The roles of Fgf19 in development of GABAergic interneurons and dopaminergic neurons

• Project/Area Number: 19790057
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: MIYAKE Ayumi Kyoto University, 薬学研究科, 講師 (40346044)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: FGF / ゼブラフィッシュ / 脳・神経形成 / 眼形成 / 脳・神経 / GABA作動性ニューロン / ドパミン作動性ニューロン / 網膜 / 前脳

Research Abstract

Fgf19シグナルはFgf受容体1とFgf受容体4を介してMAPK経路を活性化することにより網膜の前後軸の特性決定を調節していることが明らかになった。また、終脳の形成過程におけるFgf19の機能はFgf受容体1あるいはFgf受容体2を介して発揮され、間脳の形成過程におけるFgf19の機能はFgf受容体1、Fgf受容体2あるいはFgf受容体4を介して発揮される可能性が示唆された。

Research Products

• [Journal Article] Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish (2009)
  • Author(s): S. Mizumoto, T. Mikami, D. Yasunaga, N. Kobayashi, H. Yamauchi, A. Miyake, N. Itoh, H. Kitagawa, K. Sugahara
  • Journal Title: Biochem. J. 419 Pages: 387-399
  • Peer Reviewed
• [Journal Article] Fgf19 is required for zebrafish lens and retina development (2008)
  • Author(s): Y. Nakayama, A. Miyake, Y. Nakagawa, T. Mido, M. Yoshikawa, M. Konishi, N. Itoh
  • Journal Title: Dev. Biol. 313 Pages: 752-756
  • Peer Reviewed
• [Journal Article] Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain (2008)
  • Author(s): I. Kimura, Y. Nakayama, H. Yamauchi, M. Konishi, A. Miyake, M. Mori, M. Ohta, N. Itoh, M. Fujimoto
  • Journal Title: J. Biol. Chem. 238 Pages: 4323-4331
  • Peer Reviewed
• [Journal Article] Neurotrophic activity of neudesin. a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain (2008)
  • Author(s): I. Kimura, Y. Nakayama, H. Yamauchi, M. Konishi, A. Miyake, M. Mori, M. Ohta, N. Itoh, M. Fujimoto
  • Journal Title: J. Biol. Chem. 238 Pages: 4323-4331
  • Peer Reviewed
• [Journal Article] fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish (2007)
  • Author(s): T. Wakahara, N. Kusu, H.Yamauchi, I. Kimura, M. Konishi, A. Miyake, N. Itoh
  • Journal Title: Dev. Biol. 303 Pages: 527-535
  • Peer Reviewed
• [Journal Article] fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish (2007)
  • Author(s): T. Wakahara, N. Kusu, H. Yamauchi, I. Kimura, M. Konishi, A. Miyake, N. Itoh
  • Journal Title: Dev. Biol. 303 Pages: 527-535
  • Peer Reviewed
• [Presentation] Fgf19 is required for zebrafish lens and retina development (2008)
  • Author(s): A. Miyake, N. Itoh
  • Organizer: The XVIII International Congress for Eye Research
  • Place of Presentation: Beijing, China
  • Year and Date: 2008-09-27
• [Presentation] Fgfl9 is required for zebrafish lens and retina development (2008)
  • Author(s): A. Miyake, N. Itoh
  • Organizer: The XVIII International Congress for Eye Research
  • Place of Presentation: Beijing, China
  • Year and Date: 2008-09-27