The role of Dlg in neural crest development.

• Project/Area Number: 19790158
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Fujita Health University
• Principal Investigator: KOGO Akiko Fujita Health University, 医学部, 助教 (20340242)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 発生学 / 形態形成学 / 神経堤 / Dlg / 発生・分化 / 心臓 / 心臓流出路 / ノックアウトマウス / 胸骨 / 骨形成

Research Abstract

Dlg is thought to be a scaffolding protein, which links proteins attached to plasma membrane. Cardiac neural crest cells are known to be involved in the morphogenesis of the heart and outflow tracts. Dlg gene-targeted mice exhibit severe developmental defects in outflow tracts and ventricular septum. We evaluated the possibility that Dlg is involoved in the neural crest development.

Research Products

• [Journal Article] High Expression of Pitx-2 in the ICAT-deficient Metanephros Leads to Developmental Arrest. (2010)
  • Author(s): Hasegawa Y, Iizuka-Kogo A, Akiyama T, Senda T
  • Journal Title: Acta Histochem Cytochem 43(2) Pages: 51-9
  • Peer Reviewed
• [Journal Article] Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis. (2007)
  • Author(s): Yoshimi Hasegawa, Kiyotoshi Satoh, Akiko Iizuka-Kogo, Atsushi Shimomura, Ryuji Nomura, Tetsu Akiyama, Takao Senda
  • Journal Title: Biochemical and Biophysical Research Communications 362 Pages: 988-994
  • Peer Reviewed
• [Journal Article] Requirement of the tumour suppressor APC for the clustering of PSD-95 and AMPA receptors in hippocampal neurons. (2007)
  • Author(s): Atsushi Shimomura, Mahito Ohkuma, Akiko Iizuka-Kogo, Kazuyoshi Kohu, Ryuji Nomura, Ei-ichi Miyachi, Tetsu Akiyama, Takao Senda
  • Journal Title: European Journal of Neuroscience 26(4) Pages: 903-912
  • Peer Reviewed
• [Journal Article] Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis. (2007)
  • Author(s): Yoshimi Hasegawa
  • Journal Title: Biochemical and Biophysical Research Communications 362 Pages: 988-994
  • Peer Reviewed
• [Journal Article] Requirement of the tumour suppressor APC for the clustering of PSD-95 and AMPA receptors in hippocampal neurons. (2007)
  • Author(s): Atsushi Shimomura
  • Journal Title: European Journal of Neuroscience 26(4) Pages: 903-912
  • Peer Reviewed
• [Journal Article] High Expression of Pitx-2 in the ICAT-deficient Metanephros Leads to Developmental Arrest
  • Author(s): Yoshimi Hasegawa
  • Journal Title: Acta Histochemica et Cytochemica (in press)
  • Peer Reviewed
• [Presentation] P0-Cre/CAG-EGFPトランスジェニックマウスを用いた心臓神経堤細胞の可視化とDlg1発現の解析 (2010)
  • Author(s): 千田隆夫、向後晶子
  • Organizer: 日本解剖学会第115回全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-03-29
• [Presentation] 泌尿生殖管の形態形成におけるDlgh1の機能の解析 (2009)
  • Author(s): 向後晶子、千田隆夫
  • Organizer: 日本解剖学会第114回全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-03-30
• [Presentation] 泌尿生殖管の形態形成におけるDlgh1の機能の解析 (2009)
  • Author(s): 向後晶子
  • Organizer: 第114回日本解剖学会全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-03-30
• [Presentation] 光泰C末端欠損APC発現マウス甲状腺の組織形態学的解析 (2009)
  • Author(s): 横山敦司、吉野寧維、尾之内高慶、向後晶子、野村隆士、織田直久、千田隆夫、伊藤
  • Organizer: 第52回日本甲状腺学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] P0-Cre/CAG-GFPトランスジェニックマウスを用いた心臓神経堤細胞の観察 (2009)
