| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Research Abstract |
When mouse preadipocyte 3T3-L1 cells are differentiated into adipocytes, the alternative splicing (AS) of insulin receptor (IR) is altered from exon-skipped isoform (IR-A) to exon-included type (IR-B). During the differentiation, CUGBP1, as known an alternative splicing regulator, redistributes from nucleus to cytoplasm. Our results suggest that the redistribution of CUGBP1 is not the primary cause of alternation of AS of IR.
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