Prevention of long term dialysis related complications induced by crosstalk among blood cells
| Project/Area Number |
19790075
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Nagoya City University (2008-2009)
Hoshi University (2007) |
|---|
Principal Investigator |
ITOH Saotmo Nagoya City University, 大学院・薬学研究科, 助教 (70308013)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Keywords | 細胞生物学 / 血液透析 / 血液細胞間クロストーク / 細胞接着分子 / P-セレクチン |
|---|
| Research Abstract |
During hemodialysis, the contact of blood components with artificial hemodialysis membranes induce the activation of leukocytes and production of reactive oxygen species (ROS), followed with development of long-term dialysis related complications. In this study, I revealed the mechanism of leukocyte activation induced by hemodialysis membranes, i.e. the contact of blood with hemodialysis membrane evokes expression of P-selectin on activated platelets, formation of platelet-neutrophil microaggregates and production of ROS by neutrophils. The contact of plasma with hemodialysis membrane also activates complement system and induces formation of anaphylatoxin C5a and cap formation of P-selectin ligand on neutrophils which enhances formation of the microaggregates. I found alpha-tocopherol and glycyrrhizin could prevent the interaction of platelets and neutrophils and activation of neutrophils during hemodialysis.
|
Report
(4 results)
Research Products
(24 results)
