Regulation of the function of blood?brain barrier by adipocytokine in obesity

• Project/Area Number: 19790199
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Fukuoka University
• Principal Investigator: YAMAUCHI Atsushi Fukuoka University, 薬学部, 准教授 (90341453)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,620,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 肥満 / 血液脳関門 / アディポサイトカイン / 炎症性サイトカイン

Research Abstract

近年肥満病態で注目されている血中アディポサイトカインの血液脳関門(BBB)機能に及ぼす影響は不明である。本研究では、アディポサイトカインによるBBB機能制御機構を追求することを目的とし、BBB構成細胞のペリサイトに着目して検討した。アディポネクチンのBBB機能に対する作用はなかったが、攻撃因子として一酸化窒素、オンコスタチンM、防御因子としてTGF-βを抽出することができた。またBBBの病変化の過程にはペリサイトの機能低下が関与していることが判った。

Research Products

• [Journal Article] Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway (2009)
  • Author(s): Takata F, Dohgu S, Nishioku T, Takahashi H, Harada E, Makino I, Nakashima M, Yamauchi A, Kataoka Y.
  • Journal Title: Neurosci Lett 449(1) Pages: 71-5
  • Peer Reviewed
• [Journal Article] Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood-Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice (2009)
  • Author(s): Nishioku T, et.al.
  • Journal Title: Cell Mol Neurobiol. (in press)
  • Peer Reviewed
• [Journal Article] Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway (2009)
  • Author(s): Takata F, et.al.
  • Journal Title: Neurosci Lett. 449 Pages: 71-75
  • Peer Reviewed
• [Journal Article] Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells. (2008)
  • Author(s): Takata F, Sumi N, Nishioku T, Harada E, Wakigawa T, Shuto H, Yamauchi A, Kataoka Y.
  • Journal Title: Neurosci Lett. 441(2) Pages: 163-164
  • Peer Reviewed
• [Journal Article] Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells (2008)
  • Author(s): Takata F, et.al.
  • Journal Title: Neurosci Lett. 441 Pages: 163-166
  • Peer Reviewed
• [Journal Article] Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia- reoxygenation damage in vitro. (2007)
  • Author(s): Dohgu S, Nishioku T, Sumi N, Takata F, Nakagawa S, Naito M, Tsuruo T, Yamauchi A, Shuto H, Kataoka Y.
  • Journal Title: Cell Mol Neurobiol. 27(7) Pages: 889-899
  • Peer Reviewed
• [Journal Article] An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function. (2007)
  • Author(s): Yamauchi A, Dohgu S, Nishioku T, Shuto H, Naito M, Tsuruo T, Sawada Y, Kataoka Y.
  • Journal Title: Cell Mol Neurobiol. 27(3) Pages: 263-270
  • Peer Reviewed
• [Journal Article] Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier. (2007)
  • Author(s): Takata F, Dohgu S, Yamauchi A, Sumi N, Nakagawa S, Naito M, Tsuruo T, Shuto H, Kataoka Y.
  • Journal Title: Cell Mol Neurobiol. 27(3) Pages: 317-328
  • Peer Reviewed
• [Journal Article] An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function. (2007)
  • Author(s): Yamauchi A, et. al.
  • Journal Title: Cell Mol NeurobioL 27 Pages: 263-270
  • Peer Reviewed
• [Journal Article] Inhibition of transforming growth factorbeta production in brain pericytes contributes to cyclosporin Ainduced dysfunction of the blood-brain barrier (2007)
  • Author(s): Takata F, et. al.
  • Journal Title: Cell Mol NeurobioL 27 Pages: 317-328
  • Peer Reviewed
• [Journal Article] Detachment of Brain Pericytes from the Basal Lamina is involved in Disruption of the Blood-Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice.
  • Author(s): Nishioku T, Dohgu S, Takata F, Eto T, Ishikawa N, Kodama KB, Nakagawa S, Yamauchi A, Kataoka Y.
  • Journal Title: Cell Mol Neurobiol (in press)
  • Peer Reviewed