchi S, Shioda N, Han F, Narahashi T, Fukunaga K
    • Journal Title

      106

      Pages: 1092-1103

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia2008

    • Author(s)
      Shioda N, Han F, Morioka M, F ukunaga K.
    • Journal Title

      Neuroscience 155

      Pages: 876-887

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting protein kinase B/Akt signaling with vanadium compounds for catclioprotection2008

    • Author(s)
      Bhuiyan MS, Shioda N, Fukunag a K.
    • Journal Title

      Expert Opin Ther Targets 12

      Pages: 1217-1227

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Novel therapeutic strategy for neurogenesis in the neurodegenerative disorders2008

    • Author(s)
      Fukunaga K, Shioda N, Morioka M, Han F.
    • Journal Title

      Nippon Yakurigaku Zasshi 131

      Pages: 341-346

    • NAID

      10024382659

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein2008

    • Author(s)
      Bhuiyan MS, Takada Y, Shioda N, Moriguchi S, Kasahara J, Fukunaga K.
    • Journal Title

      Cardiovasc Ther 26

      Pages: 10-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CaM kinase II and protein kinase C activations mediate enhancement of lone-term potentiation by nefiracetam in the rat hinnocamnal CA1 region2008

    • Author(s)
      Moriguchi S, Shioda N, Han F, Narahashi T, Fukunaga K.
    • Journal Title

      J Neurochem 106

      Pages: 1092-1103

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of beta-amyloid in the brain microvessels accompanies increased hyperphosphorylated tau proteins following microsphere embolism in aged rats.2008

    • Author(s)
      F. Han, A.A. Raie, N. Shioda, Z.H. Qin, K. Fukunaga
    • Journal Title

      Neuroscience (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ZSET1446 (ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating CaM kinase II and protein kinase C in mouse hippocampus.2008

    • Author(s)
      F. Han, N. Shioda, S. Moriguchi, Y. Yamamoto, A.A. Raie, Y. Yamaguchi, M. Hino, K. Fukunaga.
    • Journal Title

      J Pharmacol Exp Ther. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vanadium compounds enhance adult neurogenesis after brain ischemia.2008

    • Author(s)
      N. Shioda, M. Morioka, K. Fukunaga.
    • Journal Title

      Yakugaku Zasshi. 128

      Pages: 413-417

    • NAID

      110006646595

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism.2008

    • Author(s)
      F. Han, N. Shioda, S. Moriguchi, Z.H. Qin, K. Fukunaga.
    • Journal Title

      Neurosci Lett. 430

      Pages: 275-280

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes.2007

    • Author(s)
      Y-M. Lu, N. Shioda, F. Han, S. Moriguchi, J. Kasahara, Y. Shirasaki, Z.H. Qin, K. Fukunaga.
    • Journal Title

      Biochem Pharmacol. 74

      Pages: 1727-1737

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats.2007

    • Author(s)
      M.S. Bhuiyan, N. Shioda and K. Fukunaga.
    • Journal Title

      Am J Physiol Endocrinol Metab. 293

      Pages: 1606-1614

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective effect of bis (1-oxy-2-pyridinethiolato) oxovanadiun (IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression.2007

    • Author(s)
      M.S. Bhuiyan, M. Shibuya, N. Shioda, S. Moriguchi, J. Kasahara, Y. Iwabuchi and K. Fukunaga
    • Journal Title

      European Journal of Pharmacology 571

      Pages: 180-188

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nefiracetam potentiates NMDA receptor function via PKC activation and reduces magnesium block of NMDA receptor.2007

    • Author(s)
      S. Moriguchi, N. Shioda, H. Maejima, X. Zhao, W. Marszalec, J.Z. Yeh, K. Fukunaga and T. Narahashi
    • Journal Title

      Molecular Pharmacology 71

      Pages: 580-587

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia.2007

    • Author(s)
      N. Shioda, F. Han, S. Moriguchi and K. Fukunaga
    • Journal Title

