| Budget Amount *help |
¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Research Abstract |
During hemodialysis, the contact of blood components with artificial hemodialysis membranes induce the activation of leukocytes and production of reactive oxygen species (ROS), followed with development of long-term dialysis related complications. In this study, I revealed the mechanism of leukocyte activation induced by hemodialysis membranes, i.e. the contact of blood with hemodialysis membrane evokes expression of P-selectin on activated platelets, formation of platelet-neutrophil microaggregates and production of ROS by neutrophils. The contact of plasma with hemodialysis membrane also activates complement system and induces formation of anaphylatoxin C5a and cap formation of P-selectin ligand on neutrophils which enhances formation of the microaggregates. I found alpha-tocopherol and glycyrrhizin could prevent the interaction of platelets and neutrophils and activation of neutrophils during hemodialysis.
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