Preparation of lipid nanoparticles modified with cell penetrating peptide for antitumor drug delivery

Research Project

Project/Area Number	19790140
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Medical pharmacy
Research Institution	Hoshi University
Principal Investigator	KAWANO Kumi Hoshi University, 薬学部, 助教 (20366834)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,260,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥660,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords	抗がん剤 / 脂質微粒子 / リポソーム / 正電荷 / 腫瘍新生血管 / ドラッグデリバリー / 抗癌剤 / 癌化学療法 / 膜透過性ペプチド
Research Abstract	To improve the chemotherapeutic agents accumulation in tumor tissue, lipid nanoparticles was modified with oligoarginine lipid or cationic lipid. These particles showing cationic charge were accumulated in tumor tissue and tumor vasculature, and enhanced the antitumor activities.

Report

(3 results)