Functional analysis of RPEL/Phactr variants: relationship between cell shape and nuclear information
| Project/Area Number |
19790052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
TABUCHI Akiko University of Toyama, 大学院医学薬学研究部(薬学), 准教授 (40303234)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | serum response factor / megakaryoblastic leukemia / phactr / siRNA / transcription factor / 大脳皮質ニューロン / megakarvoblastic leukemia / Phactr |
|---|
| Research Abstract |
神経突起などの「かたち」の変化は、記憶学習の基盤と考えられている。申請者らは、「かたち」をコントロールするアクチン細胞骨格に結合する性質と、遺伝子を制御する性質の両方を持つ分子群[megakaryoblastic leukemia (MKL)とPhactr]に焦点を当てた研究を行った。神経細胞は、樹状突起と軸索という特徴的なかたちを持っているが、本研究結果から、MKLは主に樹状突起形態を、Phactrは軸索形態をコントロールしている可能性が示唆された。
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Extracellular adenosine 5'-triphosphate elicits the expression of brain-derived neurotrophic factor exon IV mRNA in rat astrocytes2008
Author(s)
Takasaki, I., Takarada, S., Tatsumi, S., Azegami, A., Yasuda, M., Fukuchi, M., Tabuchi, A., Kondo, T., Tabuchi, Y. and Tsuda, M.
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Journal Title
Related Report
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[Journal Article] Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanisms2007
Author(s)
Yasuda, M., Fukuchi, M., Tabuchi, A., Kawahara, M., Tsuneki, H., Azuma, Y., Chiba, Y. and Tsuda, M.
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Journal Title
J. Neurochem. 103
Pages: 626-636
Related Report
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[Journal Article] Regulation of neurotrophin-3 gene transcription by Sp3 annd Sp4 in neurons2007
Author(s)
Ishimaru, N., Tabuchi, A., Hara, D., Hayashi, H., Sugimoto, T., Yasuhara, M., Shiota, J. and Tsuda, M.
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Journal Title
J. Neurochem. 100
Pages: 520-531
Related Report
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