ANALYSIS OF REGULATORY MECHANISMS FOR PLASMA MEMBRANE EXPRESSION OF 5-HT_<2A> RECEPTOR BY INSULIN
| Project/Area Number |
19790175
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Yamagata University |
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Principal Investigator |
OHKURA Masamichi Yamagata University, 医学部, 講師 (70369172)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | インスリン / セロトニン / セロトニン_<2A>受容体 / 細胞膜発現 / インターナリゼーション / ARF1 / セロトニン2A受容体 |
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| Research Abstract |
本研究ではインスリンによる細胞膜5-HT_<2A>受容体の発現制御機構を解明する目的でこの受容体と複合体を形成する蛋白質を探索した結果、低分子量G蛋白質であるARF1を見出した。さらにARF1の機能を解析した結果、ARF1がGDP結合型(不活性化型)からGTP結合型(活性型)に変換されると5-HT_<2A>受容体の細胞内陥入(インターナリゼーション)を起こすことを明らかにした。
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Rho-kinase, but not protein kinase C, is involved in generation of the spontaneous tone in the resting phase of the isolated pig iris sphincter muscle2009
Author(s)
Okano, M., Uchikawa, Y., Tanaka, N., Mutoh, J., Ohkura, M., Hisa, H., and Yamamoto, R.
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Journal Title
Current Eye Research 34
Pages: 177-183
Related Report
Peer Reviewed
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[Journal Article] Both 5-hydroxytryptamine 5-HT_<2A> and 5-HT_<1B> receptors are involved in the vasoconstrictor response to 5-HT in the human isolated internal thoracic artery2008
Author(s)
Tanaka, N., Nakamura, E., Ohkura, M., Kuwabara, M., Yamashita, A., Onitsuka, T., Asada, Y., Hisa, H., and Yamamoto, R.
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Journal Title
Clinical and Experimental Pharmacology and Physiology 35
Pages: 836-840
Related Report
Peer Reviewed
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