Role for autophagy in axons and pre-synaptic terminals.

• Project/Area Number: 19790151
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Juntendo University (2008); Osaka University (2007)
• Principal Investigator: KOIKE Masato Juntendo University, 医学部, 先任准教授 (80347210)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: リソソーム / オートファジー / カテプシン / ダブルノックアウトマウス / 軸索 / spheroid

Research Abstract

リソソームタンパク分解酵素カテプシンを複数欠損させた3系統のマウスの神経組織を解析した結果、神経細胞の軸索においては、処理されなかったオートファゴソームが蓄積するという現象が一般的に認められることが明らかとなった。これは正常神経細胞の軸索においては軸索内において形成されたオートファゴソームが細胞体に輸送された後リソソームにより速やかに分解を受けるという機構が存在することが推察された。

Research Products

• [Journal Article] The MAP1-LC3 conjugation system is involved in lipid droplet formation. (2009)
  • Author(s): Shibata M. *, Yoshimura, K. *, Furuya, N., Koike M., Ueno, T., Komatsu, M., Arai, H., Tanaka, K., Kominami, E., Uchiyama, Y.
  • Journal Title: Biochem. Biophys. Res. Commun. 382(2) Pages: 419-423
  • Peer Reviewed
• [Journal Article] The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. (2009)
  • Author(s): Nada, S., * Hondo, A., * Kasai, A., * Koike, M. *, Saito, K., Uchiyama, Y., Okada, M.
  • Journal Title: EMBO J. 28(5) Pages: 477-489
  • Peer Reviewed
• [Journal Article] Participation of Autophagy in the Initiation of Graft Dysfunction after Rat Liver Transplantation. (2009)
  • Author(s): Gotoh, K., Lu, Z., Morita, M., Shibata, M., Koike, M., Waguri, S., Dono, K., Kominami, E., Sugioka, A., Monden, M., Uchiyama, Y.
  • Journal Title: Autophagy 5(3) Pages: 351-360
  • Peer Reviewed
• [Journal Article] Very High Dose α-tocopherol Supplementation Increases Blood Pressure and Causes Possible Adverse CNS Effects in Stroke-Prone Spontaneously Hypertensive Rats. (2009)
  • Author(s): Miyamoto, K., Shiozaki, M., Shibata, M., Koike, M., Uchimaya, Y., Gotow, T.
  • Journal Title: J. Neurosci. Res. 87(2) Pages: 556-566
  • Peer Reviewed
• [Journal Article] GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (2008)
  • Author(s): Maeda, Y., Ide T., Koike, M., Uchiyama, Y., Kinoshita, T.
  • Journal Title: Nat. Cell Biol. 10(10) Pages: 1135-1145
  • Peer Reviewed
• [Journal Article] Inefficient phagosome maturation in infant macrophages. (2008)
  • Author(s): Saito, F., Kuwata, H., Oiki, E., Koike, M., Uchiyama, Y., Honda, K., Takeda, K.
  • Journal Title: Biochem. Biophys. Res. Commun. 375(1) Pages: 113-118
  • Peer Reviewed
• [Journal Article] Human Herpesvirus-6 Induces MVB Formation and Virus Egress Occurs by an Exosomal Release Pathway. (2008)
  • Author(s): Mori, Y.*, Koike, M.*, Moriishi, E., Kawabata, A., Tang, H., Oyaizu, H., Uchiyama, Y., Yamanishi, K.
  • Journal Title: Traffic 9(10) Pages: 1728-1742
  • Peer Reviewed
• [Journal Article] オートファジーと神経細胞死 (2008)
  • Author(s): 小池正人、内山安男
  • Journal Title: 医学のあゆみ 225(6) Pages: 491-494
• [Journal Article] Morphological and Biochemical Signs of Age-related Neurodegenerative Changes in Klotho Mutant Mice. (2008)
  • Author(s): Shiozaki, M., Yoshimura, K., Shibata, M., Koike, M., Uchiyama, Y., Gotow, T.
  • Journal Title: Neuroscience 152(4) Pages: 924-941
  • Peer Reviewed
• [Journal Article] Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility. (2008)
  • Author(s): Takatsuka, A., Yagi, R., Koike, M., Oneyama, C., Nada, S., Schmedt, C., Uchiyama, Y., Okada, M.
