Development of negative signal-inducing anti-allergic IgE
Project/Area Number |
19790084
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
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Research Institution | National Institute of Health Sciences |
Principal Investigator |
NAKAMURA Ryosuke National Institute of Health Sciences, 代謝生化学部, 主任研究官 (50333357)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
Keywords | 免疫化学 / 抗アレルギー薬 / IgE / マスト細胞 / シグナル伝達 / アレルギー試験 |
Research Abstract |
Mast cells play important roles in the allergic reactions, and they express active signal-inducing high-affinity IgE receptors (FcεRI) and negative signal-inducing low-affinity IgG receptors (FcγRIIB) on their surface. In this study, new IgE molecule which may bind FcεRI and FcγRIIB simultaneously was genetically developed.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Effects of developmental hypothyroidism induced by maternal administration of methimazole or propylthiouracil on the immune system of rats2008
Author(s)
Nakamura, R., Teshima, R., Hachisuka, A., Sato, Y., Takagi, K., Nakamura, R., Woo, G. H., Shibutani, M., Sawada, J.
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Journal Title
International Immunopharmacology 7
Pages: 1630-1638
Related Report
Peer Reviewed
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[Journal Article] Effect of perinatal exposure to the flame-retardant tetrabromobisphenol A on the developing immune system of rats2008
Author(s)
Nakamura, R., Hachisuka, A., Sato, Y., Nakamura, R., Shibutani, M., Sawada, J., Teshima, R.
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Journal Title
Bulletin of National Institute of Health Sciences 126
Pages: 65-70
NAID
Related Report
Peer Reviewed
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[Journal Article] Effect of exposure to decabromodiphenylether on the development of the immune system in rats2008
Author(s)
Teshima, R., Nakamura, R., Nakamura, R., Hachisuka, A., Sawada, J., Shibutani, M.
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Journal Title
Journal of Health Science 54
Pages: 382-389
Related Report
Peer Reviewed
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[Journal Article] Effects of developmental hypothyroidism induced by maternal administration of methimazole or propylthiouracil on the immune system of rats2007
Author(s)
Nakamura, R., Teshima, R., Hachisuka, A., Sato, Y., Takagi, K., Nakamura, R., Woo, G.H., Shibutani, M., Sawada, J.
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Journal Title
International Immunopharmacology Vol.7、No.13
Pages: 1630-1638
Related Report
Peer Reviewed
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