      Journal of Neurochemistry 102

      Pages: 1506-1517

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of PI3K/Akt pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia.2007

    • Author(s)
      N. Shioda, T. Ishigami, F. Han, S. Moriguchi, M. Shibuya, Y. Iwabuchi and K. Fukunaga
    • Journal Title

      Neuroscience 148

      Pages: 221-229

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation]2009

    • Author(s)
      塩田倫史、山本由似、大和田祐二、福永浩司
    • Organizer
      第18回神経行動薬理若手研究者の集い
    • Place of Presentation
      横浜情報文化センター 情文ホール
    • Year and Date
      2009-03-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪酸輸送タンパク質によるドパミンD2受容体の制御機構2009

    • Author(s)
      塩田倫史、山本由似、大和田祐二、福永浩司(口演)
    • Organizer
      第18回神経行動薬理若手研究者の集い
    • Place of Presentation
      横浜情報文化センター情文ホール
    • Year and Date
      2009-03-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Na+/Ca2+交換体(NCX)type2欠損マウスにおける細胞内カルシウム異常と認知機能障害2009

    • Author(s)
      森口茂樹、韓峰、塩田倫史、喜多紗斗美、小室一成、岩本隆宏、福永浩司
    • Organizer
      第18回神経行動薬理若手研究者の集い
    • Place of Presentation
      横浜情報文化センター情文ホール
    • Year and Date
      2009-03-19
    • Related Report
      2008 Annual Research Report
  • [Presentation]2009

    • Author(s)
      塩田倫史、福永浩司
    • Organizer
      日本薬学会 第129年会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2008 Final Research Report
  • [Presentation]2009

    • Author(s)
      塩田倫史、別府秀幸 、北島勲 、福永浩司
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪酸結合蛋白質によるドパミンD2受容体の新しい機能制御2009

    • Author(s)
      福永浩司、塩田倫史、山本由似、大和田祐二(シンポジウム)
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Na+/Ca2+交換体欠損マウスにおける認知機能障害にはカルシウム/カルモデュリン依存性プロテインキナーゼIIの活性低下が関与する2009

    • Author(s)
      森口茂樹、韓峰、塩田倫史、喜多紗斗美、小室一成、岩本隆宏、福永浩司(口演)
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 可溶性Fas-ligandは脳虚血における神経細胞死に関与する2009

    • Author(s)
      塩田倫史、福永浩司(口演)
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2008 Annual Research Report
  • [Presentation] フェニレフリンによる心筋障害における内皮型NOSの病態生理学的役割2009

    • Author(s)
      福永浩司、Ying-Mei LU、塩田倫史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2008 Annual Research Report
  • [Presentation] ドネペジルによるマウス中隔野アセチルコリン神経保護作用2009

    • Author(s)
      山本由似、塩田倫史、韓峰、森口茂樹、福永浩司(学生シンポジウム)
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2008 Annual Research Report
  • [Presentation] Na+/Ca2+交換体(NCX)による神経細胞内カルシウムと認知機能調節2008

    • Author(s)
      森口茂樹、韓峰、塩田倫史、喜多紗斗美、小室一成、岩本隆宏、福永浩司
    • Organizer
      トランスポーターワークショップIN福岡
    • Place of Presentation
      福岡
    • Year and Date
      2008-11-02
    • Related Report
      2008 Annual Research Report
  • [Presentation]2008

    • Author(s)
      塩田倫史、所崇、別府秀幸、北島勲、福永浩司
    • Organizer
      第47回日本薬学会東北支部大会
    • Place of Presentation
      岩手医科大学薬学部
    • Year and Date
      2008-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 精神遅滞関連遺伝子ATRX変異マウスのスパイン形成異常とそのメカニズム2008

    • Author(s)
      塩田倫史、所崇、別府秀幸、北島勲、福永浩司(口演)
    • Organizer
      第47回日本薬学会東北支部大会
    • Place of Presentation
      岩手医科大学薬学部
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 嗅球摘出マウスにおけるDonepezilによるアセチルコリン神経保護作用2008

