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Development of systemic delivery system for RNAi-based therapies

Research Project

Project/Area Number 19790131
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

ASAI Tomohiro  University of Shizuoka, 大学院・薬学研究科, 講師 (00381731)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsドラッグデリバリー / RNA干渉 / siRNA / mTOR / がん / リボソーム / リポソーム
Research Abstract

RNA interference (RNAi)-based therapy with small interfering RNA (siRNA) is expected as a potent treatment strategy for intractable diseases. However, systemic injection of siRNA is quite limited because of a problem of DDS technology. In the present study, a novel siRNA delivery system was established to achieve RNAi-based cancer therapies. Our data demonstrated that systemic injection of therapeutic siRNAs using our DDS technology suppressed tumor growth in animal studies.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (73 results)

All 2010 2009 2008 2007

All Journal Article (34 results) (of which Peer Reviewed: 31 results) Presentation (38 results) Book (1 results)

  • [Journal Article] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.2010

    • Author(s)
      Koide, H., Asai, T., Hatanaka, K., et al.
    • Journal Title

      Int. J. Pharm. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography.2010

    • Author(s)
      Hatanaka, K., Asai, T., Koide, H., et al.
    • Journal Title

      Bioconjug. Chem. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion.2010

    • Author(s)
      Ishii, T., Asai, T., Urakami, T., et al.
    • Journal Title

      Brain Res. 1321(in press)

      Pages: 164-168

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] novel DDS strategy, "dual-targeting", and its application for antineovascular therapy.2010

    • Author(s)
      Murase, Y., Asai, T., Katanasaka, Y., et al.
    • Journal Title

      Cancer Lett. 287

      Pages: 165-171

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PeGylated liposomes.2010

    • Author(s)
      Koide, H., et al.
    • Journal Title

      Int.J.Pharm. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of double-stranded siRNA labeling method using pwsitron emitter and its in vivo trfficking analyzed by positron emission tomography.2010

    • Author(s)
      Hatanaka, K., et al.
    • Journal Title

      Bioconjug.Chem. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78.2010

    • Author(s)
      Katanasaka, Y., et al.
    • Journal Title

      Int.J.Cancer. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion.2010

    • Author(s)
      Ishii, T., et al.
    • Journal Title

      Brain Res. 1321

      Pages: 164-168

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel DDS strategy,"dual-targeting", and its application for antineovascular therapy.2010

    • Author(s)
      Murase, Y., et al.
    • Journal Title

      Cancer Lett. 287

      Pages: 165-171

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane.2010

    • Author(s)
      Shimizu, K., et al.
    • Journal Title

      J.Control.Release 141

      Pages: 208-215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice.2010

    • Author(s)
      Shimizu, K., et al.
    • Journal Title

      Biol Pharm Bull. 33

      Pages: 117-121

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elucidation of accelerated blood clearance phenomenon caused by repeat injection of PEGylated nanocarriers.2010

    • Author(s)
      Koide, H., et al.
    • Journal Title

      Yakugaku Zasshi 129

      Pages: 117-121

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Evaluation of O-[(18)F] fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography.2009

    • Author(s)
      Urakami, T., Sakai, K., Asai, T., et al.
    • Journal Title

      Nucl. Med. Biol. 36

      Pages: 295-303

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats.2009

    • Author(s)
      Takahama, H., Minamino, T., Asanuma, H., (1), Asai, T., (12)
    • Journal Title

      J. Am. Coll. Cardiol. 53

      Pages: 709-717

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography.2009

    • Author(s)
      Urakami, T., Kawaguchi, A.T., Akai, S., (3), Asai, T., (4)
    • Journal Title

      Artif. Organs 33

      Pages: 164-168

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of O-[(18)F] fluoromethyl-d-tyrosine as a radiotracer for turn or imaging with positron emission tomography2009

    • Author(s)
      Urakami, T., et.al.
    • Journal Title

      Nucl. Med. Biol 36

      Pages: 295-303

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardionrotection in rats2009

    • Author(s)
      Takahama, H., et.al.
    • Journal Title

      J. Am. Coll. Cardiol 53

      Pages: 709-717

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography2009

    • Author(s)
      Urakami, T., et.al.
    • Journal Title

      Artif. Organs 33

      Pages: 164-168

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Particle size-dependent triggering of accelerated blood clearance phenomenon.2008

