Calcium coupling between mitochondria and Endoplasmic Reticulum in brown adipocytes
| Project/Area Number |
19790171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Nagoya University of Arts and Sciences |
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Principal Investigator |
HIGURE Yoko Nagoya University of Arts and Sciences, 管理栄養学部, 助教 (30325633)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,765,638 (Direct Cost: ¥3,427,414、Indirect Cost: ¥338,224)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥685,638 (Direct Cost: ¥527,414、Indirect Cost: ¥158,224)
Fiscal Year 2007: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | 褐色脂肪細胞 / ミトコンドリア / 滑面小胞体 / カルシウム / 生理学 / 細胞・組織 |
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| Research Abstract |
In brown adipocytes, activation of β_3-adrenergic causes mitochondria depolarization that causes Ca^<2+> releases from mitochondria, which further elicit CICR from the ER under the actions of locally produced IP_3. The resultant depletion of Ca^<2+> in the ER activates store-operated Ca^<2+> entry.
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Report
(4 results)
Research Products
(9 results)
