The effect of novel vanadium compound VO(OPT) in brain ischemia-induced neurogenesis.

• Project/Area Number: 19790045
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: SHIODA Norifumi Tohoku University, 大学院・薬学研究科, 助手 (00374950)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 脳虚血 / 神経新生 / バナジウム化合物 / 認知機能 / Akt / ERK / 歯状回顆粒細胞 / 高次脳機能

Research Abstract

本研究の目的は、新規バナジウム化合物 VO(OPT) による脳虚血後の神経細胞新生促進作用のメカニズムと神経新生と認知機能改善効果の関わりを明らかにすることである。本研究において、バナジウム化合物の神経新生促進作用を確認した。VO(OPT) の特徴として新生ニューロンの産生数を増加させるだけでなく、新生ニューロンの移動・成熟にも影響することが示唆された。さらに、未成熟なニューロンのマーカーを用いて VO(OPT) により新生ニューロンの移動も促進されていることが明らかとなった。最終的に、行動薬理学的な解析によって、VO(OPT) により歯状回顆粒細胞下層で新生した神経細胞が学習・記憶形成に重要な役割を果たしていることが示唆された。

Research Products

• [Journal Article] Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation (2009)
  • Author(s): Moriguchi S, Shioda N, Han F, Yeh JZ, Narahashi T, Fukunaga K
  • Journal Title: Hippocampus (in press)
  • Peer Reviewed
• [Journal Article] Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats (2009)
  • Author(s): Bhuiyan MS, Shioda N, Fukunaga K
  • Journal Title: Expert Opin Ther Targets 13 Pages: 275-286
  • Peer Reviewed
• [Journal Article] Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice (2009)
  • Author(s): Han F, Nakano T, Yamamoto Y, Shioda N, Lu YM, Fukunaga K
  • Journal Title: Brain Res 1265 Pages: 205-214
  • Peer Reviewed
• [Journal Article] DY-9760e Inhibits Endothelin-1-induced Cardiomyocyte Hypertrophy Through Inhibition of CaMKII and ERK Activities (2009)
  • Author(s): Lu YM, Shioda N, Han F, Kamata A, Shirasaki Y, Qin ZH, Fukunaga K
  • Journal Title: Cardiovasc Ther 27 Pages: 17-27
  • Peer Reviewed
• [Journal Article] Role of heart-type fatty acid binding protein in the brain function (2009)
  • Author(s): Motohashi K, Yamamoto Y, Shioda N, Kondo H, Owada Y, Fukunaga K
  • Journal Title: Yakugaku Zasshi 129 Pages: 191-195
  • NAID: 110007046096
• [Journal Article] Activation of endothelial nitric oxide synthase by a vanadium compound ameliorates pressure overload-induced cardiac injury in ovariectomized rats (2009)
  • Author(s): Bhuiyan MS, Shioda N, Shibuya M, Iwabuchi Y, Fukunaga K
  • Journal Title: Hypertension 53 Pages: 57-63
  • Peer Reviewed
• [Journal Article] Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric oxide synthase and ameliorated by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a novel calmodulin antagonist. (2009)
  • Author(s): Lu YM, Han F, Shioda N, Moriguchi S, Shirasaki Y, Qin ZH, Fukunaga K
  • Journal Title: Mol Pharmacol 75 Pages: 101-112
  • Peer Reviewed
• [Journal Article] Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation (2009)
  • Author(s): Moriguchi S, Shioda N, Han F, Yeh JZ, Narahashi T, Fukunaga K.
  • Journal Title: Hippocampus (in press)
  • Peer Reviewed
• [Journal Article] Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats (2009)
  • Author(s): Bhuiyan MS, Shioda N, Fukunag a K.
  • Journal Title: Expert Opin Ther Targets 13 Pages: 275-286
  • Peer Reviewed
• [Journal Article] Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice (2009)
  • Author(s): Han F, Nakano T, Yamamoto Y, Shioda N, Lu YM, Fukunaga K
  • Journal Title: Brain Res (in press)
  • Peer Reviewed
• [Journal Article] DY-9760e Inhibits Endothelin-l-induced Cardiomyocyte Hypertrophy Through Inhibition of CaMKII and ERK Activities (2009)
  • Author(s): Lu YM, Shioda N, Han F, Kamata A, Shirasaki Y, Qin ZH, Fukunaga K.