    • Author(s)
      Koide, H., Asai, T., Hatanaka, K., et al.
    • Journal Title

      Int. J. Pharm. 362

      Pages: 197-200

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC.2008

    • Author(s)
      Asai, T., Miyazawa, S., Maeda, N., et al.
    • Journal Title

      Cancer Sci. 99

      Pages: 1029-1033

    • NAID

      10024006453

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.2008

    • Author(s)
      Asai, T., Suzuki, Y., Matsushita, S., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 368

      Pages: 243-248

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antineovascular gene therapy by ago2 knockdown2008

    • Author(s)
      Hatanaka, K., et.al.
    • Journal Title

      Yakugaku Zasshi 128

      Pages: 1567-1575

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Particle size-dependent triggering of accelerated blood clearance phenomenon2008

    • Author(s)
      Koide, H., et.al.
    • Journal Title

      Int. J. Pharm 362

      Pages: 197-200

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective delivery of an angiogenesis inhibitor by neovessel-targeted lipo somes2008

    • Author(s)
      Katanasaka, Y., et.al.
    • Journal Title

      Int. J. Pharm 360

      Pages: 219-224

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3, 5-dimethyl-1H-pyrrol-2-ylmethylene)-1, 3-dihydro-indol-2-one, SU54162008

    • Author(s)
      Katanasaka, Y., et.al.
    • Journal Title

      Cancer Lett 270

      Pages: 260-268

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced experimental tumor metastasis with age in senescence-acceler ated mouse2008

    • Author(s)
      Shimizu, K., et.al.
    • Journal Title

      Biol. Pharm. Bull 31

      Pages: 847-851

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded Aliposomal DPP-CNDAC2008

    • Author(s)
      Asai, T., et. al.
    • Journal Title

      Cancer Sci 99

      Pages: 1029-1033

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anew approach for drug discovery from glycobiology and phage-displayed peptide library technology2008

    • Author(s)
      Taki, T., et. al.
    • Journal Title

      Biochim.Biophys.Acta 1780

      Pages: 497-503

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown2008

    • Author(s)
      Asai, T., et. al.
    • Journal Title

      Biochem.Biophys.Res.Commun 368

      Pages: 243-248

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake2008

    • Author(s)
      Imanaka, H., et. al.
    • Journal Title

      Biol. Pharm. Bull 31

      Pages: 400-404

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronopharmacologic cancer treatment with an angiogenic vessel-targeted linosomal drug2008

    • Author(s)
      Shimizu, K., et. al.
    • Journal Title

      Biol.Pharm.Bull 31

      Pages: 95-98

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic characterization of angiogenic endothelial cells stimulated with cancer cell-conditioned medium2007

    • Author(s)
      Katanasaka, Y., et. al.
    • Journal Title

      Biol.Pharm.Bull 30

      Pages: 2300-2307

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍新生血管標的化リボソーム2007

    • Author(s)
      浅井 知浩, ら
    • Journal Title

      Mebio Oncology 4

      Pages: 48-57

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ポリカチオンリポソームを用いた遺伝子デリバリーシステムの開発2007

    • Author(s)
      梅本 拓也, ら
    • Journal Title

      Progr.Drug Delivery Syst 16

      Pages: 45-51

    • Related Report
      2007 Annual Research Report
  • [Presentation] PET technology to determine pharmacokinetics of liposomal siRNA.2009

    • Author(s)
      Asai, T., et al.
    • Organizer
      4th International Liposome Society Conference
    • Place of Presentation
      London, UK
    • Year and Date
      2009-12-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of siRNA delivery system using novel polycation liposomes for cancer therapy.2009

    • Author(s)
      Kenjo, E., et al.
    • Organizer
      4th International Liposome Society Conference
    • Place of Presentation
      London, UK
    • Year and Date
      2009-12-14
    • Related Report
      2009 Final Research Report
  • [Presentation] PET technology to determine pharmacokinetics of liposomal siRNA2009

