The analysis of cell-cell barrier function in intestine
| Project/Area Number |
19790150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka University |
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Principal Investigator |
TAMURA Atsushi Osaka University, 生命機能研究科, 特任助教 (00362525)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | タイトジャンクション / クローディン / ノックアウトマウス / 腸管 / ホメオスタシス / 上皮細胞 / バリア / ノックアウト / 小腸肥大 |
|---|
| Research Abstract |
Epithelial cell sheets have an important role in compartmentalizing internal tissues and maintaining their local homeostasis via intercellular barriers consisting of tight junctions. Using claudin-15 knockout mice, we proposed that claudin-15-based formation of tight junctions to organize was important for the ion like Na+ microenvironment in the small intestine. As the absorption of many kinds of nutrients like glucose is coupled directly to Na+ absorption, this result is essential for our life.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Megaintestine in claudin-15- deficient mice.2008
Author(s)
Tamura, A., Kitano, Y., Hata, M., Katsuno, T., Moriwaki, K., Sasaki, H., Hayashi, H, Suzuki, Y., Noda, T., Furuse, M., Tsukita, Sh., Tsukita. Sa.
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Journal Title
Gastroenterology 134
Pages: 523-534
Related Report
Peer Reviewed
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[Journal Article] Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.2008
Author(s)
Katsuno, T., Umeda, K., Matsui, T., Hata, M., Tamura, A., Itoh, M., Takeuchi, K., Fujimori, T., Nabeshima, Y., Noda, T., Tsukita, Sh., Tsukita. Sa.
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Journal Title
Mol. Biol. Cell 19
Pages: 2465-2475
Related Report
Peer Reviewed
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