  • Journal Title: Cardiovasc Ther 27 Pages: 17-27
  • Peer Reviewed
• [Journal Article] Role of heart-type fatty acid binding protein in the brain function (2009)
  • Author(s): Motohashi K, Yamamoto Y, Shioda N, Kondo H, Owada Y, Fukunaga K.
  • Journal Title: Yakugaku Zasshi 129 Pages: 191-195
  • NAID: 110007046096
• [Journal Article] Activation of endothelial nitric oxide synthase by a vanadium compound ameliorates pressure overload-induced cardiac injury in ovariectomized rats (2009)
  • Author(s): Bhuiyan MS, Shioda N, Shibuya M, Iwabuchi Y, Fukunaga K.
  • Journal Title: Hypertension 53 Pages: 57-63
  • Peer Reviewed
• [Journal Article] Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric-oxide synthase and ameliorated by 3-[2-[4-(3-chloro-2-methylpheny1)-1-piperazinyl]ethyl]-5, 6-dimethoxyi ndazole (DY-9836). a novel calmodulin antagonist (2009)
  • Author(s): Lu YM, Han F, Shioda N, Moriguchi S, Shiraki Y, Qin zh, Fukunaga K
  • Journal Title: Mol Pharmacol 75 Pages: 101-112
  • Peer Reviewed
• [Journal Article] Targeting protein kinase B/Akt signaling with vanadium compounds for cardioprotection (2008)
  • Author(s): Bhuiyan MS, Shioda N, Fukunaga K
  • Journal Title: Expert Opin Ther Targets 12 Pages: 1217-1227
• [Journal Article] Novel therapeutic strategy for neurogenesis in the neurodegenerative disorders (2008)
  • Author(s): Fukunaga K, Shioda N, Morioka M, Han F
  • Journal Title: Nippon Yakurigaku Zasshi 131 Pages: 341-346
  • NAID: 10024382659
  • Peer Reviewed
• [Journal Article] Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia (2008)
  • Author(s): Shioda N, Han F, Morioka M, Fukunaga K
  • Journal Title: Neuroscience 155 Pages: 876-887
  • Peer Reviewed
• [Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein (2008)
  • Author(s): Bhuiyan MS, Takada Y, Shioda N, Moriguchi S, Kasahara J, Fukunaga K
  • Journal Title: Cardiovasc Ther 26 Pages: 10-23
  • Peer Reviewed
• [Journal Article] CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region J Neurochem (2008)
  • Author(s): Moriguchi S, Shioda N, Han F, Narahashi T, Fukunaga K
  • Journal Title: 106 Pages: 1092-1103
  • Peer Reviewed
• [Journal Article] Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia (2008)
  • Author(s): Shioda N, Han F, Morioka M, F ukunaga K.
  • Journal Title: Neuroscience 155 Pages: 876-887
  • Peer Reviewed
• [Journal Article] Targeting protein kinase B/Akt signaling with vanadium compounds for catclioprotection (2008)
  • Author(s): Bhuiyan MS, Shioda N, Fukunag a K.
  • Journal Title: Expert Opin Ther Targets 12 Pages: 1217-1227
• [Journal Article] Novel therapeutic strategy for neurogenesis in the neurodegenerative disorders (2008)
  • Author(s): Fukunaga K, Shioda N, Morioka M, Han F.
  • Journal Title: Nippon Yakurigaku Zasshi 131 Pages: 341-346
  • NAID: 10024382659
  • Peer Reviewed
• [Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein (2008)
  • Author(s): Bhuiyan MS, Takada Y, Shioda N, Moriguchi S, Kasahara J, Fukunaga K.
  • Journal Title: Cardiovasc Ther 26 Pages: 10-23
  • Peer Reviewed
• [Journal Article] CaM kinase II and protein kinase C activations mediate enhancement of lone-term potentiation by nefiracetam in the rat hinnocamnal CA1 region (2008)
  • Author(s): Moriguchi S, Shioda N, Han F, Narahashi T, Fukunaga K.