    • Author(s)
      Tomohiro Asai, et al
    • Organizer
      4th International Liposome Society Conference
    • Place of Presentation
      London, UK
    • Year and Date
      2009-12-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of siRNA delivery system using novel polycation liposomes for cancer therapy2009

    • Author(s)
      Eriya Kenjio, et al.
    • Organizer
      4th International Liposome Society Conference
    • Place of Presentation
      London, Uk
    • Year and Date
      2009-12-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Elucidation of ABC phenomenon caused by repeat injection of PEGylated nanocarrier2009

    • Author(s)
      Hiroyuki Koide, et al.
    • Organizer
      4th International Liposome Society Conference
    • Place of Presentation
      London, Uk
    • Year and Date
      2009-12-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of in vivo delivery system for siRNA-based cancer therapy.2009

    • Author(s)
      Tsuzuku, T., et al.
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-30
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of in vivo delivery system for siRNA-based cancer therapy2009

    • Author(s)
      Takuma Tsuzuku, et al.
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] RNA創薬研究におけるPETイメージング技術の開発2009

    • Author(s)
      畑中剣太郎, ら
    • Organizer
      第9回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Liposomal Polyamine-Dialky1 Phosphate Conjugates as Effective Gene Carriers : Chemical Structure, Morphology, and Gene Transfer Activity2009

    • Author(s)
      Takehisa Dewa, et al.
    • Organizer
      3rd International Symposium on Nanomedicine
    • Place of Presentation
      岡崎
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Polyamine-lipid/DNA Complexes as Gene Carriers : Morphological Observation of the Complexes by Using AFM2009

    • Author(s)
      Kiyoshi Kato, et al.
    • Organizer
      3rd International Symposium on Nanomedicine
    • Place of Presentation
      岡崎
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of PET technology to determine pharmacokinetics of siRNA medicine.2009

    • Author(s)
      Tomohiro Asai
    • Organizer
      APSTJ Global Education Seminar East 2009-03
    • Place of Presentation
      東京
    • Year and Date
      2009-10-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリアミン脂質による遺伝子送達とDNA複合体形態の直接観察2009

    • Author(s)
      出羽毅久, ら
    • Organizer
      第58高分子討論会
    • Place of Presentation
      熊本
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリアミン脂質-DNA複合体のAFMによる形態観察と遺伝子送達能2009

    • Author(s)
      出羽毅久, ら
    • Organizer
      第19回バイオ・高分子シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of PET technology for the pharmacokinetic study of siRNA medicine2009

    • Author(s)
      Kentaro Hatanaka, et al.
    • Organizer
      36th Annual Meeting & Exposition of Controlled Release Society
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2009-07-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] siRNA体内動態のPET解析と新規ベクターの開発2009

    • Author(s)
      浅井知浩, ら
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 新規標的化戦略"複標的化"リポソームを用いた腫瘍新生血管傷害療法2008

    • Author(s)
      村瀬悠希, ら
    • Organizer
      平成20年度日本薬学会東海支部例会
    • Place of Presentation
      静岡
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ポリカチオンリポソーム遺伝子導入法におけるポリアミン構造の導入効率に及ぼす効果2008

    • Author(s)
      庭田佳代子, ら
    • Organizer
      平成20年度日本薬学会東海支部例会
    • Place of Presentation
      静岡
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Angiogenic vessel-targeted liposomal DDS for cancer treatment2008

    • Author(s)
      Asai, T., et.al.
    • Organizer
      11th Liposome Research Days Conference
    • Place of Presentation
      横浜
    • Year and Date
      2008-08-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Antiangiogenic effect by Argonaute2 knockdown used polycation liposome2008

    • Author(s)
      Matsushita, S, et.al.
    • Organizer
      11th Liposome Research Days Conference
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of liposomal siRNA targeting tumor angiogenic vessels2008

    • Author(s)
      Kenjo, E, et.al.
    • Organizer
      11th Liposome Research Days Conference
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Angiogenic vessel-targeted liposomal DDS for cancer treatment.2008

    • Author(s)
      Asai, T., et al.
    • Organizer
      11th Liposome Research Days Conference
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-20
    • Related Report
      2009 Final Research Report
  • [Presentation] Enhancement of the anticancer activity in antineovascular therapy by a novel strategy, "dual-targeting".2008

