In silico and HTS screenings of oligosaccharide processing enzyme as drug discovery target
| Project/Area Number |
19790102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
HAKAMATA Wataru Nihon University, 生物資源科学部, 講師 (10333337)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,860,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | 糖鎖 / ウイルス / 酵素反応 / 小胞体 / 翻訳後修飾 / in silico / スクリーニング / 翻訳後修 |
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| Research Abstract |
For the development of a true alpha-inhibitor that acts in cells, in silico HTS using the target alpha-glucosidase and computer-aided inhibitors for screening based on enzymological information of alpha-glucosidase are important.
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Report
(4 results)
Research Products
(9 results)