  • Journal Title: Dev. Biol. 315(2) Pages: 474-488
  • Peer Reviewed
• [Journal Article] Participation of autophagy in renal ischemia/reperfusion injury. Biochem. (2008)
  • Author(s): Suzuki, C., Isaka, Y., Takabatake, Y., Tanaka, H., Koike, M., Shibata, M., Uchiyama, Y., Takahara S., Imai, E.
  • Journal Title: Biophys. Res. Commun. 368(1) Pages: 100-106
  • Peer Reviewed
• [Journal Article] Developing Post-Mitotic Mammalian Neurons In Vivo Lacking Apaf-1 Undergo Programmed Cell Death by a Caspase-Independent, Non-Apoptotic Pathway Involving Autophagy. (2008)
  • Author(s): Oppenheim, RW., Blomgren, K., Ethell, DW., Koike, M., Komatsu, M., Prevette, D., Roth, KA., Uchiyama, Y., Vinsant, S., Zhu, C.
  • Journal Title: J. Neurosci. 28(6) Pages: 1490-1497
• [Journal Article] Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury. (2008)
  • Author(s): Koike, M., Shibata, M., Tadakoshi, M., Gotoh, K., Komatsu, M., Waguri, S., Kawahara, N., Kuida, K., Nagata, S., Kominami, E., Tanaka, K., Uchiyama, Y.
  • Journal Title: Am. J. Pathol. 172(2) Pages: 454-469
  • Peer Reviewed
• [Journal Article] Autophagy-Physiology and Pathophysiology (2008)
  • Author(s): Uchiyama Y, et.al.
  • Journal Title: Histochem Cell Biol 129 Pages: 407-420
  • Peer Reviewed
• [Journal Article] Autophagic neuron death in neonatal brain ischemia/hypoxia (2008)
  • Author(s): Uchiyama Y, et.al.
  • Journal Title: Autophagy 4 Pages: 404-408
  • Peer Reviewed
• [Journal Article] Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility (2008)
  • Author(s): Takatsuka A, et.al.
  • Journal Title: Dev Biol 315 Pages: 474-488
  • Peer Reviewed
• [Journal Article] Morphological and biochemical signs of age-related neurodegene rative changes in Klotho mutant mice (2008)
  • Author(s): Shiozaki M, et.al.
  • Journal Title: Neuroscience 152 Pages: 924-941
  • Peer Reviewed
• [Journal Article] Inefficient phagosome maturation in infant macrophages (2008)
  • Author(s): Saito F, et.al.
  • Journal Title: Biochem Biophys Res Commun 375 Pages: 113-118
  • Peer Reviewed
• [Journal Article] Human herpesvirus-6 induces MVB formation and virus egress occurs via an exosomal release pathway (2008)
  • Author(s): Mori Y*, Koike M*, et.al.(*equal contributors)
  • Journal Title: Traffic 9 Pages: 1728-1742
  • Peer Reviewed
• [Journal Article] GPHR is a novel anion channel critical for acidification and 'functions of the. Golgi apparatus (2008)
  • Author(s): Maeda Y, et.al.
  • Journal Title: Nat Cell Biol 10 Pages: 1135-1145
  • Peer Reviewed
• [Journal Article] Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury. (2008)
  • Author(s): Koike, et. al.
  • Journal Title: Am. J. Pathol 172 Pages: 454-469
  • Peer Reviewed
• [Journal Article] Developing Post-Mitotic Mammalian Neurons In Vivo Lacking Apaf-1 Undergo Programmed Cell Death by a Caspase-Independent, Non-Apoptotic Pathway Involving Autophagy. (2008)
  • Author(s): Oppenheim, et. al.
  • Journal Title: J. Neurosci. 28 Pages: 1490-1497
  • Peer Reviewed
• [Journal Article] Participation of autophagy in renal ischemia/reperfusion injury. (2008)
  • Author(s): Suzuki, et. al.
