The effects of estrogenic chemicals on epigenetics.

• Project/Area Number: 19790109
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental pharmacy
• Research Institution: Nigata University of Phermacy and Applied Life Sciences
• Principal Investigator: SATO Koji Nigata University of Phermacy and Applied Life Sciences, 薬学部, 助教 (10445893)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 遺伝子 / ゲノム / 環境 / 衛生 / 発現制御 / エピジェネティクス / DNAメチル化 / エストロゲン / 女性ホルモン / 化学物質

Research Abstract

環境中の化学物質や、食品中の成分、薬剤の中にはエストロゲンなどのヒトが持つホルモンと構造が似たものがあり、それらを摂取することによって正常なホルモンの働きに悪影響が起こることが懸念されている。本研究では、培養細胞にエストロゲン様の化学物質を加えてその影響を調べたところ、DNAメチル化を担う遺伝子の発現が変化したことから、エピジェネティクスという遺伝子発現の調節機構に影響が起こることが示唆された。

Research Products

• [Journal Article] Neonatal exposure to diethylstilbestrol alters expression of DNA methyltransferases and methylation of genomic DNA in the mouseuterus. (2009)
  • Author(s): Sato K, Fukata H, Kogo Y, Ohgane J, Shiota K, Mori C
  • Journal Title: Endocrine Journal 56 Pages: 131-139
  • Peer Reviewed
• [Journal Article] Neonatal exposure to diethylstilbestrol alters expression of DNA methyltransferases and methylation of genomic DNA in the mouse uterus (2009)
  • Author(s): Sato K, Fukata H, Kogo Y, Ohgane J, Shiota K, Mori C
  • Journal Title: Endocrine Journal 56 Pages: 131-139
  • NAID: 10025610481
  • Peer Reviewed
• [Journal Article] DNA methylation changes during cleft palate formation induced by retinoic acid in mice. (2008)
  • Author(s): Kuriyama M, Udagawa A, Yoshimoto S, Ichinose M, Sato K, Yamazaki K, Shiota K, Mori C
  • Journal Title: Cleft Palate-Craniofacial Journal 45 Pages: 545-551
  • Peer Reviewed
• [Journal Article] DNA methylation changes during cleft palate formation induced by retinoic acid in mice (2008)
  • Author(s): Kuriyama M, Udagawa A, Yoshimoto S, Ichinose M, Sato K, Yamazaki K, Shiota K, Mori C
  • Journal Title: Cleft Palate-Craniofacial Journal 45 Pages: 545-551
  • Peer Reviewed
• [Journal Article] Polychlorinated biphenyls (PCBs) alter the expression of endothelial nitric oxide synthase (eNOS) mRNA in human umbilical vein endothelial cells (HUVECs). (2007)
  • Author(s): Omori N, Fukata H, Sato K, Yamazaki K, Aida-Yasuoka K, Takigami H, Kuriyama M, Ichinose M, Mori C
  • Journal Title: Human & Experimental Toxicology 26 Pages: 811-816
  • Peer Reviewed
• [Journal Article] Polychlorinated biphenyls (PCBs) alter the expression of endothelial nitric oxide synthase (eNOS) mRNA in human umbilical vein endothelial cells (HUVECs). (2007)
  • Author(s): Omori N 他8名
  • Journal Title: Human & Experimental Toxicology 26 Pages: 811-816
  • Peer Reviewed
• [Presentation] ポリ臭素化ジフェニルエーテル(PBDEs)が酸化ストレスに関連する遺伝子発現に及ぼす影響 (2008)
  • Author(s): 川城由紀子、深田秀樹、佐藤浩二、油谷浩幸、滝上英孝、森千里
  • Organizer: 環境ホルモン学会第11回研究発表会
  • Place of Presentation: 東京
• [Presentation] ポリ臭素化ジフェニルエーテル(PBDEs)が酸化ストレスに関連する遺伝子発現に及ぼす影響 (2008)
  • Author(s): 川城由紀子、深田秀樹、佐藤浩二、油谷浩幸、滝上英孝、森千里
  • Organizer: 環境ホルモン学会第11回研究発表会
  • Place of Presentation: 東京(星陵会館)
• [Presentation] 臭素系難燃剤高濃度曝露がヒト臍帯静脈内皮細胞の遺伝子発現に及ぼす影響 (2007)
  • Author(s): 川城由紀子、深田秀樹、森可奈、佐藤浩二、滝上英孝、油谷浩幸、森千里
  • Organizer: 環境ホルモン学会第10回研究発表会
  • Place of Presentation: 埼玉
• [Presentation] Effects of the flame retardants, polybrominated diphenyl ethers, on human umbilical vein endothelial cells using DNA microarray analysis. (2007)
  • Author(s): Kawashiro Y, Fukata H, Sato K, Takigami H, Aburatani H, Mori C
  • Organizer: 27th International Symposium on Halogenated Persistent Organic Pollutants-DIOXIN 2007
  • Place of Presentation: Tokyo
• [Presentation] Effects of the flame retardants, polybrominated diphenyl ethers, on human umbilical vein endothelial cells using DNA microarray alalysis. (2007)
  • Author(s): Kawashiro Y 他5名
  • Organizer: 27th International Symposium on Halogenated Persistent Organic Pollutants-DIOXIN 2007
  • Place of Presentation: Tokyo
• [Presentation] 臭素系難燃剤高濃度曝露がヒト臍帯静脈内皮細胞の遺伝子発現に及ぼす影響 (2007)
  • Author(s): 川城由紀子 他6名
  • Organizer: 環境ホルモン学会 第10回研究発表会
  • Place of Presentation: 埼玉