  • Journal Title: J Neurochem 106 Pages: 1092-1103
  • Peer Reviewed
• [Journal Article] Accumulation of beta-amyloid in the brain microvessels accompanies increased hyperphosphorylated tau proteins following microsphere embolism in aged rats. (2008)
  • Author(s): F. Han, A.A. Raie, N. Shioda, Z.H. Qin, K. Fukunaga
  • Journal Title: Neuroscience (in press)
  • Peer Reviewed
• [Journal Article] ZSET1446 (ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating CaM kinase II and protein kinase C in mouse hippocampus. (2008)
  • Author(s): F. Han, N. Shioda, S. Moriguchi, Y. Yamamoto, A.A. Raie, Y. Yamaguchi, M. Hino, K. Fukunaga.
  • Journal Title: J Pharmacol Exp Ther. (in press)
  • Peer Reviewed
• [Journal Article] Vanadium compounds enhance adult neurogenesis after brain ischemia. (2008)
  • Author(s): N. Shioda, M. Morioka, K. Fukunaga.
  • Journal Title: Yakugaku Zasshi. 128 Pages: 413-417
  • NAID: 110006646595
  • Peer Reviewed
• [Journal Article] Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism. (2008)
  • Author(s): F. Han, N. Shioda, S. Moriguchi, Z.H. Qin, K. Fukunaga.
  • Journal Title: Neurosci Lett. 430 Pages: 275-280
  • Peer Reviewed
• [Journal Article] Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes. (2007)
  • Author(s): Y-M. Lu, N. Shioda, F. Han, S. Moriguchi, J. Kasahara, Y. Shirasaki, Z.H. Qin, K. Fukunaga.
  • Journal Title: Biochem Pharmacol. 74 Pages: 1727-1737
  • Peer Reviewed
• [Journal Article] Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats. (2007)
  • Author(s): M.S. Bhuiyan, N. Shioda and K. Fukunaga.
  • Journal Title: Am J Physiol Endocrinol Metab. 293 Pages: 1606-1614
  • Peer Reviewed
• [Journal Article] Cytoprotective effect of bis (1-oxy-2-pyridinethiolato) oxovanadiun (IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression. (2007)
  • Author(s): M.S. Bhuiyan, M. Shibuya, N. Shioda, S. Moriguchi, J. Kasahara, Y. Iwabuchi and K. Fukunaga
  • Journal Title: European Journal of Pharmacology 571 Pages: 180-188
  • Peer Reviewed
• [Journal Article] Nefiracetam potentiates NMDA receptor function via PKC activation and reduces magnesium block of NMDA receptor. (2007)
  • Author(s): S. Moriguchi, N. Shioda, H. Maejima, X. Zhao, W. Marszalec, J.Z. Yeh, K. Fukunaga and T. Narahashi
  • Journal Title: Molecular Pharmacology 71 Pages: 580-587
  • Peer Reviewed
• [Journal Article] Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia. (2007)
  • Author(s): N. Shioda, F. Han, S. Moriguchi and K. Fukunaga
  • Journal Title: Journal of Neurochemistry 102 Pages: 1506-1517
  • Peer Reviewed
• [Journal Article] Activation of PI3K/Akt pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia. (2007)
  • Author(s): N. Shioda, T. Ishigami, F. Han, S. Moriguchi, M. Shibuya, Y. Iwabuchi and K. Fukunaga
  • Journal Title: Neuroscience 148 Pages: 221-229
  • Peer Reviewed
• [Presentation] (2009)
  • Author(s): 塩田倫史、山本由似、大和田祐二、福永浩司
  • Organizer: 第18回神経行動薬理若手研究者の集い
  • Place of Presentation: 横浜情報文化センター 情文ホール
  • Year and Date: 2009-03-19
• [Presentation] 脂肪酸輸送タンパク質によるドパミンD2受容体の制御機構 (2009)