    • Author(s)
      山本由似、塩田倫史、韓峰、森口茂樹、福永浩司(口演)
    • Organizer
      第47回日本薬学会東北支部大会
    • Place of Presentation
      岩手医科大学薬学部
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation]2008

    • Author(s)
      塩田倫史,福永浩司
    • Organizer
      第59回日本薬理学会北部会
    • Place of Presentation
      仙台市情報・産業プラザ
    • Year and Date
      2008-09-27
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳虚血におけるsoluble Fas-ligand発現と神経細胞死2008

    • Author(s)
      塩田倫史, 福永浩司(口演)
    • Organizer
      第59回日本薬理学会北部会
    • Place of Presentation
      仙台市情報・産業プラザ
    • Year and Date
      2008-09-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 嗅球摘出マウスにおけるドネペジルによるアセチルコリン神経保護作用2008

    • Author(s)
      山本由似、塩田倫史、韓峰、森口茂樹、福永浩司(口演)
    • Organizer
      第59回日本薬理学会北部会
    • Place of Presentation
      仙台市情報・産業プラザ
    • Year and Date
      2008-09-27
    • Related Report
      2008 Annual Research Report
  • [Presentation]2008

    • Author(s)
      塩田倫史、所崇、別府秀幸、北島勲、福永浩司
    • Organizer
      日本生化学会東北支部第74回例会・シンポジウム
    • Place of Presentation
      アイーナ 岩手県民情報交流センター
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] クロマチンリモデリング蛋白質ATRX変異マウスのスパイン形成異常とそのメカニズム2008

    • Author(s)
      塩田倫史、所崇、別府秀幸、北島勲、福永浩司(口演)
    • Organizer
      日本生化学会東北支部第74回例会・シンポジウム
    • Place of Presentation
      アイーナ岩手県民情報交流センター
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高次脳機能における心臓型脂肪酸結合蛋白質(H-FABP)の役割2008

    • Author(s)
      本橋慧樹、橋本茜、塩田倫史、近藤尚武、大和田祐二、福永浩司(シンポジウム)
    • Organizer
      日本薬学会 第128年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 嗅球摘出マウスにおける神経新生低下とうつ症状発現の経時的変化2008

    • Author(s)
      橋本 茜、韓 峰、塩田倫史、福永浩司(口演)
    • Organizer
      第17回神経行動薬理若手研究者の集い
    • Place of Presentation
      横浜情報文化センター
    • Year and Date
      2008-03-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 認知機能改善薬ZSET1446の海馬歯状回における神経新生促進効果とそのメカニズム2008

    • Author(s)
      塩田倫史、韓 峰、山本由似、森口茂樹、山口芳正、日野正孝、福永浩司(口演)
    • Organizer
      第17回神経行動薬理若手研究者の集い
    • Place of Presentation
      横浜情報文化センター
    • Year and Date
      2008-03-16
    • Related Report
      2007 Annual Research Report
  • [Presentation]2008

    • Author(s)
      塩田倫史,福永浩司
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京ドームホテル
    • Related Report
      2008 Final Research Report
  • [Presentation]2008

    • Author(s)
      Norifumi Shioda, Takashi Tokoro, Hideyuki Beppu, Isao Kitajima and Kohji Fukunaga
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山国際会議場
    • Related Report
      2008 Final Research Report
  • [Presentation]2008

    • Author(s)
      塩田倫史、福永 浩司
    • Organizer
      第19回霧島神経薬理フォーラム
    • Place of Presentation
      日本文理大学 湯布院研修所
    • Related Report
      2008 Final Research Report
  • [Presentation]2008

    • Author(s)
      Norifumi Shioda, Takashi Tokoro, Hideyuki Beppu, Isao Kitajima and Kohji Fukunaga
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳虚血に伴うCaMKII活性低下は学習記憶障害に関与している2008

