Calcium coupling between mitochondria and Endoplasmic Reticulum in brown adipocytes

• Project/Area Number: 19790171
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: Nagoya University of Arts and Sciences
• Principal Investigator: HIGURE Yoko Nagoya University of Arts and Sciences, 管理栄養学部, 助教 (30325633)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,765,638 (Direct Cost: ¥3,427,414、Indirect Cost: ¥338,224); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥685,638 (Direct Cost: ¥527,414、Indirect Cost: ¥158,224); Fiscal Year 2007: ¥2,300,000 (Direct Cost: ¥2,300,000)
• Keywords: 褐色脂肪細胞 / ミトコンドリア / 滑面小胞体 / カルシウム / 生理学 / 細胞・組織

Research Abstract

In brown adipocytes, activation of β_3-adrenergic causes mitochondria depolarization that causes Ca^<2+> releases from mitochondria, which further elicit CICR from the ER under the actions of locally produced IP_3. The resultant depletion of Ca^<2+> in the ER activates store-operated Ca^<2+> entry.

Research Products

• [Presentation] 胆汁酸吸着 resin による高脂肪食肥満の防止機構における褐色脂肪細胞の交換神経応答の役割に関する研究 (2009)
  • Author(s): 安藤祐、早戸亮太郎、日暮陽子、久場雅子、久場健司
  • Organizer: 第56回中部日本生理学会
  • Place of Presentation: 石川
  • Year and Date: 2009-12-05
• [Presentation] Ca^<2+> entry activated by β-adrenergic mitochondrial uncoupling in brown adipocytes (2009)
  • Author(s): R.Hayato, Y.Higure, M.Kuba, H.Nagai, K.Kuba
  • Organizer: Society for Neuroscience 2009
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-17
• [Presentation] Interaction of alpha- and be-ta-actions on intracellular calcium dynamics of mouse browm adipocytes (2009)
  • Author(s): Ryotaro Hayato, Yoko Higure, Masako Kuba, Kenji Kuba
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-29
• [Presentation] Bile acid enhances sympathetic signaling processes in brown adipocytes and prevents obesity formation under high-fat diet (2009)
  • Author(s): Hiroki Nagai, Ryotaro Hayato, Masako Kuba, Yoko Higure, Kenji Kuba
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都
  • Year and Date: 2009-07-29
• [Presentation] Ca^<2+> entry activated by ・-adrenergic mitochondrial uncoupling in brown adipocytes (2009)
  • Author(s): R. Hayato, Y. Higure, M. Kuba, H. Nagai, K. Kuba
  • Organizer: Society for Neuroscience 2009
  • Place of Presentation: Chicago
• [Presentation] Interaction of alpha- and be-ta-actions on intracellular calcium dynamics of mouse browm adipocytes (2009)
  • Author(s): Ryotaro Hayato, Yoko Higure, Masako Kuba, Kenji Kuba
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] Bile acid enhances sympathetic signaling processes in brown adipocytes and prevents obesity formation under high-fat diet (2009)
  • Author(s): Hiroki Nagai, Ryotaro Hayato, Masako Kuba, Yoko Higure, Kenji Kuba
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] 胆汁酸吸着resinによる高脂肪食肥満の防止機構における褐色脂肪細胞の交換神経応答の役割に関する研究 (2009)
  • Author(s): 安藤祐、早戸亮太郎、日暮陽子、久場雅子、久場健司
  • Organizer: 第56回中部日本生理学
  • Place of Presentation: 石川
• [Presentation] Effect of high fat diet and cholic acids on adrenergic Ca^<2+> signaling and thermogenesis in brown adipocytes (2008)
  • Author(s): Hayato Ryotaro, Higure Yoko, Kuba Masako, Kuba Kenji
  • Organizer: The Proceedings of the 85th Annual Meeting (The physiological society of Japan)
  • Place of Presentation: ToKyo