  • Author(s): 塩田倫史、山本由似、大和田祐二、福永浩司(口演)
  • Organizer: 第18回神経行動薬理若手研究者の集い
  • Place of Presentation: 横浜情報文化センター情文ホール
  • Year and Date: 2009-03-19
• [Presentation] Na+/Ca2+交換体(NCX)type2欠損マウスにおける細胞内カルシウム異常と認知機能障害 (2009)
  • Author(s): 森口茂樹、韓峰、塩田倫史、喜多紗斗美、小室一成、岩本隆宏、福永浩司
  • Organizer: 第18回神経行動薬理若手研究者の集い
  • Place of Presentation: 横浜情報文化センター情文ホール
  • Year and Date: 2009-03-19
• [Presentation] (2009)
  • Author(s): 塩田倫史、福永浩司
  • Organizer: 日本薬学会 第129年会
  • Place of Presentation: 国立京都国際会館
• [Presentation] (2009)
  • Author(s): 塩田倫史、別府秀幸 、北島勲 、福永浩司
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 脂肪酸結合蛋白質によるドパミンD2受容体の新しい機能制御 (2009)
  • Author(s): 福永浩司、塩田倫史、山本由似、大和田祐二(シンポジウム)
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Na+/Ca2+交換体欠損マウスにおける認知機能障害にはカルシウム/カルモデュリン依存性プロテインキナーゼIIの活性低下が関与する (2009)
  • Author(s): 森口茂樹、韓峰、塩田倫史、喜多紗斗美、小室一成、岩本隆宏、福永浩司(口演)
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 可溶性Fas-ligandは脳虚血における神経細胞死に関与する (2009)
  • Author(s): 塩田倫史、福永浩司(口演)
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館
• [Presentation] フェニレフリンによる心筋障害における内皮型NOSの病態生理学的役割 (2009)
  • Author(s): 福永浩司、Ying-Mei LU、塩田倫史
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館
• [Presentation] ドネペジルによるマウス中隔野アセチルコリン神経保護作用 (2009)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司(学生シンポジウム)
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Na+/Ca2+交換体(NCX)による神経細胞内カルシウムと認知機能調節 (2008)
  • Author(s): 森口茂樹、韓峰、塩田倫史、喜多紗斗美、小室一成、岩本隆宏、福永浩司
  • Organizer: トランスポーターワークショップIN福岡
  • Place of Presentation: 福岡
  • Year and Date: 2008-11-02
• [Presentation] (2008)
  • Author(s): 塩田倫史、所崇、別府秀幸、北島勲、福永浩司
  • Organizer: 第47回日本薬学会東北支部大会
  • Place of Presentation: 岩手医科大学薬学部
  • Year and Date: 2008-10-26
• [Presentation] 精神遅滞関連遺伝子ATRX変異マウスのスパイン形成異常とそのメカニズム (2008)
  • Author(s): 塩田倫史、所崇、別府秀幸、北島勲、福永浩司(口演)
  • Organizer: 第47回日本薬学会東北支部大会
  • Place of Presentation: 岩手医科大学薬学部
  • Year and Date: 2008-10-26
• [Presentation] 嗅球摘出マウスにおけるDonepezilによるアセチルコリン神経保護作用 (2008)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司(口演)
  • Organizer: 第47回日本薬学会東北支部大会
  • Place of Presentation: 岩手医科大学薬学部
  • Year and Date: 2008-10-26
• [Presentation] (2008)
  • Author(s): 塩田倫史,福永浩司
  • Organizer: 第59回日本薬理学会北部会
  • Place of Presentation: 仙台市情報・産業プラザ
  • Year and Date: 2008-09-27
• [Presentation] 脳虚血におけるsoluble Fas-ligand発現と神経細胞死 (2008)
  • Author(s): 塩田倫史, 福永浩司(口演)
  • Organizer: 第59回日本薬理学会北部会
  • Place of Presentation: 仙台市情報・産業プラザ
  • Year and Date: 2008-09-27
• [Presentation] 嗅球摘出マウスにおけるドネペジルによるアセチルコリン神経保護作用 (2008)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司(口演)
  • Organizer: 第59回日本薬理学会北部会
  • Place of Presentation: 仙台市情報・産業プラザ
  • Year and Date: 2008-09-27
• [Presentation] (2008)
  • Author(s): 塩田倫史、所崇、別府秀幸、北島勲、福永浩司
  • Organizer: 日本生化学会東北支部第74回例会・シンポジウム
  • Place of Presentation: アイーナ 岩手県民情報交流センター
  • Year and Date: 2008-05-17
• [Presentation] クロマチンリモデリング蛋白質ATRX変異マウスのスパイン形成異常とそのメカニズム (2008)
  • Author(s): 塩田倫史、所崇、別府秀幸、北島勲、福永浩司(口演)
  • Organizer: 日本生化学会東北支部第74回例会・シンポジウム
  • Place of Presentation: アイーナ岩手県民情報交流センター
  • Year and Date: 2008-05-17
