Development of systemic delivery system for RNAi-based therapies
| Project/Area Number |
19790131
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
ASAI Tomohiro University of Shizuoka, 大学院・薬学研究科, 講師 (00381731)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | ドラッグデリバリー / RNA干渉 / siRNA / mTOR / がん / リボソーム / リポソーム |
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| Research Abstract |
RNA interference (RNAi)-based therapy with small interfering RNA (siRNA) is expected as a potent treatment strategy for intractable diseases. However, systemic injection of siRNA is quite limited because of a problem of DDS technology. In the present study, a novel siRNA delivery system was established to achieve RNAi-based cancer therapies. Our data demonstrated that systemic injection of therapeutic siRNAs using our DDS technology suppressed tumor growth in animal studies.
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Report
(4 results)
Research Products
(73 results)
