Developmental and evolutional mechanisms of the primary sensory neurons

• Project/Area Number: 19790156
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Jichi Medical University
• Principal Investigator: YAJIMA Hiroshi Jichi Medical University, 医学部, 講師 (10433583)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 脊髄神経節 / 知覚神経 / 神経堤細胞 / Six遺伝子 / 発生・分化 / 感覚神経

Research Abstract

脊椎動物体幹部の感覚を司る脊髄神経節の発生プログラムにおいて、複数の局面でSix遺伝子が重要な役割を担っていることを明らかにした。特に、感覚神経細胞の発生過程において、Six遺伝子を発現できるようになったことが感覚神経の進化・多様化の鍵になっている可能性を示すことが出来た。また、感覚神経細胞の分化機構と脊髄神経節の節という形態の形成・維持機構が互いに密接に関与しあい不可分である可能性も示すことが出来た。

Research Products

• [Journal Article] Multiple evolutionarily conserved enhancers control expression of Eya1 (2008)
  • Author(s): Ishihara T., Sato S., Ikeda K., Yajima H. and Kawakami K.
  • Journal Title: Developmental Dynamics 237(11) Pages: 3142-3156
  • Peer Reviewed
• [Journal Article] Differential expression of Eya1 and Eya2 during chick early embryonic development (2008)
  • Author(s): Ishihara T., Ikeda K., Sato S., Yajima H. and Kawakami K.
  • Journal Title: Gene Expression Patterns 8(5) Pages: 357-367
  • Peer Reviewed
• [Journal Article] Steady-state increase of CREB, Rac and PAK signaling in Presenilin-deficient Neurons. (2008)
  • Author(s): Barnes N., Shi J., Yajima H., Thinakaran G. and Parent A.
  • Journal Title: Journal of Neurochemistry 104(6) Pages: 1637-1648
  • Peer Reviewed
• [Journal Article] Multiple evolutionarily conserved enhancers control expressi on of Eyal (2008)
  • Author(s): Tadashi Ishihara
  • Journal Title: Developmental Dynamics 237 Pages: 3142-3156
  • Peer Reviewed
• [Journal Article] Steady-state increase of CREB, Rac and PAK signaling in Presenilin-deficient Neurons. (2008)
  • Author(s): Natalie Y. Barnes
  • Journal Title: Journal of Neurochemistry 104 Pages: 1637-1648
  • Peer Reviewed
• [Journal Article] Differential expression of Eya1 and Eya2 during chick early embryonic development. (2008)
  • Author(s): Tadashi Ishihara
  • Journal Title: Gene Expression Patterns 8 Pages: 357-367
  • Peer Reviewed
• [Journal Article] Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. (2007)
  • Author(s): Peng C., Yajima H., Burns C., Zon L., Sisodia S., Pfaff S. and Sharma K.
  • Journal Title: Neuron 53(6) Pages: 813-827
  • Peer Reviewed
• [Journal Article] Notch and MAML signaling drives Scl-dependent intemeuron diversity in the spinal cord. (2007)
  • Author(s): Chian-Yu Peng
  • Journal Title: Neuron 53 Pages: 813-827
  • Peer Reviewed
• [Presentation] Hidden developmental program of Rohon-Beard cells in mice (2008)
  • Author(s): Hiroshi Yajima, Keiko Ikeda, Shigeru Sato and Kiyoshi Kawakami
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島県郷土文化会館
  • Year and Date: 2008-05-28
• [Presentation] Role of Six1 and Six4 in cranial gangliogenesis (2008)
  • Author(s): Keiko Ikeda, Hiroshi Yajima, Makoto Yamakado, Kiyoshi Kawakami
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島県郷土文化会館
  • Year and Date: 2008-05-28
• [Presentation] Expression patterns of Eya1 and Eya2 in chick early development (2008)
  • Author(s): Tadashi Ishihara, Keiko Ikeda, Shigeru Sato, Hiroshi Yajima, Kiyoshi Kawakami
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島県郷土文化会館
  • Year and Date: 2008-05-28
• [Presentation] Roles of Six genes in the proliferation and differentiation of muscle satellite cells (2007)
  • Author(s): Hiroshi Yajima, Shigeru Sato, Keiko Ikeda, Kaori Miyamoto, Satoru Masuda, Norio Motohashi, Erika Yada, Yuko Suzuki, Shin'ichi Takeda, Kiyoshi Kawakami
  • Organizer: 第40回日本発生生物学会・日本細胞生物学会合同大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-05-30
• [Presentation] Roles of Six genes in the proliferation and differentiation of muscle satellite cells. (2007)
  • Author(s): Hiroshi Yajima
  • Organizer: 第40回日本発生生物学会・日本細胞生物学会合同大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-05-30
• [Remarks]
  • URL: http://www.jichi.ac.jp/biol/home.html
• [Remarks]
  • URL: http://www.jichi.ac.jp/biol/home.html