Identification of cutaneous serine proteinases related the induction of itch in atopic dermatitis and the mechanisms of itch
| Project/Area Number |
19790051
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
ANDOH Tsugunobu University of Toyama, 大学院・医学薬学研究部(薬学), 准教授 (50333498)
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| Research Collaborator |
TSUJII Kenichiro 富山大学, 大学院・医学薬学研究部(薬学)・応用薬理学
NAKANO Tasuku 富山大学, 大学院・医学薬学研究部(薬学)・応用薬理学
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,730,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | かゆみ / プロテアーゼ / アトピー性皮膚炎 / 皮膚 / マスト細胞 / PAR-2 / 一次感覚神経 / 痒み / アスパラギン酸プロテアーゼ / セリンプロテアーゼ / マウス / T細胞 / カリクレイン |
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| Research Abstract |
In addition to the involvement of proteinases on the induction of itch in atopic dermatitis, the mechanisms were also investigated. This study demonstrated that serine proteinases, such as tryptase, and proteinase-activated receptor-2 (PAR_2) played an important role on the induction of itch in atopic dermatitis. In addition to keratinocytes, PAR_2 is expressed on primary afferents. Thus, PAR_2-expressed primary afferent is important on the transmission of itch in atopic dermatitis.
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Report
(4 results)
Research Products
(33 results)
