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Mechanism of tissue-specific distribution of mitochondrial SOD1

Research Project

Project/Area Number 19790231
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionOsaka University

Principal Investigator

MATSUMOTO Ayako  Osaka University, 微生物病研究所, 寄附研究部門助教 (60444519)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywords抗酸化酵素 / 活性酸素 / スーパーオキシドジスムターゼ / 筋萎縮性側索硬化症 / ミトコンドリア / 細胞質
Research Abstract

家族性筋萎縮性側索硬化症(FALS)において、ミトコンドリア内のS-ニトロシル化をうけたタンパク質量の減少が報告され、ミトコンドリア内にも局在するCu,Zn-superoxide dismutase (SOD1)のCuが脱ニトロシル化を促進しているのではないかと推測されたが、根本的な点で矛盾があったので再検討した。生体内でのSOD1による脱ニトロシル化活性は期待できるものではなく、野生型とFALS変異型SOD1において、脱ニトロシル化活性の値に有意差は認められなかったことより、FALSとSOD1の脱ニトロシル化活性との関連は見出せなかった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results) Remarks (2 results)

  • [Journal Article] Putative denitrosylase activity of Cu, Zn-superoxide dismutase.2007

    • Author(s)
      Ayako Okado-Matsumoto, Irwin Fridovich
    • Journal Title

      Free Radical Biology and Medicine 43(5)

      Pages: 830-836

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Putative denitrosylase activity of Cu, Zn-superoxide dismutase.2007

    • Author(s)
      Ayako Okado-Matumoto
    • Journal Title

      Free Radical Biology and Medicine 43 (5)

      Pages: 830-836

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] スーパーオキシドディスムターゼにおけるS-ニトロソチオール代謝活性2008

    • Author(s)
      松本紋子
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Cystamine effects as a treatment for amyotrophic lateral sclerosis.2008

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      SFRBM 15^<th> Annual Meeting
    • Place of Presentation
      Indianapolis, USA
    • Year and Date
      2008-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Cystamine effects as a treatment for amyotrophic lateral sclerosis2008

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      SFRBM 15^<th> Annual Meeting
    • Place of Presentation
      インディアナポリス、アメリカ合衆国
    • Year and Date
      2008-11-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] スーパーオキシドディスムターゼにおけるS-ニトロソチオール代謝活性2008

    • Author(s)
      松本紋子
    • Organizer
      第61回日本酸化ストレス学会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Putative Denitrosylase Activity of Cu, Zn-Superoxide Dismutase.2007

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      BMB 2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2008 Final Research Report
  • [Presentation] Putative Denitrosylase Activity of Cu, Zn-Superoxide Dismutase.2007

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Putative Denitrosylase Activity of Cu, Zn-Superoxide Dismutase.2007

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      SFRBM 14^<th> Annual Meeting
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2007-11-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Putative Denitrosylase Activity of Cu, Zn-Superoxide Dismutase.2007

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      SFRBM 14th Annual Meeting
    • Place of Presentation
      ワシントンDC、アメリカ合衆国
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Modification of Cysteine 111 in Human Cu, Zn-superoxide Dismutase.2007

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      The 27^<th> International Symposium of Cancer in Sapporo.
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Modification of Cysteine 111 in Human Cu, Zn-Superoxide Dismutase2007

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      The 27th International Symposium on Cancer in Sapporo
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Modification of Cysteine 111 in Human Cu, Zn-superoxide Dismutase.2007

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      Experimental Biology 2007 Annual Meeting
    • Place of Presentation
      Washington DC, USA.
    • Year and Date
      2007-04-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Modification of Cysteine 111 in Human Cu, Zn-Superoxide Dismutase.2007

    • Author(s)
      Ayako Okado-Matsumoto
    • Organizer
      Experimental Biology 2007 Annual Meeting
    • Place of Presentation
      ワシントンDC、アメリカ合衆国
    • Year and Date
      2007-04-30
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jP/lab/disglyco/Site/Home.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/lab/disglyco/Site/Home.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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