Mechanisms of vascular dysfunction induced by the interaction of vasoactive molecules.

• Project/Area Number: 19790200
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: FUJITA Yoshiko National Cardiovascular Center Research Institute, 脈管生理部, 室員 (30416218)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 循環 / 動脈硬化 / LOX-1 / 虚血性心疾患 / 酸化LDL

Research Abstract

本研究の目的は、血管病変を引き起こす病態下で特徴的に内皮細胞に働いてその機能変化を導き、ひいては病態全体に影響を与える分子について、その意義を明らかにすることである。血管病変を引き起こす分子として注目されている酸化LDLの受容体であるLOX-1とC-reactive protein(CRP)について研究を行った。その結果、LOX-1にCRP が結合し、血管反応に関与していることが明らかとなった。

Research Products

• [Journal Article] Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects. (2009)
  • Author(s): Fujita Y, Kakino A, Nishimichi N, Yamaguchi S, Sato Y, Machida S, Cominacini L, Delneste Y, Matsuda H, Sawamura T
  • Journal Title: Clinical Chemistry 55 Pages: 285-294
  • Peer Reviewed
• [Journal Article] Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects. (2009)
  • Author(s): Fujita Y, Kakino A, Nishimichi N, Yamaguchi S, Sato Y, Machida S, Cominacini L, Delneste Y, Matsuda H, Sawamura T.
  • Journal Title: Clinical Chemistry 55 Pages: 285-294
  • Peer Reviewed
• [Journal Article] LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice. (2008)
  • Author(s): Hu, C., Chen, J., Dandapat, A., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Li, D., Hermonat, P. L., Sawamura, T., Mehta, J. L.
  • Journal Title: Journal of Molecular Cellular Cardiology 44 Pages: 76-83
  • Peer Reviewed
• [Journal Article] LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice (2008)
  • Author(s): Hu, C.
  • Journal Title: J Mol Cell Cazdiol 44(1) Pages: 76-83
  • Peer Reviewed
• [Journal Article] Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration. (2007)
  • Author(s): Izawa, Y., Yoshizumi, M., Ishizawa, K., Fujita, Y., Kondo, S., Kagami, S., Kawazoe, K., Tsuchiya, K., Tomita, S., Tamaki, T.
  • Journal Title: Hypertension Research 30 Pages: 1107-1117
  • NAID: 10021260102
  • Peer Reviewed
• [Journal Article] LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion. (2007)
  • Author(s): Hu, C., Dandapat, A., Chen, J., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Sawamura, T., Mehta, J. L.
  • Journal Title: Cardiovasc Research 76 Pages: 292-302
  • Peer Reviewed
• [Journal Article] LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion. (2007)
  • Author(s): Hu, C.
  • Journal Title: Cardiovasc Res 76(2) Pages: 292-302
  • Peer Reviewed
• [Journal Article] Big mitogen-activated protein kinase1 (BMK1)/ERK5is involved in platlet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration (2007)
  • Author(s): Izawa, Y.
  • Journal Title: Hypertension Res 30(11) Pages: 1107-1117
  • Peer Reviewed
• [Presentation] LOX-1はC反応蛋白を結合し、そ の血管に対する反応を媒介する (2009)
  • Author(s): 藤田佳子
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 神奈川 パシフィコ横浜
  • Year and Date: 2009-03-17
• [Presentation] LOX-1はC反応蛋白を結合し、その血管に対する反応を媒介する (2009)
  • Author(s): 藤田佳子、垣野明美、西道教尚、山口三郎、佐藤優子、松田治男、沢村達也
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 神奈川(パシフィコ横浜)
  • Year and Date: 2009-03-17
• [Presentation] C-reactive protein(CRP)は酸化LDL受容体LOX-1と協調して補体活性化を引き起こす (2008)
  • Author(s): 藤田佳子
  • Organizer: 第18回日本循環薬理学会
  • Place of Presentation: 千葉 京成ホテルミラマーレ
  • Year and Date: 2008-11-21
• [Presentation] C-reactive protein (CRP)は酸化LDL受容体LOX-1と協調して補体活性化を引き起こす (2008)
  • Author(s): 藤田佳子、垣野明美、山口三郎、沢村達也
  • Organizer: 第18回日本循環薬理学会
  • Place of Presentation: 千葉(京成ホテルミラマーレ)
  • Year and Date: 2008-11-21
• [Presentation] 血栓形成過程におけるLOX-1の意義 (2008)
  • Author(s): 乙井 一典
  • Organizer: 第81回日本本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] 動脈硬化初期病変としての血管内脂肪沈着におけるLOX-1の意-SHR・SPラットを用いた検討- (2008)
  • Author(s): 井上 信孝
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17