• [Presentation] 高次脳機能における心臓型脂肪酸結合蛋白質(H-FABP)の役割 (2008)
  • Author(s): 本橋慧樹、橋本茜、塩田倫史、近藤尚武、大和田祐二、福永浩司(シンポジウム)
  • Organizer: 日本薬学会 第128年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-26
• [Presentation] 嗅球摘出マウスにおける神経新生低下とうつ症状発現の経時的変化 (2008)
  • Author(s): 橋本 茜、韓 峰、塩田倫史、福永浩司(口演)
  • Organizer: 第17回神経行動薬理若手研究者の集い
  • Place of Presentation: 横浜情報文化センター
  • Year and Date: 2008-03-16
• [Presentation] 認知機能改善薬ZSET1446の海馬歯状回における神経新生促進効果とそのメカニズム (2008)
  • Author(s): 塩田倫史、韓 峰、山本由似、森口茂樹、山口芳正、日野正孝、福永浩司(口演)
  • Organizer: 第17回神経行動薬理若手研究者の集い
  • Place of Presentation: 横浜情報文化センター
  • Year and Date: 2008-03-16
• [Presentation] (2008)
  • Author(s): 塩田倫史,福永浩司
  • Organizer: 第20回日本脳循環代謝学会総会
  • Place of Presentation: 東京ドームホテル
• [Presentation] (2008)
  • Author(s): Norifumi Shioda, Takashi Tokoro, Hideyuki Beppu, Isao Kitajima and Kohji Fukunaga
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山国際会議場
• [Presentation] (2008)
  • Author(s): 塩田倫史、福永 浩司
  • Organizer: 第19回霧島神経薬理フォーラム
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• [Presentation] (2008)
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  • Organizer: 第31回日本神経科学大会
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• [Presentation] 脳虚血に伴うCaMKII活性低下は学習記憶障害に関与している (2008)
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• [Presentation] Activation of CaMKII mediates abnormal dendritic spine formation viaRacl-GEF/PAK signaling in ATRX mutant mouse brain (2008)
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  • Place of Presentation: Chicago USA
• [Presentation] The vanadium (IV) compound ameliorates OBX-induced neurodegenerati on of the septo-hippocampal cholinergic neurons through Akt and ERK nathways (2008)
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• [Presentation] Potentiation of calciumicalmoclulin-dependent protein kinase II benefits for cognitive enhancement in Alzheimer's disease patients (2008)
  • Author(s): Shigeki Moriguchi, Feng Han, Norifumi Shioda, Toshio Narahashi and Kohii Fukunaga
  • Organizer: International Conference on Alzheimer's Disease
  • Place of Presentation: Chicago USA
• [Presentation] Fas/Fas-ligandのアポトーシスシグナル伝達は脳虚血による神経細胞死に関与する (2008)
  • Author(s): 塩田倫史、福永浩司(口演)
  • Organizer: 第19回霧島神経薬理フォーラム
  • Place of Presentation: 日本文理大学湯布院研修所
• [Presentation] アルツハイマー治療薬ドネペジルはアセチルコリン神経保護作用を有する (2008)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司(口演)
  • Organizer: 第19回霧島神経薬理フォーラム
  • Place of Presentation: 日本文理大学湯布院研修所
• [Presentation] Abnormal dendritic spine formation via CaMKII/Racl-GEF/PAK signaling in X-linked mental retardation model mouse (2008)
  • Author(s): Norifumi Shioda, Takashi Tokoro, Hideynki Beppu,Isao Ritajim a2 and Kohji Fukunaga
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山国際会議場
• [Presentation] A novel cognitive enhancer, ZSET1446 improves olfactory bulbectomy inuced memory impairment through CaMKII and PKC activation in mouse hippocampus (2008)
  • Author(s): Yui yamamoto, Feng Han, Norifunki Shioda, Shigeki Moriguchi Kohil Fukunaga(Poster)
  • Organizer: XI Workshop on Apoptosis in Biology and Medicine
