Mechanism of tissue-specific distribution of mitochondrial SOD1

• Project/Area Number: 19790231
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Osaka University
• Principal Investigator: MATSUMOTO Ayako Osaka University, 微生物病研究所, 寄附研究部門助教 (60444519)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: 抗酸化酵素 / 活性酸素 / スーパーオキシドジスムターゼ / 筋萎縮性側索硬化症 / ミトコンドリア / 細胞質

Research Abstract

家族性筋萎縮性側索硬化症(FALS)において、ミトコンドリア内のS-ニトロシル化をうけたタンパク質量の減少が報告され、ミトコンドリア内にも局在するCu,Zn-superoxide dismutase (SOD1)のCuが脱ニトロシル化を促進しているのではないかと推測されたが、根本的な点で矛盾があったので再検討した。生体内でのSOD1による脱ニトロシル化活性は期待できるものではなく、野生型とFALS変異型SOD1において、脱ニトロシル化活性の値に有意差は認められなかったことより、FALSとSOD1の脱ニトロシル化活性との関連は見出せなかった。

Research Products

• [Journal Article] Putative denitrosylase activity of Cu, Zn-superoxide dismutase. (2007)
  • Author(s): Ayako Okado-Matsumoto, Irwin Fridovich
  • Journal Title: Free Radical Biology and Medicine 43(5) Pages: 830-836
  • Peer Reviewed
• [Journal Article] Putative denitrosylase activity of Cu, Zn-superoxide dismutase. (2007)
  • Author(s): Ayako Okado-Matumoto
  • Journal Title: Free Radical Biology and Medicine 43 (5) Pages: 830-836
  • Peer Reviewed
• [Presentation] スーパーオキシドディスムターゼにおけるS-ニトロソチオール代謝活性 (2008)
  • Author(s): 松本紋子
  • Organizer: BMB2008
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Cystamine effects as a treatment for amyotrophic lateral sclerosis. (2008)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: SFRBM 15^<th> Annual Meeting
  • Place of Presentation: Indianapolis, USA
  • Year and Date: 2008-11-21
• [Presentation] Cystamine effects as a treatment for amyotrophic lateral sclerosis (2008)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: SFRBM 15^<th> Annual Meeting
  • Place of Presentation: インディアナポリス、アメリカ合衆国
  • Year and Date: 2008-11-21
• [Presentation] スーパーオキシドディスムターゼにおけるS-ニトロソチオール代謝活性 (2008)
  • Author(s): 松本紋子
  • Organizer: 第61回日本酸化ストレス学会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-20
• [Presentation] Putative Denitrosylase Activity of Cu, Zn-Superoxide Dismutase. (2007)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: BMB 2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] Putative Denitrosylase Activity of Cu, Zn-Superoxide Dismutase. (2007)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: BMB2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] Putative Denitrosylase Activity of Cu, Zn-Superoxide Dismutase. (2007)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: SFRBM 14^<th> Annual Meeting
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2007-11-15
• [Presentation] Putative Denitrosylase Activity of Cu, Zn-Superoxide Dismutase. (2007)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: SFRBM 14th Annual Meeting
  • Place of Presentation: ワシントンDC、アメリカ合衆国
  • Year and Date: 2007-11-15
• [Presentation] Modification of Cysteine 111 in Human Cu, Zn-superoxide Dismutase. (2007)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: The 27^<th> International Symposium of Cancer in Sapporo.
  • Place of Presentation: 札幌
  • Year and Date: 2007-07-12
• [Presentation] Modification of Cysteine 111 in Human Cu, Zn-Superoxide Dismutase (2007)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: The 27th International Symposium on Cancer in Sapporo
  • Place of Presentation: 札幌
  • Year and Date: 2007-07-12
• [Presentation] Modification of Cysteine 111 in Human Cu, Zn-superoxide Dismutase. (2007)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: Experimental Biology 2007 Annual Meeting
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2007-04-30
• [Presentation] Modification of Cysteine 111 in Human Cu, Zn-Superoxide Dismutase. (2007)
  • Author(s): Ayako Okado-Matsumoto
  • Organizer: Experimental Biology 2007 Annual Meeting
  • Place of Presentation: ワシントンDC、アメリカ合衆国
  • Year and Date: 2007-04-30
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jP/lab/disglyco/Site/Home.html
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jp/lab/disglyco/Site/Home.html