Identification and characterization of genes involved in endoplasmic reticulum-associated degradation
| Project/Area Number |
19790070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
MASAYUKI Kaneko Chiba Institute of Science, 薬学部, 講師 (10322827)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 小胞体ストレス / ERAD / アルツハイマー病 / ユビキチンリガーゼ / APP / 小細胞 / ニューロン / 神経変性疾患 / 小胞体 / バイオインフォマティクス / アポトーシス |
|---|
| Research Abstract |
HRD1の発現抑制は,APPとAβの増加をもたらすとともに,小胞体ストレスと神経細胞死を誘発することを示めし,AD患者の大脳皮質において,HRD1タンパク質が低下していることを明らかにした.さらに,APPの分解に関与する新規エビキチンリガーゼも新たに見出した.また,小胞体ストレス応答転写因子ATF6とXBP1がAPPの分解を促進し,Aβの産生を減少させることを明らかにした.さらに,HRD1やSEL1, Kf-1を含むERAD分子は,脳神経細胞に発現していることを示した.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Novel functions of ubiquitin ligase HRD1 with transmembrane and proline-rich domains2008
Author(s)
Omura, T., Kaneko, M., Onoguchi, M., Koizumi, S., Itami, M., Ueyama, M., Okuma, Y., Nomura, Y.
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Journal Title
J. Pharmacol. Sci. 106
Pages: 512-519
NAID
Related Report
Peer Reviewed
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[Journal Article] A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes2007
Author(s)
Kaneko, M., Yasui, S., Niinuma, Y., Arai, K., Omura, T., Okuma, Y., Nomura, Y.
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Journal Title
FEBS Lett. 581
Pages: 5355-5360
NAID
Related Report
Peer Reviewed
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[Journal Article] Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation
Author(s)
Kaneko, M., Koike, H., Saito, R., Kitamura, Y., Okuma, Y., Nomura, Y.
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Suppression of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and b-amyloid generation with endoplasmic reticulum stress and apoptosis2008
Author(s)
Kaneko, M., Koike, H., Omura, T., Okuma, Y., Nomura, Y.
Organizer
Neuroscience 2008
Place of Presentation
Washington, DC
Related Report
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