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Physical and functional interaction between WRNIP1 and RAD18

Research Project

Project/Area Number 19790046
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionTohoku University

Principal Investigator

YOSHIMURA Akari  Tohoku University, 大学院・薬学研究科, 助手 (70302164)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,450,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsDNA修復 / WRNIP1 / RAD18 / ウェルナー症候群 / CPT
Research Abstract

本研究では、早老症ウェルナー症候群原因遺伝子産物WRNと相互作用するタンパク質として申請者の所属する研究室で見出されたWRNIP1の機能解析を目的とした。申請者は、損傷トレランス機構で働くRAD18とWRNIP1が相互作用することを初めて見出した。そこで、その機能的連携の解析から、WRNIP1が損傷トレランス機構の中心で働くRAD18と連携をとりながら、損傷トレランス機構に関与することが示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (24 results)

All 2009 2008 2007 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (7 results)

  • [Journal Article] Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD22009

    • Author(s)
      Takada S, Inoue E, Tano K, Yoshii H, Abe T, Yoshimura A, Akita M, Tada S, Watanabe M, Seki M, Enomoto T
    • Journal Title

      Biochem Biophys Res Commun 379

      Pages: 233-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physical and functional interaction between WRNIP1 and RAD182009

    • Author(s)
      Akari Yoshimura, et.al.
    • Journal Title

      Genes Genet. Syst (印刷中)

    • NAID

      10024791852

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel role for Rad17 in homologous recombination2008

    • Author(s)
      Nishino K, Inoue E, Takada S, Abe T, Akita M, Yoshimura A, Tada S, Kobayashi M, Yamamoto K, Seki M, Enomoto T
    • Journal Title

      Genes Genet Syst 83

      Pages: 427-31

    • NAID

      10023888077

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation2008

    • Author(s)
      Abe T, Ishiai M, Hosono Y, Yoshimura A, Tada S, Adachi N, Koyama H, Takata M, Takeda S, Enomoto T, Seki M.
    • Journal Title

      Cell Signal 20

      Pages: 1978-85

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability2008

    • Author(s)
      Hayashi T, Seki M, Inoue E, Yoshimura A, Kusa Y, Tada S, Enomoto T
    • Journal Title

      Genes Genet Syst 83

      Pages: 95-100

    • NAID

      10024395708

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase IIIalpha2008

    • Author(s)
      Otsuki M, Seki M, Inoue E, Abe T, Narita Y, Yoshimura A, Tada S, Ishii Y, Enomoto T
    • Journal Title

      Biochim Biophys Acta 1782

      Pages: 75-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel role for Rad17 in homologous recombination2008

    • Author(s)
      Katsuaki Nisnino, et.al.
    • Journal Title

      Genes Genet. Syst 83

      Pages: 233-238

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD22008

    • Author(s)
      Syunya Takada, et.al.
    • Journal Title

      Biochem. Biophys. Res. Commun 379

      Pages: 233-238

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ku70/80, DNA-PKcs, and Artemis, are essential for the rapid induction of apoptosis after massive DSB formation2008

    • Author(s)
      Takuya Abe, et.al.
    • Journal Title

      Cell Signal 20

      Pages: 1978-1985

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability2008

    • Author(s)
      Hayashi T., et. al.
    • Journal Title

      Genes Genet Syst. 83

      Pages: 95-100

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional interactions between BLM and XRCC3 in the cell2007

    • Author(s)
      Otsuki M, Seki M, Inoue E, Yoshimura A, Kato G, Yamanouchi S, Kawabe Y, Tada S, Shinohara A, Komura J, Ono T, Takeda S, Ishii Y, Enomoto T
    • Journal Title

      J Cell Biol 179(1)

      Pages: 53-63

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] WRN functions in a RAD18-dependent damage avoidance pathway2007

    • Author(s)
      Dong YP, Seki M, Yoshimura A, Inoue E, Furukawa S, Tada S, Enomoto T
    • Journal Title

      Biol Pharm Bull 30

      Pages: 1080-3

    • NAID

      110006278395

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] WRN counteracts the NHEJ pathway upon camptothecin exposure2007

    • Author(s)
      Otsuki M, Seki M, Kawabe Y, Inoue E, Dong YP, Abe T, Kato G, Yoshimura A, Tada S, Enomoto T
    • Journal Title

      Biochem Biophys Res Commun 355

      Pages: 477-82

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase III alpha2007

    • Author(s)
      Otsuki M., et. al.
    • Journal Title

      Biochim Biophys Acta 1782

      Pages: 75-81

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional interaction between BLM and XRCC3 in the cell2007

    • Author(s)
      Otsuki M., et. al.
    • Journal Title

      J Cell Biol. 179

      Pages: 53-63

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WRN functions in a RAD 18-dependent damage avoidance pathway2007

    • Author(s)
      Dong YP, et. al.
    • Journal Title

      Biol Pharm Bull. 30

      Pages: 1080-1083

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physical and functional interaction between WRNIP1 and RAD18

    • Author(s)
      Yoshimura A, Seki M, Kanamori M, Tateishi S, Tsurimoto T, Tada S, Enomoto T
    • Journal Title

      Genes Genet Syst (in press)

    • NAID

      10024791852

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] WRNIP1のRAD180RAD6複合体への結合と複合体のDNA結合に及ぼす影響2009

    • Author(s)
      吉村明
    • Organizer
      日本薬学会 第129年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] WRNIP1のRAD18-RAD6複合体への結合と複合体のDNA結合に及ぼす影響2009

    • Author(s)
      吉村明
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館グランドプリンスホテル京都
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] WRNIP1はRAD18-RAD6に結合し、RAD18-RAD6のもつ複製フォーク様構造への結合を阻害する2008

    • Author(s)
      吉村明
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] WRNIP1はRAD18-RAD6に結合し、RAD18-RAD6のもつ複製フォーク様構造への結合を阻害する2008

    • Author(s)
      吉村明
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニワトリDT40細胞を用いた抗酸化酵素遺伝子破壊株の解析2007

    • Author(s)
      井上 絵里, 他
    • Organizer
      第30回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] WRNIP1とRAD18の機能的連携の解明2007

    • Author(s)
      吉村明
    • Organizer
      第30回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-13
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 抗酸化酵素SOD2の転写on/off株の構築とその解析2007

    • Author(s)
      高田 隼也, 他
    • Organizer
      第46回日本薬学会東北支部大会
    • Place of Presentation
      東北薬科大学
    • Year and Date
      2007-10-28
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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