    • Author(s)
      山本由似、塩田倫史、森口茂樹、福永浩司(口演)
    • Organizer
      第10回ブレインサイエンス
    • Place of Presentation
      マリンテラスあしや
    • Related Report
      2008 Annual Research Report
  • [Presentation] Activation of CaMKII mediates abnormal dendritic spine formation viaRacl-GEF/PAK signaling in ATRX mutant mouse brain2008

    • Author(s)
      Norifumi Shioda, Takashi Tokoro, Hidleyuki Beppu, Isao Kitaiima and Kohji Fukunaea
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel cognitive enhancer rescues olfactory bulbectomy-induced memory impairment through stimulation of CaMKII and PKC signalings in mouse hippocampus2008

    • Author(s)
      Fang Han, Norifumi Shioda, Shigeld Moriguchi, Yoshimasa Yamag-uchi, Masataka Hino and Kohji Fukunaga
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      Chicago USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] The vanadium (IV) compound ameliorates OBX-induced neurodegenerati on of the septo-hippocampal cholinergic neurons through Akt and ERK nathways2008

    • Author(s)
      Kohji Fukunaga, Feng Han, Shigeld Moriguchi and Norifumi Shicula
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      Chicago USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Potentiation of calciumicalmoclulin-dependent protein kinase II benefits for cognitive enhancement in Alzheimer's disease patients2008

    • Author(s)
      Shigeki Moriguchi, Feng Han, Norifumi Shioda, Toshio Narahashi and Kohii Fukunaga
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      Chicago USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fas/Fas-ligandのアポトーシスシグナル伝達は脳虚血による神経細胞死に関与する2008

    • Author(s)
      塩田倫史、福永浩司(口演)
    • Organizer
      第19回霧島神経薬理フォーラム
    • Place of Presentation
      日本文理大学湯布院研修所
    • Related Report
      2008 Annual Research Report
  • [Presentation] アルツハイマー治療薬ドネペジルはアセチルコリン神経保護作用を有する2008

    • Author(s)
      山本由似、塩田倫史、韓峰、森口茂樹、福永浩司(口演)
    • Organizer
      第19回霧島神経薬理フォーラム
    • Place of Presentation
      日本文理大学湯布院研修所
    • Related Report
      2008 Annual Research Report
  • [Presentation] Abnormal dendritic spine formation via CaMKII/Racl-GEF/PAK signaling in X-linked mental retardation model mouse2008

    • Author(s)
      Norifumi Shioda, Takashi Tokoro, Hideynki Beppu,Isao Ritajim a2 and Kohji Fukunaga
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel cognitive enhancer, ZSET1446 improves olfactory bulbectomy inuced memory impairment through CaMKII and PKC activation in mouse hippocampus2008

    • Author(s)
      Yui yamamoto, Feng Han, Norifunki Shioda, Shigeki Moriguchi Kohil Fukunaga(Poster)
    • Organizer
      XI Workshop on Apoptosis in Biology and Medicine
    • Place of Presentation
      Tohoku Pharmaceutical University
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス中大脳動脈閉塞虚血におけるsoluble Fas ligahdと神経細胞死2008

    • Author(s)
      塩田倫史, 福永浩司
    • Organizer
      第20回日本脳循環代謝学会総会
    • Place of Presentation
      東京ドームホテル
    • Related Report
      2008 Annual Research Report
  • [Presentation] CaMKIIの活性異常は精神遅滞モデルマウスにおけるスパイン形態異常に関与する2008

    • Author(s)
      塩田倫史、別府秀幸、北島勲、福永浩司(口演)
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 心臓型脂肪酸結合蛋白質欠損マウスの神経薬理学的表現型2008

    • Author(s)
      山本由似、本橋慧樹、塩田倫史、大和田祐二、福永浩司(口演)
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] ZSET1446はCaMKIIとPKCを活性化して嗅球除去マウスの記憶障害を改善する2008