    • Author(s)
      Murase, Y., et al.
    • Organizer
      11th Liposome Research Days Conference
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-20
    • Related Report
      2009 Final Research Report
  • [Presentation] Enhancement of the anticancer activity in antineovascular therapy by a novel strategy, "dual-targeting"2008

    • Author(s)
      Murase, Y, et.al.
    • Organizer
      11th Liposome Research Days Conference
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Antineovascular therapy by using dual-targeting liposomes2008

    • Author(s)
      Murase, Y, et.al.
    • Organizer
      35th Annual Meeting & Exposition of the Control led Release Society
    • Place of Presentation
      New York
    • Year and Date
      2008-07-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of angiogenic vessel-targeted polycation liposomes for deliv ering small interfering RNA2008

    • Author(s)
      Matsushita, S, et.al.
    • Organizer
      35th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      New York
    • Year and Date
      2008-07-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] ナノキャリア頻回投与時におけるABC現象の機構解明2008

    • Author(s)
      小出裕之, ら
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-30
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Angiogenic vessel-targeted liposomes for in vivo delivery of siRNA.2008

    • Author(s)
      Asai, T., et al.
    • Organizer
      Japan Society of Gene Therapy. The 14th Annual Meeting
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Angiogenic vessel-targeted liposomes for in vivo delivery of siRNA2008

    • Author(s)
      Asai, T., et.al.
    • Organizer
      Japan Society of Gene Therapy. The 14th Annual Meeting 2008
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] ポリカチオンリポソームを用いた遺伝子導入におけるポリアミン構造が導入効率に及ぼす効果2008

    • Author(s)
      庭田佳代子, ら
    • Organizer
      日本薬剤学会第23回年会
    • Place of Presentation
      札幌
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] mTORノックダウンによるがん治療法の開発2007

    • Author(s)
      横田洵一, ら
    • Organizer
      平成19年度日本薬学会東海支部例会
    • Place of Presentation
      岐阜
    • Year and Date
      2007-12-08
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] T cell-independent B cell response induces accelerated blood clearance phenomenon caused by a repeated injection o PEGylated liposomes2007

    • Author(s)
      Hiroyuki Koide, et. al.
    • Organizer
      International Liposome Society 2007 Annual Meeting
    • Place of Presentation
      London,UK
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of Novel Engineering Technology for Preparing Liposomal siRNA2007

    • Author(s)
      Atsushi Tsuruta, et. al.
    • Organizer
      International Liposome Society 2007 Annual Meeting
    • Place of Presentation
      London,UK
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 核酸医薬創成に向けた新規siRNA搭載技術の開発2007

    • Author(s)
      鶴田敦, ら
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 核酸医薬創成に向けた新規siRNA搭載技術の開発2007

    • Author(s)
      鶴田 敦, ら
    • Organizer
      第29回 生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規ポリカチオンリポソームを用いた遺伝子デリバリーシステムの開発2007

    • Author(s)
      梅本 拓也, ら
    • Organizer
      第16回DDSカンファランス
    • Place of Presentation
      静岡
    • Year and Date
      2007-07-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 標的化リポソームを用いた胃がん由来腹膜播種性転移がんに対する治療2007

    • Author(s)
      清水 広介, ら
    • Organizer
      第23回日本DDS学会
    • Place of Presentation
      熊本
    • Year and Date
      2007-06-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of Antineovascular RNAi Cancer Therapy Targeting to Argonaute22007

    • Author(s)
      Tomohiro Asai, et. al.
    • Organizer
      American Society of Gene Therapy 10th Annual Meeting
    • Place of Presentation
      Seattle,WA,USA
    • Year and Date
      2007-05-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腫瘍新生血管を標的としたsiRNAデリバリーの構築とArgonaute2-siRNAによる抗血管新生効果2007

    • Author(s)
      松下 小緒里, ら
    • Organizer
      第7回遺伝子・デリバリー研究会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-05-18
    • Related Report
      2007 Annual Research Report
  • [Book] Angiogenic Vessel-Targeting DDS by Liposomalized Oligopeptides. Methods in Molecular Biology, chapter 232010

    • Author(s)
      Asai, T., Oku, N.
    • Publisher
      Humana Press
    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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