| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Research Abstract |
Epithelial cell sheets have an important role in compartmentalizing internal tissues and maintaining their local homeostasis via intercellular barriers consisting of tight junctions. Using claudin-15 knockout mice, we proposed that claudin-15-based formation of tight junctions to organize was important for the ion like Na+ microenvironment in the small intestine. As the absorption of many kinds of nutrients like glucose is coupled directly to Na+ absorption, this result is essential for our life.
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