    • Author(s)
      韓 峰、塩田倫史、森口茂樹、山口芳正、日野正孝、福永浩司(口演)
    • Organizer
      第81回 日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 認知機能改善薬ZSET1446は嗅球摘出マウスにおける海馬の神経新生を促進してうつ症状を改善する2008

    • Author(s)
      塩田倫史、韓 峰、森口茂樹、山口芳正、日野正孝、福永浩司(口演)
    • Organizer
      第81回 日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Impairments of Akt and eNOS signalings by pressure overload aggravates isoproterenol-induced heart failure in ovariectomized female rats.2008

    • Author(s)
      Md. Shenuarin Bhuiyan, Norifumi Shioda and Kohji Fukunaga(口演)
    • Organizer
      第81回 日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] フェニレフリン誘導による心筋障害に対してDY-9836は活性酸素産生とカベオリン3の分解を抑制して心筋細胞を保護する2008

    • Author(s)
      Ying Mei Lu、塩田倫史、白崎康文福永浩司(口演)
    • Organizer
      第81回 日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脳虚血におけるFasリガンドの誘導と神経細胞死2008

    • Author(s)
      塩田倫史、福永浩司(口演)
    • Organizer
      日本薬学会 第128年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高次脳機能における心臓型脂肪酸結合蛋白質(H-FABP)の役割2007

    • Author(s)
      本橋慧樹、橋本茜、塩田倫史、近藤尚武、大和田祐二、福永浩司(口演)
    • Organizer
      第60回日本薬理学会西南部会
    • Place of Presentation
      宮崎県 宮崎市
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 4価バナジウム化合物VO(OPT)は脳虚血における神経新生を促進する。2007

    • Author(s)
      塩田倫史、澁谷正俊、岩渕好治、福永浩司(口演)
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      東北薬科大学
    • Year and Date
      2007-10-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウス両総頸動脈結紮モデルにおけるnobiletinの神経保護作用2007

    • Author(s)
      山本由似、塩田倫史、中島晶、山國徹、大泉康、福永浩司(口演)
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      東北薬科大学
    • Year and Date
      2007-10-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウス中大脳動脈閉塞ペナンブラ領域におけるFas ligandの発現機序2007

    • Author(s)
      塩田倫史、福永浩司(口演)
    • Organizer
      第58回日本薬理学会北部会
    • Place of Presentation
      北海道 札幌市
    • Year and Date
      2007-09-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] アセチルコリンと神経新生2007

    • Author(s)
      塩田倫史(口演)
    • Organizer
      生体情報と創薬フォーラム/国際高等融合領域研究所セミナー
    • Place of Presentation
      東北大学薬学研究科
    • Year and Date
      2007-09-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 中枢神経系における脂肪酸の機能制御因子としての心臓型脂肪酸結合タンパク質(H-FABP)2007

    • Author(s)
      本橋慧樹、橋本茜、塩田倫史、近藤尚武、大和田祐二、福永浩司(口演)
    • Organizer
      第18回霧島神経薬理フォーラム
    • Place of Presentation
      見奈良天然温泉 利楽
    • Year and Date
      2007-08-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] A NOVEL STIMULANT OF NEUROGENESIS FOLLOWING MOUSE BRAIN ISCHEMIA VIAPI3K/AKT AND ERK ACTIVATION IN THE SUBGRANULAR ZONE OF HIPPOCAMPUS2007

    • Author(s)
      Norifumi Shioda and Kohji Fukunaga (Poster)
    • Organizer
      BRAIN'07&BRAINPET'07
    • Place of Presentation
      大阪国際会議場(グランキューブ大阪)(大阪)
    • Related Report
      2007 Annual Research Report
  • [Presentation] NefiracetamによるNMDA受容体賦活作用はprotein kinase Cを介する2007

    • Author(s)
      森口茂樹、塩田倫史、楢橋敏夫、福永浩司(口演)
    • Organizer
      第30回 日本神経科学大会 第50回 日本神経化学会大会第17回 日本神経回路学会大会(Neuro2007)
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規バナジウム化合物はAktとERKを介して脳虚血後の海馬歯状回における神経新生を亢進する。2007