  • Journal Title: Biochem. Biophys. Res. Commun. 368 Pages: 300-306
  • Peer Reviewed
• [Journal Article] Generation of a Recombinant Oka Varicella Vaccine Expressing Mumps Virus Hemagglutinin-Neuraminidase Protein as a Polyvalent Live Vaccine. (2007)
  • Author(s): Somboonthum, P., Yoshii, H., Okamoto, S., Koike, M., Gomi, Y., Uchiyama, Y., Takahashi, N., Yamanishi, K., Mori, Y.
  • Journal Title: Vaccine 25(52) Pages: 8741-8755
  • Peer Reviewed
• [Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. (2007)
  • Author(s): Komatsu, M., Waguri, S., Koike, M., Sou, Y., Ueno, T., Hara, T., Mizushima, N., Iwata, J., Ezaki, J., Murata, S., Hamasaki, J., Nishito, Y., Iemura, S., Natsume, T., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K.
  • Journal Title: Cell 131(6) Pages: 1149-1163
  • Peer Reviewed
• [Journal Article] Identification of Tim-4 as a phosphatidylserine receptor. (2007)
  • Author(s): Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., Nagata, S.
  • Journal Title: Nature 450(7168) Pages: 435-439
  • Peer Reviewed
• [Journal Article] RGS18 acts as a negative regulator of osteoclastogenesis by modulating acid-sensing OGR1/NFAT signaling pathway. (2007)
  • Author(s): Iwai K., Koike, M., Ohshima S., Miyatake, K., Uchiyama, Y., Saeki, Y., Ishii, M.
  • Journal Title: J Bone Miner Res. 22(10) Pages: 1612-1620
  • Peer Reviewed
• [Journal Article] Lysosomal Degradation of Nuclear DNA by DNase II-like Acid DNase in Cortical Fiber Cells of Mouse Eye Lens. (2007)
  • Author(s): Nakahara, M., Nagasaka, A., Koike, M., Uchida, K., Kawane, K., Uchiyama, Y., Nagata, S.
  • Journal Title: FEBS J. 274(12) Pages: 3055-3064
  • Peer Reviewed
• [Journal Article] Lysosomal Degradation of Nuclear DNA by DNase II-like Acid DNase in Cortical Fiber Cells of Mouse Eve Lens. (2007)
  • Author(s): Nakahara, et. al.
  • Journal Title: FEBS J 274 Pages: 3055-3064
  • Peer Reviewed
• [Journal Article] RGS18 acts as a negative regulator of osteoclastogenesis by modulating acid-sensing OGR1/NFAT signaling pathway. (2007)
  • Author(s): Iwai, et. al.
  • Journal Title: J Bone Miner Res. 22 Pages: 1612-20
  • Peer Reviewed
• [Journal Article] Identification of Tim-4 as a phosphiatidylserine receptor. (2007)
  • Author(s): Miyanishi, et. al.
  • Journal Title: Nature 450 Pages: 435-439
  • Peer Reviewed
• [Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. (2007)
  • Author(s): Komatsu, et. al.
  • Journal Title: Cell 131 Pages: 1149-1163
  • Peer Reviewed
• [Journal Article] Generation of a Recombinant Oka Varicella Vaccine Expressing Mumps Virus Hemagglutinin-Neuraminidase Protein as a Polyyalent Live Vaccine. (2007)
  • Author(s): Somboonthum, et. al.
  • Journal Title: Vaccine 25 Pages: 8741-8755
  • Peer Reviewed
• [Presentation] リソゾーム蓄積症の病態形成にオートファジーが果たす役割について (2009)
  • Author(s): 小池正人、内山安男
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] GPHRはゴルジ装置の酸性化・機能にとって重要な新規アニオンチャネルである (2009)
  • Author(s): 前田裕輔ら
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] マウスDNaseIIのプロセッシングに関する研究 (2009)
  • Author(s): 大河内進ら
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] 膜局在型オートファジー関連遺伝子産物Atg9Aの組織及び細胞内分布について (2009)
  • Author(s): 多村博澄ら
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] ヒトヘルペスウイルス6粒子はエクソソーム経路を経て細胞外に放出される (2009)
  • Author(s): 小池正人ら
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] レスベラトロールはSAMP10の神経細胞及び肝細胞の老化関連変化を改善する (2009)
  • Author(s): 塩崎元子ら
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] レスベラトロールの未分化及び分化PC12細胞における影響 (2009)
  • Author(s): 竹内翔一ら
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] エタノール障害中枢神経細胞と肝細胞におけるキサントシンの緩和作用 (2009)
  • Author(s): 早川直哉ら
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山理科大学
• [Presentation] Acidification of the the Golgi apparatus is regualated by GPHR, a novel anion channel, and critical for glycosylation (2008)
  • Author(s): Maeda, et.al.
