Control of alternative splicing of insulin receptor by glucocorticoid hormone
| Project/Area Number |
19790218
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Jichi Medical University |
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Principal Investigator |
坂下 英司 Jichi Medical University, 医学部, 講師 (00337320)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 選択的スプライシング / ホルモン / RNA結合タンパク質 |
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| Research Abstract |
When mouse preadipocyte 3T3-L1 cells are differentiated into adipocytes, the alternative splicing (AS) of insulin receptor (IR) is altered from exon-skipped isoform (IR-A) to exon-included type (IR-B). During the differentiation, CUGBP1, as known an alternative splicing regulator, redistributes from nucleus to cytoplasm. Our results suggest that the redistribution of CUGBP1 is not the primary cause of alternation of AS of IR.
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Report
(4 results)
Research Products
(4 results)