  • Author(s): 向後晶子、千田隆夫
  • Organizer: 日本解剖学会第69回中部支部学術講演会
  • Place of Presentation: 浜松
• [Presentation] APC蛋白質のC末端特異的な新規機能の探索 (2009)
  • Author(s): 千田隆夫、下村敦司、尾之内高慶、野村隆士、向後晶子、酒井一由
  • Organizer: 日本解剖学会第69回中部支部学術講演会
  • Place of Presentation: 浜松
• [Presentation] C末端欠損APC発現マウス甲状腺の組織形態学的解析 (2009)
  • Author(s): 横山敦司
  • Organizer: 第52回日本甲状腺学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Morphogenesis of the Mullerian Duct and Requirement of Dlgh1 (2008)
  • Author(s): Akiko Iizuka-Kogo
  • Organizer: International Symposium for Gonad and Brain sex Differentiation
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-09-15
• [Presentation] Morphogenesis of the Mallerian Duct and Requirement of Dlgh1 (2008)
  • Author(s): 向後晶子
  • Organizer: International Symposium for Gonad and Brain sex Differentiation
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-09-15
• [Presentation] The role of Dlgh1 (Discs Large Homolog-1) in organogenesis (2008)
  • Author(s): Akiko Kogo, Tetsu Akiyama, Takao Senda
  • Organizer: 41st Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: Tokushima
  • Year and Date: 2008-05-29
• [Presentation] The role of Dlgh1 (Discs Large Homolog-1) in organogenesis (2008)
  • Author(s): Akiko Kogo
  • Organizer: 41st Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: (Tokushima)
  • Year and Date: 2008-05-29
• [Presentation] 胸部器官の発生におけるDlgh1の機能 (2008)
  • Author(s): 向後晶子、秋山徹、千田隆夫
  • Organizer: 日本解剖学会第113回全国学術集会
  • Place of Presentation: 大分
  • Year and Date: 2008-03-28
• [Presentation] 胸部器官の発生におけるDlgh1の機能 (2008)
  • Author(s): 向後晶子
  • Organizer: 第113回日本解剖学会全国学術集会
  • Place of Presentation: 大分
  • Year and Date: 2008-03-28
• [Presentation] Dlgh1遺伝子ノックアウトマウスにおける骨形成の異常について (2008)
  • Author(s): 千田隆夫、向後晶子、秋山徹
  • Organizer: 第40回日本解臨床分子形態学会
  • Place of Presentation: 福岡
• [Presentation] Dlgh1遺伝子ノックアウトマウスにおける骨形成の異常について (2008)
  • Author(s): 千田隆夫
  • Organizer: 第40回日本解臨床分子形態学会学術講演会
  • Place of Presentation: 福岡
• [Presentation] Dlgh1はマウス正中部の器官形成に必要である (2007)
  • Author(s): 向後晶子、石田尾武文、秋山徹、千田 隆夫
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] Dlgh1はマウス正中部の器官形成に必要である (2007)
  • Author(s): 向後晶子
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会 (BMB2007)
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] Dlgh1遺伝子ノックアウトマウスにおける心臓の発生異常 (2007)
  • Author(s): 向後晶子、千田隆夫
  • Organizer: 日本解剖学会第67回中部支部学術集会
  • Place of Presentation: 長久手
  • Year and Date: 2007-10-14
• [Presentation] Dlgh1遺伝子ノックアウトマウスにおける心臓の発生異常 (2007)
  • Author(s): 向後晶子
  • Organizer: 日本解剖学会 第67回中部支部学術集会
  • Place of Presentation: 長久手
  • Year and Date: 2007-10-14
• [Presentation] Dlgh1遺伝子ノックアウトマウスにおける心奇形の発生 (2007)
  • Author(s): 向後晶子、石田尾武文、秋山徹、千田隆夫
  • Organizer: 第78回日本動物学会
  • Place of Presentation: 弘前
  • Year and Date: 2007-09-22
• [Book] 組織細胞化学2009「免疫組織化学の原理と応用」(日本組織細胞化学会編) (2009)
  • Author(s): 千田隆夫・野村隆士・向後晶子・尾之内高慶
• [Book] 日本組織細胞化学会編 組織細胞化学2009「免疫組織化学の原理と応用」 (2009)
  • Author(s): 千田隆夫
  • Publisher: 日本組織細胞化学会
• [Remarks]
  • URL: http://www.fujita-hu.ac.jp/~hnagashi/KDB/open/100011.html
• [Remarks]
  • URL: http://www.fujita-hu.ac.jp/~hnagashi/KDB/open/100011.html