  • Place of Presentation: Tohoku Pharmaceutical University
• [Presentation] マウス中大脳動脈閉塞虚血におけるsoluble Fas ligahdと神経細胞死 (2008)
  • Author(s): 塩田倫史, 福永浩司
  • Organizer: 第20回日本脳循環代謝学会総会
  • Place of Presentation: 東京ドームホテル
• [Presentation] CaMKIIの活性異常は精神遅滞モデルマウスにおけるスパイン形態異常に関与する (2008)
  • Author(s): 塩田倫史、別府秀幸、北島勲、福永浩司(口演)
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 心臓型脂肪酸結合蛋白質欠損マウスの神経薬理学的表現型 (2008)
  • Author(s): 山本由似、本橋慧樹、塩田倫史、大和田祐二、福永浩司(口演)
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] ZSET1446はCaMKIIとPKCを活性化して嗅球除去マウスの記憶障害を改善する (2008)
  • Author(s): 韓 峰、塩田倫史、森口茂樹、山口芳正、日野正孝、福永浩司(口演)
  • Organizer: 第81回 日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 認知機能改善薬ZSET1446は嗅球摘出マウスにおける海馬の神経新生を促進してうつ症状を改善する (2008)
  • Author(s): 塩田倫史、韓 峰、森口茂樹、山口芳正、日野正孝、福永浩司(口演)
  • Organizer: 第81回 日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Impairments of Akt and eNOS signalings by pressure overload aggravates isoproterenol-induced heart failure in ovariectomized female rats. (2008)
  • Author(s): Md. Shenuarin Bhuiyan, Norifumi Shioda and Kohji Fukunaga(口演)
  • Organizer: 第81回 日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] フェニレフリン誘導による心筋障害に対してDY-9836は活性酸素産生とカベオリン3の分解を抑制して心筋細胞を保護する (2008)
  • Author(s): Ying Mei Lu、塩田倫史、白崎康文福永浩司(口演)
  • Organizer: 第81回 日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 脳虚血におけるFasリガンドの誘導と神経細胞死 (2008)
  • Author(s): 塩田倫史、福永浩司(口演)
  • Organizer: 日本薬学会 第128年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 高次脳機能における心臓型脂肪酸結合蛋白質(H-FABP)の役割 (2007)
  • Author(s): 本橋慧樹、橋本茜、塩田倫史、近藤尚武、大和田祐二、福永浩司(口演)
  • Organizer: 第60回日本薬理学会西南部会
  • Place of Presentation: 宮崎県 宮崎市
  • Year and Date: 2007-11-22
• [Presentation] 4価バナジウム化合物VO(OPT)は脳虚血における神経新生を促進する。 (2007)
  • Author(s): 塩田倫史、澁谷正俊、岩渕好治、福永浩司(口演)
  • Organizer: 第46回日本薬学会東北支部大会
  • Place of Presentation: 東北薬科大学
  • Year and Date: 2007-10-28
• [Presentation] マウス両総頸動脈結紮モデルにおけるnobiletinの神経保護作用 (2007)
  • Author(s): 山本由似、塩田倫史、中島晶、山國徹、大泉康、福永浩司(口演)
  • Organizer: 第46回日本薬学会東北支部大会
  • Place of Presentation: 東北薬科大学
  • Year and Date: 2007-10-28
• [Presentation] マウス中大脳動脈閉塞ペナンブラ領域におけるFas ligandの発現機序 (2007)
  • Author(s): 塩田倫史、福永浩司(口演)
  • Organizer: 第58回日本薬理学会北部会
  • Place of Presentation: 北海道 札幌市
  • Year and Date: 2007-09-29
• [Presentation] アセチルコリンと神経新生 (2007)
  • Author(s): 塩田倫史(口演)
  • Organizer: 生体情報と創薬フォーラム/国際高等融合領域研究所セミナー
  • Place of Presentation: 東北大学薬学研究科
  • Year and Date: 2007-09-26
• [Presentation] 中枢神経系における脂肪酸の機能制御因子としての心臓型脂肪酸結合タンパク質(H-FABP) (2007)
  • Author(s): 本橋慧樹、橋本茜、塩田倫史、近藤尚武、大和田祐二、福永浩司(口演)
  • Organizer: 第18回霧島神経薬理フォーラム
  • Place of Presentation: 見奈良天然温泉 利楽
  • Year and Date: 2007-08-25
• [Presentation] A NOVEL STIMULANT OF NEUROGENESIS FOLLOWING MOUSE BRAIN ISCHEMIA VIAPI3K/AKT AND ERK ACTIVATION IN THE SUBGRANULAR ZONE OF HIPPOCAMPUS (2007)
  • Author(s): Norifumi Shioda and Kohji Fukunaga (Poster)
  • Organizer: BRAIN'07&BRAINPET'07
  • Place of Presentation: 大阪国際会議場(グランキューブ大阪)(大阪)
• [Presentation] NefiracetamによるNMDA受容体賦活作用はprotein kinase Cを介する (2007)
  • Author(s): 森口茂樹、塩田倫史、楢橋敏夫、福永浩司(口演)
  • Organizer: 第30回 日本神経科学大会 第50回 日本神経化学会大会第17回 日本神経回路学会大会(Neuro2007)