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2008-12-10
• [Presentation] The role of macroautophagy in the pathogenesis of lysosomal storage disease due to cathepsin D deficiency (2008)
  • Author(s): Koike, et.al.
  • Organizer: Neuroscience 2008, 38th Annual Meeting Society for Neuroscience
  • Place of Presentation: Washington Convention Center
  • Year and Date: 2008-11-17
• [Presentation] Lysosomal cathepsin D in neurons is in part delivered from glial cells (2008)
  • Author(s): Shibata, et.al.
  • Organizer: Neuroscience 2008, 38th Annual Meeting Society for Neuroscience
  • Place of Presentation: Washington Convention Center
  • Year and Date: 2008-11-17
• [Presentation] Human herpesvirus-6 induces MVB formation and virus egress via an exosomal release pathway (2008)
  • Author(s): Mori and Koike, et.al.
  • Organizer: 第60会日本細胞生物学会大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-07-01
• [Presentation] Acidification of the Golgi apparatus is regurated by GPHR, a novel anion channel, and critical for glycosylation. (2008)
  • Author(s): Yusuke Maeda ら
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートピアホテル
• [Presentation] エンドソームアダプターp18とリン酸化シグナリング (2008)
  • Author(s): 名田茂之ら
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートピアホテル
• [Presentation] The role of macroautophagy in the pathogenesis of lysosomal storage disease due to cathepsin D deficiency. (2008)
  • Author(s): Masato Koike ら
  • Organizer: 38th Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン
• [Presentation] Lysosomal cathepsin D in neurons is in part delivered from glial cells. (2008)
  • Author(s): Masahiro Shibata ら
  • Organizer: 38th Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン
• [Presentation] エタノール細胞障害における赤ワインと白ワインエキスの修復能の効果 (2008)
  • Author(s): 塩崎元子ら
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] マウス脳におけるカテプシンDの再取り込み (2008)
  • Author(s): 柴田昌宏ら
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 低酸素-脳虚血負荷後の海馬錐体細胞の細胞死におけるオートファジーの関与について (2008)
  • Author(s): 小池正人ら
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] Human herpesvirus-6 induces MVB formation and virus egress via an exosomal release pathway. (2008)
  • Author(s): Yasuko Mori ら
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 低酸素-脳虚血負荷に伴う海馬錐体細胞の細胞死はオートファジー性細胞死である (2008)
  • Author(s): 小池正人ら
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分大学医学部
• [Presentation] 神経系特異的カテプシンD欠損マウスについて (2008)
  • Author(s): 柴田昌宏ら
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分大学医学部
• [Presentation] エタノール傷害性ラット肝臓及び中枢神経系における赤ワイン及び白ワインエキスの緩和効果 (2008)
  • Author(s): 塩崎元子ら
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分大学医学部
• [Presentation] マウスAtg9A抗体の作製と組織細胞内分布について (2008)
  • Author(s): 多村博澄ら
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分大学医学部
• [Presentation] 高齢ラット中枢神経系の神経細胞における植物化学物質、キサントシンの効果 (2008)
  • Author(s): 早川直哉ら
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分大学医学部
• [Presentation] 高齢ラット肝細胞における植物化学物質、キサントシンの効果 (2008)
  • Author(s): 竹内翔一ら
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分大学医学部
• [Presentation] 抗マウスDNaseII 抗体の作製と同タンパク質の免疫組織化学的局在について (2008)
  • Author(s): 大河内進ら
  • Organizer: 第113回日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分大学医学部
• [Presentation] Selective autophagy regulates formation of cytoplasimc inclusions. (2007)
  • Author(s): Komatsu, et. al.
  • Organizer: 第30回日本分子生物学会年会第80回日本生化学会大会合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-13
• [Presentation] Involvement of autophagy in neurons of the hippocampus after adult mouse hypoxic-ischemic injury. (2007)
  • Author(s): Koike, et. al.
