Characterization of the mechanism of biosynthesis for vitamine K dependent proteins and functional study of Vitamin K metabolic enzyme.
| Project/Area Number |
19790224
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yamagata University |
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Principal Investigator |
IWATA Hiroki Yamagata University, 医学部, 助教 (70361251)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,710,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | プロテインZ / ビタミンK / 生合成 / 発現調節 / ホルモン / 遺伝子多型 / タンパク質化学 / 酵素反応 / 血液凝固因子 / 翻訳後修飾 |
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| Research Abstract |
We characterized the 5'-flanking region of PZ gene and identified cis-acting sequences and trans-acting factors responsible for the expression of human PZ gene using HepG2. HNF-4α plays a crucial role in PZ gene expression, and that Sp1 acts as an enhancer. The levels of PZ and ZPI in plasma increased during normal pregnancy. It was suggested that the expression of PZ gene was regulated by hormones. And it was confirmed that the expression of PZ gene was enhanced by progesterone.
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Report
(4 results)
Research Products
(26 results)