  • Place of Presentation: パシフィコ横浜
• [Presentation] 新規バナジウム化合物はAktとERKを介して脳虚血後の海馬歯状回における神経新生を亢進する。 (2007)
  • Author(s): 塩田倫史、福永浩司(poster)
  • Organizer: 第30回 日本神経科学大会 第50回 日本神経化学会大会第17回 日本神経回路学会大会(Neuro2007)
  • Place of Presentation: パシフィコ横浜
• [Presentation] Chronic treatment of methylphenidate injures behavioral/cognitive functions by degeneration of dopaminergic neuron in rats. (2007)
  • Author(s): Sara Wardhani, Shioda Norifumi, Kohji Fukunaga (poster)
  • Organizer: 第30回 日本神経科学大会 第50回 日本神経化学会大会第17回 日本神経回路学会大会(Neuro2007)
  • Place of Presentation: パシフィコ横浜
• [Presentation] 認知機能改善薬ZSET1446は嗅球摘出マウスの海馬歯状回における神経新生を促進し、うつ症状を改善する (2007)
  • Author(s): 塩田倫史、韓峰、森口茂樹、山口芳正、日野正孝、福永浩司(poster)
  • Organizer: 生体機能と創薬シンポジウム2007
  • Place of Presentation: 金沢
• [Presentation] 若年ラットにおけるメチルフェニデート慢性投与によるドパミン神経障害と認知機能障害 (2007)
  • Author(s): Sara Wardhani, 塩田倫史、福永浩司(poster)
  • Organizer: 生体機能と創薬シンポジウム2007
  • Place of Presentation: 金沢
• [Presentation] マウス中大脳動脈閉塞モデルにおけるFas ligand の発現と神経細胞死 (2007)
  • Author(s): 塩田倫史、福永浩司(口演)
  • Organizer: 第19回日本脳循環代謝学会総会
  • Place of Presentation: ホテルメトロポリタン盛岡NEW WING
• [Presentation] The chromatin-remodeling gene ATRX mutant mice exhibit abnormal behaviors and learning impairment related to ADHD. (2007)
  • Author(s): T Tokoro, H Beppu, S Moriguchi, N Shioda, K Fukunaga, H Nishijo, I Kitajima and E Li(poster)
  • Organizer: 37th. Society for Neuroscience; Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Effects of a novel cognitive enhancer, ZSETI446 on depressive behavior and neurogenesis in the dentate gyrus of olfactory bulbectomized mice. (2007)
  • Author(s): Y Yamaguchi, N Shioda, F Han, S Moriguchi, M Hino and K Fukunaga(poster)
  • Organizer: 37th. Society for Neuroscience; Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Impairment of CaM kinase II underlies memory deficits and depressive behaviors in the olfactory bulbectomized mice. (2007)
  • Author(s): F Han, T Nakano, N Shioda, S Moriguchi, M Morioka and K Fukunaga(poster)
  • Organizer: 37th. Society for Neuroscience; Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] The vanadyl compound enhances proliferation and migration of new neurons following brain ischemia through PI3K/Akt and ERK pathways. (2007)
  • Author(s): Kohji Fukunaga and Norifumi Shioda (poster)
  • Organizer: 37th. Society for Neuroscience; Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Activation of CaM kinase II is implicated in generation of abnormal dendritic spines via Tiam1/PAK signaling in ATRX mutant mouse brain. (2007)
  • Author(s): Norifumi Shioda, Takashi Tokoro, Isao Kitajima, Hideyuki Beppu and Kohji Fukunaga(poster)
  • Organizer: 37th. Society for Neuroscience; Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Pathological relevance of impaired Akt and eNOS signalings in cardiac hypertrophy in ovariectomized female rats. (2007)
  • Author(s): Md. Shenuarin Bhuiyan, Norifumi Shioda, Kohji Fukunaga(口演)
  • Organizer: The 7th Japan-Korea joint symposium of brain sciences, and cardiac and smooth muscles
  • Place of Presentation: Sendai