    • Author(s)
      塩田倫史、福永浩司(poster)
    • Organizer
      第30回 日本神経科学大会 第50回 日本神経化学会大会第17回 日本神経回路学会大会(Neuro2007)
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Chronic treatment of methylphenidate injures behavioral/cognitive functions by degeneration of dopaminergic neuron in rats.2007

    • Author(s)
      Sara Wardhani, Shioda Norifumi, Kohji Fukunaga (poster)
    • Organizer
      第30回 日本神経科学大会 第50回 日本神経化学会大会第17回 日本神経回路学会大会(Neuro2007)
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 認知機能改善薬ZSET1446は嗅球摘出マウスの海馬歯状回における神経新生を促進し、うつ症状を改善する2007

    • Author(s)
      塩田倫史、韓峰、森口茂樹、山口芳正、日野正孝、福永浩司(poster)
    • Organizer
      生体機能と創薬シンポジウム2007
    • Place of Presentation
      金沢
    • Related Report
      2007 Annual Research Report
  • [Presentation] 若年ラットにおけるメチルフェニデート慢性投与によるドパミン神経障害と認知機能障害2007

    • Author(s)
      Sara Wardhani, 塩田倫史、福永浩司(poster)
    • Organizer
      生体機能と創薬シンポジウム2007
    • Place of Presentation
      金沢
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウス中大脳動脈閉塞モデルにおけるFas ligand の発現と神経細胞死2007

    • Author(s)
      塩田倫史、福永浩司(口演)
    • Organizer
      第19回日本脳循環代謝学会総会
    • Place of Presentation
      ホテルメトロポリタン盛岡NEW WING
    • Related Report
      2007 Annual Research Report
  • [Presentation] The chromatin-remodeling gene ATRX mutant mice exhibit abnormal behaviors and learning impairment related to ADHD.2007

    • Author(s)
      T Tokoro, H Beppu, S Moriguchi, N Shioda, K Fukunaga, H Nishijo, I Kitajima and E Li(poster)
    • Organizer
      37th. Society for Neuroscience; Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effects of a novel cognitive enhancer, ZSETI446 on depressive behavior and neurogenesis in the dentate gyrus of olfactory bulbectomized mice.2007

    • Author(s)
      Y Yamaguchi, N Shioda, F Han, S Moriguchi, M Hino and K Fukunaga(poster)
    • Organizer
      37th. Society for Neuroscience; Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2007 Annual Research Report
  • [Presentation] Impairment of CaM kinase II underlies memory deficits and depressive behaviors in the olfactory bulbectomized mice.2007

    • Author(s)
      F Han, T Nakano, N Shioda, S Moriguchi, M Morioka and K Fukunaga(poster)
    • Organizer
      37th. Society for Neuroscience; Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2007 Annual Research Report
  • [Presentation] The vanadyl compound enhances proliferation and migration of new neurons following brain ischemia through PI3K/Akt and ERK pathways.2007

    • Author(s)
      Kohji Fukunaga and Norifumi Shioda (poster)
    • Organizer
      37th. Society for Neuroscience; Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2007 Annual Research Report
  • [Presentation] Activation of CaM kinase II is implicated in generation of abnormal dendritic spines via Tiam1/PAK signaling in ATRX mutant mouse brain.2007

    • Author(s)
      Norifumi Shioda, Takashi Tokoro, Isao Kitajima, Hideyuki Beppu and Kohji Fukunaga(poster)
    • Organizer
      37th. Society for Neuroscience; Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pathological relevance of impaired Akt and eNOS signalings in cardiac hypertrophy in ovariectomized female rats.2007

    • Author(s)
      Md. Shenuarin Bhuiyan, Norifumi Shioda, Kohji Fukunaga(口演)
    • Organizer
      The 7th Japan-Korea joint symposium of brain sciences, and cardiac and smooth muscles
    • Place of Presentation
      Sendai
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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