Development of metastatic breast cancer therapies with anticancer drug-loaded inorganic nanoparticles targeted to lymph nodes
| Project/Area Number |
19790143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Fujita Health University |
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Principal Investigator |
MURAKAMI Tatsuya Fujita Health University, 物質-細胞統合システム拠点, 特定拠点助教 (90410737)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | ドラッグデリバリー / ナノ粒子 / カーボンナノチューブ / 癌化学療法 / 乳癌 / リンパ節転移 / 腋窩リンパ節 / ドラッグキャリア |
|---|
| Research Abstract |
Novel drug-drug carrier complexes with a new type of nanocarbon material, carbon nanohorn (CNH), have been developed. CNH was easily loaded with an anticancer drug, doxorubicin (DXR). The complex slowly released DXR, which would contribute to enhancement of the antitumor activity. When CNH was loaded with an photosensitizer, zinc phthalocyanine (ZnPc), the complex enabled double photodynamic and photothermal cancer therapies. More importantly, CNH administered into tumor-bearing mice was able to accumulate in the adjacent axial lymph nodes, which are well known to be an organ in which breast cancer metastasis often occurs.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd2O3 labels.2009
Author(s)
J. Miyawaki, S. Matsumura, R. Yuge, T. Murakami, S. Sato, A. Tomida, T. Tsuruo, T. Ichihashi, T. Fujinami, H. Irie, K. Tsuchida, S. Iijima, K. Shiba, M. Yudasaka
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Journal Title
ACS Nano 3
Pages: 1399-1406
Related Report
Peer Reviewed
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[Journal Article] Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd203 labels2009
Author(s)
Miyawaki, J., Matsumura, S., Yuge, R., Murakami, T., Sato, S., Tomida, A., Tsuruo, T., Ichihashi, T., Fujinami, T., Irie, R., Tsuchida, K., Iijima, S., Shiba, K., Yudasaka, M.
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Journal Title
ACS Nano 3
Pages: 1399-1406
Related Report
Peer Reviewed
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[Journal Article] Photoinduced electron transfer in zinc phthalocyanine loaded on single-walled carbon nanohorns in aqueous solution2009
Author(s)
Sandanayaka, A.S.D., Ito, O., Zhang, M., Ajima, K., Iijima, S., Yudasaka, M., Murakami, T., Tsuchida, K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article]2008
Author(s)
T. Murakami, H. Sawada, G. Tamura, M. Yudasaka, S. Iijima, K. Tsuchida
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Journal Title
Related Report
Peer Reviewed
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