  • Organizer: 76th Annual Meeting Society for Neuroscience
  • Place of Presentation: サンディェゴ
  • Year and Date: 2007-11-06
• [Presentation] カテプシンD欠損に伴うリソソーム畜積症の病態形成について (2007)
  • Author(s): 小池正人, ら
  • Organizer: 第50回日本神経化学会大会、第17回日本神経回路学会大会合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-11
• [Presentation] 中枢神経特異的カテプシンD欠損による神経性セロイドリポフスチン蓄積症類似症状の誘導 (2007)
  • Author(s): 柴田昌宏, ら
  • Organizer: 第50回日本神経化学会大会、第17回日本神経回路学会大会合同大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-11
• [Presentation] Selective autophagy regulates formation of cytoplasmic ninclusions. (2007)
  • Author(s): Masaaki Komatsu ら
  • Organizer: 第30回日本分子生物学会年会第80回日本生化学会大会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] The roles of lysosomal proteinases in primary hepatocyte death induced by TNF-α and actinomycin D. (2007)
  • Author(s): Noriyuki Yamamura ら
  • Organizer: 58th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: シカゴ
• [Presentation] Involvement of autophagy in neurons of the hippocampus after adult mouse hypoxic-ischemic injury. (2007)
  • Author(s): Masato Koike ら
  • Organizer: 37th Annual Meeting Society for Neuroscience
  • Place of Presentation: サンディエゴ
• [Presentation] Augumented Autophagy Protects against Ischemia/Reperfusion Injury in Tubular Epithelial Cells. (2007)
  • Author(s): Chigure Suzuki ら
  • Organizer: American Society of Nephrology's Renal Week 2007
  • Place of Presentation: サンフランシスコ
• [Presentation] カテプシンD欠損に伴うリソソーム蓄積症の病態形成について (2007)
  • Author(s): 小池正人ら
  • Organizer: 第30回日本神経科学大会、第50回日本神経化学会大会、第17回日本神経回路学会大会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 中枢神経特異的カテプシンD欠損による神経性セロイドリポフスチン蓄積症類似症状の誘導 (2007)
  • Author(s): 柴田昌宏ら
  • Organizer: 第30回日本神経科学大会、第50回日本神経化学会大会、第17回日本神経回路学会大会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Posssible roles of LC3, ubiquitin, and P62 in the accumulation of lysosomes in neurons deficient in Cathepsin D. (2007)
  • Author(s): Masato Koike ら
  • Organizer: 7th IBRO World Congress of Neuroscience
  • Place of Presentation: メルボルン
• [Presentation] A mouse with low expression of Cathepsin D is a model animal of neuronal Ceroid Lipofuscinosis. (2007)
  • Author(s): Shibata Masahiro ら
  • Organizer: 7th IBRO World Congress of Neuroscience
  • Place of Presentation: メルボルン
• [Presentation] 新規ラフト局在蛋白質p18の機能解析-レセプターのリサイクリング制御への関連性 (2007)
  • Author(s): 笠井篤子ら
  • Organizer: 第40回日本発生生物学会・第59回日本細胞生物学会大会合同大会
  • Place of Presentation: 福岡国際会議場
• [Book] Part C Ed. Daniel J. Klionsky (2009)
  • Author(s): Uchiyama, Y., Koike M., Shibata, M., Sasaki, M. Elsevier Inc.
  • Publisher: Monitoring of autophagy in neurodegeneration. Methods Enzymol. In : Autophagy in Disease and Clinical Applications
• [Book] Chapter 3 Autophagic neuron death.Method in Enzymology In : Autophagy in Disease and Clinical Applications, Part C Ed. Daniel J. Klionsky (2009)
  • Author(s): Uchiyama Y, et.al.
  • Publisher: Elsevier Inc
• [Book] Ed. Yuji Kuge.
  • Author(s): Uchiyama, Y., Koike M., Shibata, M.
  • Publisher: Springer Japan. Autophagy and cell death. In : Molecular imaging for integrated medical therapy and drug development.(In press)
• [Remarks]
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/shinkei_kozo/index.html